A5005776897- Pain Mechanisms and Treatments
- Neuropeptides and Animal Physiology
- Stress Responses and Cortisol
- Receptor Mechanisms and Signaling
- Pain Management and Placebo Effect
- Neuroendocrine regulation and behavior
- Veterinary Pharmacology and Anesthesia
- Pediatric Pain Management Techniques
- Pharmacological Effects of Natural Compounds
- Cancer, Stress, Anesthesia, and Immune Response
- Musculoskeletal pain and rehabilitation
- Neurotransmitter Receptor Influence on Behavior
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Olfactory and Sensory Function Studies
- Animal testing and alternatives
- Ion channel regulation and function
- Pharmacological Receptor Mechanisms and Effects
- Human-Animal Interaction Studies
- Neuroscience and Neuropharmacology Research
- Sex and Gender in Healthcare
- Pain Management and Opioid Use
- Anesthesia and Pain Management
- Hereditary Neurological Disorders
- Diet and metabolism studies
- Genetic Mapping and Diversity in Plants and Animals
McGill University
2016-2025
Edwards (United Kingdom)
2009-2024
McGill University Health Centre
2009-2023
Creative Commons
2020
University of North Carolina at Chapel Hill
2015
University of Toronto
2015
National Center for Biotechnology Information
2015
National Institutes of Health
2015
Community Link
2015
Centre for Addiction and Mental Health
2014
In September 2006, members of the Sex, Gender and Pain Special Interest Group International Association for Study met to discuss following: (1) what is known about sex gender differences in pain analgesia; (2) are “best practice” guidelines research with respect gender; (3) crucial questions address near future? The resulting consensus presented herein includes input from basic science, clinical psychosocial researchers, as well recognized experts sexual differentiation reproductive...
Empathy is thought to be unique higher primates, possibly humans alone. We report the modulation of pain sensitivity in mice produced solely by exposure their cagemates, but not strangers, pain. Mice tested dyads and given an identical noxious stimulus displayed increased behaviors with statistically greater co-occurrence, effects dependent on visual observation. When familiar were stimuli different intensities, behavior was influenced neighbor's status bidirectionally. Finally, observation...
We recently demonstrated the utility of quantifying spontaneous pain in mice via blinded coding facial expressions. As majority preclinical research is fact performed laboratory rat, we attempted to modify scale for use this species. present herein Rat Grimace Scale, and show its reliability, accuracy, ability quantify time course intraplantar complete Freund's adjuvant, intraarticular kaolin-carrageenan, laparotomy (post-operative pain) assays. The scale's demonstrate dose-dependent...
It is generally acknowledged that humans display highly variable sensitivity to pain, including responses identical injuries or pathologies. The possible contribution of genetic factors has, however, been largely overlooked. An emerging rodent literature documents the importance genotype in mediating basal nociceptive sensitivity, establishing a predisposition neuropathic pain following neural injury, and determining pharmacological agents endogenous antinociception. One clear finding from...
Sex specificity of neural mechanisms modulating nociceptive information has been demonstrated in rodents, and these qualitative sex differences appear to be relevant analgesia from κ-opioid receptor agonists, a drug class reported clinically effective only women. Via quantitative trait locus mapping followed by candidate gene strategy using both mutant mice pharmacological tools, we now demonstrate that the melanocortin-1 ( Mc1r ) mediates female only. This finding suggested individuals with...
We present a detailed framework for understanding the numerous and complicated interactions among psychological social determinants of pain through examination process communication. The focus is on an improved immediate dyadic transactions during painful events in context broader phenomena. Fine-grain consideration leads to appreciation sociobehavioral affecting both suffering persons as well caregivers. Our considers knowledge from variety perspectives, including clinical health...
The innate immune system is increasingly appreciated to play an important role in the mediation of chronic pain, and one molecule implicated this process Toll-like receptor 4 (TLR4). Here, using pharmacological genetic manipulations, we found that activating TLR4 spinal cord, with agonist lipopolysaccharide (LPS), causes robust mechanical allodynia but only male mice. Spinal LPS had no pain-producing effect female also has a sex-specific inflammatory (complete Freund's adjuvant) neuropathic...
Neuropathic pain resulting from damage to or dysfunction of peripheral nerves is not well understood and difficult treat. Although CNS hyperexcitability a critical component, recent findings challenge the neuron-centric view neuropathic etiology pathology. Indeed, glial cells were shown play an active role in initiation maintenance hypersensitivity. However, origins these triggers that induce their activation have yet be elucidated. Here we show that, after nerve injury induced by partial...