A5047259166- Pain Mechanisms and Treatments
- Neuroscience and Neuropharmacology Research
- Neuropeptides and Animal Physiology
- Healthcare and Venom Research
- Sphingolipid Metabolism and Signaling
- Neuroinflammation and Neurodegeneration Mechanisms
- Ion channel regulation and function
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Cancer, Stress, Anesthesia, and Immune Response
- Herpesvirus Infections and Treatments
- Stress Responses and Cortisol
- Pain Management and Opioid Use
- Neuroendocrine regulation and behavior
- Exercise and Physiological Responses
- Veterinary Equine Medical Research
- Hereditary Neurological Disorders
- Inflammasome and immune disorders
- Melanoma and MAPK Pathways
- Metabolism and Genetic Disorders
- Multiple Sclerosis Research Studies
- Olfactory and Sensory Function Studies
- Regulation of Appetite and Obesity
- Plant-based Medicinal Research
- Vector-borne infectious diseases
- melanin and skin pigmentation
Karolinska Institutet
2012-2022
Rush University Medical Center
2017
University of Edinburgh
2003-2012
Western General Hospital
2010
Medical Research Council
2010
Trinity College Dublin
2004
Texas Research Institute
1986
During peripheral immune activation caused by an infection or inflammatory condition, the innate response signals to brain and causes up-regulation of central nervous system (CNS) cytokine production. Central actions proinflammatory cytokines, in particular IL-1β, are pivotal for induction fever fatigue. In present study, influence chronic joint disease rheumatoid arthritis (RA) on CNS inflammation was investigated. Intrathecal interleukin (IL)-1β concentrations were markedly elevated RA...
Parenterally administered lipopolysaccharide (LPS) increases the concentration of pro-inflammatory cytokine interleukin-1beta (IL-1beta) in rat hippocampus and evidence suggests that this effect plays a significant role inhibiting long-term potentiation (LTP). The anti-inflammatory IL-10, antagonizes certain effects IL-1beta, so if LPS are mediated through an increase it might be predicted IL-10 would also abrogate LPS. Here, we report reversed inhibitory on LTP data couple with LPS-induced...
Reactivation of latent varicella zoster virus (VZV) within sensory trigeminal and dorsal root ganglia (DRG) neurons produces shingles (zoster), often accompanied by a chronic neuropathic pain state, post-herpetic neuralgia (PHN). PHN persists despite latency the human is unresponsive to current analgesic or antiviral agents. To study basis zoster-induced pain, we have utilised recently developed model VZV infection in rodents. Immunohistochemical analysis DRG following showed presence viral...
Abstract Burrowing, an ethologically relevant rodent behaviour, has been proposed as a novel outcome measure to assess the global impact of pain in rats. In prospective multicentre study using male rats (Wistar, Sprague-Dawley), replication suppressed burrowing behaviour complete Freund adjuvant (CFA)-induced model inflammatory (unilateral, 1 mg/mL 100 µL) was evaluated 11 studies across 8 centres. Following standard protocol, data from participating centres were collected centrally and...
SummaryPredictions that conduction velocities are sensitive to the distance between nodes of Ranvier in myelinated axons have implications for nervous system function during growth and repair [1–3]. Internodal lengths defined by Schwann cells hindlimb nerves, example, can undergo a 4-fold increase mouse development, regenerated nerves internodes uniformly short [4, 5]. Nevertheless, influence internodal length on speed has limited experimental support. Here, we examined this problem mice...
Laminitis is a common debilitating disease in horses that involves painful disruption of the lamellar dermo-epidermal junction within hoof.This condition often refractory to conventional anti-inflammatory analgesia and results unremitting pain, which severe cases requires euthanasia.The mechanisms underlying pain laminitis were investigated using quantification behavioural indicators conjunction with histological studies peripheral nerves innervating hoof.Laminitic displayed consistently...
To determine the ability of drugs that activate inhibitory G protein-coupled receptors (GPCRs) expressed in peripheral voltage-gated sodium channel 1.8 (NaV 1.8)-positive sensory neurons to control osteoarthritis (OA)-associated pain.We used designer exclusively activated by a drug (DREADD) technology, which employs engineered GPCRs or inhibit upon binding synthetic ligand clozapine N-oxide (CNO). NaV 1.8-Pdi C57BL/6 mice were generated express DREADD receptor Pdi 1.8-expressing neurons....
Inflammatory and neuropathic-like components underlie rheumatoid arthritis (RA)-associated pain, lysophosphatidic acid (LPA) is linked to both joint inflammation in RA patients neuropathic pain. Thus, we investigated a role for LPA signalling using the collagen antibody-induced (CAIA) model. Pain-like behavior during inflammatory phase late, of CAIA was reversed by neutralizing antibody generated against an LPA1/3 receptor inhibitor, but not affected. Autotaxin, synthesizing enzyme...
Response to painful stimuli is susceptible genetic variation. Numerous loci have been identified which contribute this variation, one of which, MC1R, better known as a gene involved in mammalian hair colour. MC1R G protein-coupled receptor expressed melanocytes and elsewhere mice lacking yellow hair, whilst humans with variant protein red hair. Previous work has found differences acute pain perception, response analgesia mutations or variants MC1R.We tested responses noxious non-noxious...
Sensitization to inflammatory pain is a pathological form of neuronal plasticity that poorly understood and treated. Here we examine the role SH3 domain postsynaptic density 95 (PSD95) by using mice carry single amino‐acid substitution in polyproline‐binding site. Testing multiple forms found sensitization inflammation was specifically attenuated. The response required recruitment phosphatidylinositol‐3‐kinase‐C2α SH3‐binding site PSD95. In wild‐type mice, wortmannin or peptide competition...
Abstract Astrocyte activation is an important feature in many disorders of the central nervous system, including chronic pain conditions. Activation astrocytes characterized by a change morphology, hypertrophy and increased size processes, proliferation, production proinflammatory mediators. The xanthine derivatives pentoxifylline propentofylline are commonly used experimentally as glial inhibitors. These compounds generally believed to attenuate activity raising cyclic AMP (cAMP) levels...