A5033726496- Neuroinflammation and Neurodegeneration Mechanisms
- Neurogenesis and neuroplasticity mechanisms
- Stress Responses and Cortisol
- Tryptophan and brain disorders
- Neuroscience and Neuropharmacology Research
- Parkinson's Disease Mechanisms and Treatments
- Nuclear Receptors and Signaling
- Immune Response and Inflammation
- Diet and metabolism studies
- Gut microbiota and health
- Nerve injury and regeneration
- Memory and Neural Mechanisms
- Anesthesia and Neurotoxicity Research
- Neuroendocrine regulation and behavior
- Innovations in Medical Education
- Alzheimer's disease research and treatments
- Anatomy and Medical Technology
- Cancer Genomics and Diagnostics
- MicroRNA in disease regulation
- Genetics and Neurodevelopmental Disorders
- Apelin-related biomedical research
- Magnesium in Health and Disease
- Cancer-related molecular mechanisms research
- NF-κB Signaling Pathways
- Analytical Chemistry and Sensors
University College Cork
2015-2024
APC Microbiome Institute
2015-2024
Cork University Hospital
2021
London North West Healthcare NHS Trust
2017-2018
Teagasc - The Irish Agriculture and Food Development Authority
2015
Trinity College Dublin
2001-2007
National University of Ireland
2005
Ollscoil na Gaillimhe – University of Galway
1998-2002
Alzheimer's disease is a complex neurodegenerative disorder leading to decline in cognitive function and mental health. Recent research has positioned the gut microbiota as an important susceptibility factor by showing specific alterations microbiome composition of patients rodent models. However, it unknown whether are causal manifestation symptoms. To understand involvement patient host physiology behaviour, we transplanted faecal from age-matched healthy controls into microbiota-depleted...
Middle age has historically been an understudied period of life compared to older age, when cognitive and brain health decline are most pronounced, but the scope for intervention may be limited. However, recent research suggests that middle could mark a shift in aging. We review emerging evidence on multiple levels analysis indicating midlife is defined by unique central peripheral processes shape future trajectories health. Informed developments aging lifespan studies humans animal models,...
Abstract It is well established that inflammatory changes contribute to brain ageing, and an increased concentration of proinflammatory cytokine, interleukin‐1β (IL‐1β), has been reported in the aged associated with a deficit long‐term potentiation (LTP) rat hippocampus. The precise age at which are initiated unclear. In this study, we investigate parallel markers inflammation LTP 3‐, 9‐ 15‐month‐old rats. We report evidence hippocampal concentrations cytokines IL‐1α, IL‐18 interferon‐γ...
Deficits in cognitive function are associated with neuroinflammatory changes, typified by activation of glial cells and an alteration the pro- anti-inflammatory cytokine balance brain. Although there is evidence to suggest that microglia regulated interaction other cell types brain, mechanism(s) involved poorly understood. Here, we provide between CD200 its receptor plays a role modulating microglial under conditions chronic acute inflammation We report interleukin-4 (IL-4) central...
It is well documented that long term potentiation (LTP) impaired in the hippocampus of aged animal. Among changes contribute to this impairment an increase hippocampal concentration pro-inflammatory cytokine interleukin-1beta (IL-1beta), and increased IL-1beta-induced signaling. In study we investigated possibility these were a consequence decreased anti-inflammatory cytokine, IL-4, IL-4-stimulated We report functional IL-4 receptors are expressed on granule cells dentate gyrus receptor...
Abstract Monitoring cell and tissue oxygenation is important for the analysis of development differentiation, mitochondrial function, common (patho)physiological conditions such as ischemia, cancer, neurodegenerative disorders. A number materials sensing cellular oxygen (O 2 ) by optical means have been described in recent years, but diverse range biological models measurement tasks demands more versatile, flexible, simple O sensors. new cell‐penetrating phosphorescent nanosensor material...
Abstract Background A hallmark feature of Parkinson's disease (PD) is the build‐up α‐synuclein protein aggregates throughout brain; however also expressed in enteric neurons. Gastrointestinal (GI) symptoms and pathology are frequently reported PD, including constipation, increased intestinal permeability, glial pathology, alterations to gut microbiota composition. can propagate through neuronal systems but site origin whether it be or brain, still unknown. Physical exercise associated with...
Lifestyle factors, especially exercise, impact the manifestation and progression of psychiatric neurodegenerative disorders such as depression Alzheimer's disease, mediated by changes in hippocampal neuroplasticity. The beneficial effects exercise may be due to its promotion adult neurogenesis (AHN). Gut microbiota has also been showed altered a variety brain disorders, disturbances have resulted alterations behaviour. However, whether can counteract negative gut on function remains under...
Abstract Alzheimer's disease is a complex and progressive condition that affects essential neurological functions such as memory reasoning. In the brain, neuronal loss, synaptic dysfunction, proteinopathy, neurofibrillary tangles, neuroinflammation are hallmarks of pathophysiology. addition, recent evidence has highlighted microbes, whether commensal or pathogenic, also have ability to interact with their host regulate its immune system, therefore participating in exchanges lead peripheral...
In our ageing global population, the cognitive decline associated with dementia and neurodegenerative diseases represents a major healthcare problem. To date, there are no effective treatments for age-related impairment, thus preventative strategies urgently required. Physical exercise is gaining traction as non-pharmacological approach to promote brain health. Adult hippocampal neurogenesis (AHN), unique form of plasticity which necessary certain functions declines age enhanced in response...
Lipopolysaccharide (LPS), a component of the cell wall Gram-negative bacteria, has been shown to induce profound changes both peripherally and centrally. It recently reported that intraperitoneal injection LPS inhibited long term potentiation (LTP) in perforant path-granule synapses this effect was coupled with an increase concentration proinflammatory cytokine, interleukin-1β (IL-1β). The LPS-induced effects were abrogated by inhibition caspase-1, suggesting IL-1β may mediate LPS. Here we...
Parenterally administered lipopolysaccharide (LPS) increases the concentration of pro-inflammatory cytokine interleukin-1beta (IL-1beta) in rat hippocampus and evidence suggests that this effect plays a significant role inhibiting long-term potentiation (LTP). The anti-inflammatory IL-10, antagonizes certain effects IL-1beta, so if LPS are mediated through an increase it might be predicted IL-10 would also abrogate LPS. Here, we report reversed inhibitory on LTP data couple with LPS-induced...
Several effects of the proinflammatory cytokine, interleukin-1β (IL-1β), have been described in central nervous system, and one area brain where marked changes reported is hippocampus. Among these are an IL-1β-induced inhibition long term potentiation (LTP) perforant path-granule cell synapses attenuation glutamate release synaptosomes prepared from Evidence suggests that, at least circulating cells, anti-inflammatory IL-10, antagonizes certain IL-1. We investigated effect IL-10 on LTP...