A5077464269- Neuroinflammation and Neurodegeneration Mechanisms
- Immune Response and Inflammation
- Physical Activity and Health
- Neuroscience and Neuropharmacology Research
- Health Literacy and Information Accessibility
- Peroxisome Proliferator-Activated Receptors
- NF-κB Signaling Pathways
- Cell death mechanisms and regulation
- Neurogenesis and neuroplasticity mechanisms
- Sphingolipid Metabolism and Signaling
- Alcoholism and Thiamine Deficiency
- Vitamin C and Antioxidants Research
- Prosthetics and Rehabilitation Robotics
- School Health and Nursing Education
- Assisted Reproductive Technology and Twin Pregnancy
- Smoking Behavior and Cessation
- Chemokine receptors and signaling
- Nanocluster Synthesis and Applications
- Endoplasmic Reticulum Stress and Disease
- Motivation and Self-Concept in Sports
- Advanced Nanomaterials in Catalysis
- Obesity, Physical Activity, Diet
- Fatty Acid Research and Health
- Cardiovascular Health and Risk Factors
- Electroconvulsive Therapy Studies
Trinity College Dublin
2007-2024
St. Lawrence University
2011
Trinity College
2009
University College Dublin
2007
Several neurodegenerative disorders are associated with evidence of inflammation, one feature which is increased activation microglia, the most likely cellular source inflammatory cytokines like interleukin-1beta. It now recognized that interaction microglia other cells contributes to maintenance in a quiescent state and complementary distribution chemokine, fractalkine (CX(3)CL1) on neurons its receptor (CX(3)CR1) suggests this may play role modulating microglial activation. Here we...
Background: Parents of children with rare conditions increasingly use the Internet to source information on their child's condition. This study reports part a larger whose overall aim was identify by parents when seeking condition, specific purpose using findings aid in development website specifically designed meet parents' needs. It presents why these Internet, and support content they source, impact resources have capacity care for manage Objective: To (1) ascertain general usage...
Parenterally administered lipopolysaccharide (LPS) increases the concentration of pro-inflammatory cytokine interleukin-1beta (IL-1beta) in rat hippocampus and evidence suggests that this effect plays a significant role inhibiting long-term potentiation (LTP). The anti-inflammatory IL-10, antagonizes certain effects IL-1beta, so if LPS are mediated through an increase it might be predicted IL-10 would also abrogate LPS. Here, we report reversed inhibitory on LTP data couple with LPS-induced...
Several effects of the proinflammatory cytokine, interleukin-1β (IL-1β), have been described in central nervous system, and one area brain where marked changes reported is hippocampus. Among these are an IL-1β-induced inhibition long term potentiation (LTP) perforant path-granule cell synapses attenuation glutamate release synaptosomes prepared from Evidence suggests that, at least circulating cells, anti-inflammatory IL-10, antagonizes certain IL-1. We investigated effect IL-10 on LTP...
Abstract Evidence from several studies indicates that expression of interleukin‐1β (IL‐1β) and IL‐1 type I receptor is particularly high in hippocampus, it has recently been shown the concentration IL‐1β increased hippocampus aged rat. Here we report this increase coupled with an activity receptor‐associated kinase. The evidence presented age‐related mitogen‐activated protein kinases, Jun N‐terminal kinase (JNK) p38, was accompanied by enhanced caspase‐3 activity. Analysis colocalization...
Abstract The age‐related deficit in long‐term potentiation (LTP) the dentate gyrus is positively correlated with hippocampal concentration of pro‐inflammatory cytokine, interleukin‐1β (IL‐1β). Previous evidence also indicates that inhibition LTP induced by intracerebroventricular injection amyloid‐β 1–40 (Aβ) accompanied increased IL‐1β and IL‐1β‐stimulated signalling, specifically activation stress‐activated protein kinase, c‐jun N‐terminal kinase (JNK). We considered underlying...
Abstract Long‐term potentiation (LTP) in both area CA1 and the dentate gyrus is attenuated by stress evidence consistent with view that this a consequence of increased activation glucocorticoid receptors, hippocampus, following stress‐induced increase circulating corticosterone. It has been shown expression pro‐inflammatory cytokine, interleukin‐1β (IL‐1β), hippocampus response to stress; finding together observation IL‐1β exerts an inhibitory effect on LTP, suggests may play key role...
Abstract Lipopolysaccharide (LPS) exerts a myriad of effects in rat hippocampus; it increases the concentration proinflammatory cytokine, interleukin‐1β (IL‐1β), and signalling via IL‐1 type I receptor (IL‐1RI) resulting phosphorylation stress‐activated protein kinase, c‐jun‐N‐terminal kinase (JNK) impairment long‐term potentiation (LTP). This study was designed to establish whether activation JNK is pivotal event mediating LPS hippocampus therefore LPS‐treated rats were injected...
Among the many reported effects of irradiation in cells is activation stress-activated protein kinase, c-Jun N-terminal kinase (JNK), which has been shown to result apoptotic cell death. The trigger that leads JNK not identified, although, rat hippocampus at least, irradiation-induced apoptosis coupled with increased accumulation reactive oxygen species (ROS). Significantly, changes are abrogated by treatment rats polyunsaturated fatty acid, eicosapentaenoic acid (EPA). A close coupling...
Approximately 70% of older adults do not meet physical activity (PA) guidelines. While many interventions, are used in promoting PA, few target or include substantial behavioural change techniques. Setting PA goals is often but there less research on goal setting outcomes, like improving health, preventing age effects, flexibility, that have been associated with increased likelihood maintenance PA. To understand the concept more fully this cohort, aim study was to identify adults' outcomes -...
While the facilitators/barriers for initiation of physical activity (PA) are well documented, there is less known about these maintenance PA in older population general and not following an intervention. This study aimed to explore adults’ perspectives on maintaining PA. The used a descriptive qualitative design, with three focus groups, one Ireland two France. Participants were community-dwelling adults (≥60 years) 66% female, recruited through adult websites. Findings analyzed thematically...
Louise Doyle and colleagues present the benefits of drug treatments for people intending to overcome alcohol addiction discuss their implications nursing practice
Overview This module will give a brief overview of typical and atypical antipsychotic drugs their modes action. The pharmacological management extrapyramidal side-effects be discussed in detail. Nursing considerations when administering also outlined. conclude by summarizing the key points.
It has been lately established that inflammation plays a significant role in the pathogenesis of brain injury. Both Aβ generation inside or its uptake from systemic circulation into via blood barrier is known to cause and Released cytokines are neuro-toxic may prevent neural stem cell differentiation, proper gaseous exchange, increase risk exposure hypoxic conditions. Stem therapy seem be good way replace depleted population, although altered redox conditions as well inflammatory not permit...