A5062651402- Neurogenesis and neuroplasticity mechanisms
- Diet and metabolism studies
- Stress Responses and Cortisol
- Tryptophan and brain disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Nutritional Studies and Diet
- Alzheimer's disease research and treatments
- Nuclear Receptors and Signaling
- Nerve injury and regeneration
- Metabolomics and Mass Spectrometry Studies
- Neuroendocrine regulation and behavior
- Neuroscience and Neuropharmacology Research
- Genetics, Aging, and Longevity in Model Organisms
- MicroRNA in disease regulation
- Gut microbiota and health
- Cancer-related cognitive impairment studies
- Axon Guidance and Neuronal Signaling
- Glioma Diagnosis and Treatment
- Anesthesia and Neurotoxicity Research
- Hormonal Regulation and Hypertension
- Birth, Development, and Health
- Epigenetics and DNA Methylation
- Spinal Cord Injury Research
- Dietary Effects on Health
- Genetics and Neurodevelopmental Disorders
King's College London
2016-2025
TU Dresden
2020-2024
University Hospital Carl Gustav Carus
2020-2024
Neuroscience Institute
2016-2020
The London College
2020
King's College Hospital
2016
Universidade Federal do Rio de Janeiro
2014
Centro San Giovanni di Dio Fatebenefratelli
2014
Salk Institute for Biological Studies
2004-2013
Medical Research Council
2013
Antidepressants increase adult hippocampal neurogenesis in animal models, but the underlying molecular mechanisms are unknown. In this study, we used human progenitor cells to investigate pathways involved antidepressant-induced modulation of neurogenesis. Because our previous studies have shown that antidepressants regulate glucocorticoid receptor (GR) function, specifically tested whether GR may be effects these drugs on We found treatment (for 3-10 days) with antidepressant, sertraline,...
Stress and glucocorticoid hormones regulate hippocampal neurogenesis, but the molecular mechanisms mediating these effects are poorly understood. Here we identify receptor (GR) target gene, serum- glucocorticoid-inducible kinase 1 (SGK1), as one such mechanism. Using a human progenitor cell line, found that small molecule inhibitor for SGK1, GSK650394, counteracted cortisol-induced reduction in neurogenesis. Moreover, gene expression pathway analysis showed inhibition of neurogenic Hedgehog...
Stress and glucocorticoid hormones regulate hippocampal neurogenesis, but the molecular mechanisms underlying their effects are unknown. We, therefore, investigated signaling pathways mediating of cortisol on proliferation, neuronal differentiation, astrogliogenesis, in an immortalized human progenitor cell line. In addition, we examined activated hippocampus prenatally stressed rats, characterized by persistently elevated levels adulthood. cells, found that low concentrations (100 nM)...
Neural stem cells residing in the hippocampal neurogenic niche sustain lifelong neurogenesis adult brain. Adult (AHN) is functionally linked to mnemonic and cognitive plasticity humans rodents. In Alzheimer's disease (AD), process of generating new neurons at impeded, yet mechanisms involved are unknown. Here we identify miR-132, one most consistently downregulated microRNAs AD, as a potent regulator AHN, exerting cell-autonomous proneurogenic effects neural their progeny. Using distinct AD...
Alzheimer's disease is a complex neurodegenerative disorder leading to decline in cognitive function and mental health. Recent research has positioned the gut microbiota as an important susceptibility factor by showing specific alterations microbiome composition of patients rodent models. However, it unknown whether are causal manifestation symptoms. To understand involvement patient host physiology behaviour, we transplanted faecal from age-matched healthy controls into microbiota-depleted...
In humans, interferon-α treatment for chronic viral hepatitis is a well-recognized clinical model inflammation-induced depression, but the molecular mechanisms underlying these effects are not clear. Following peripheral administration in rodents, induces signal transducer and activator of transcription-1 (STAT1) within hippocampus disrupts hippocampal neurogenesis.We used human progenitor cell line HPC0A07/03C to evaluate 2 concentrations interferon-α, similar those observed serum during...
Abstract Daily calorie restriction (CR) and intermittent fasting (IF) enhance longevity cognition but the effects mechanisms that differentiate these two paradigms are unknown. We examined whether IF in form of every-other-day feeding enhances adult hippocampal neurogenesis (AHN) when compared to a matched 10% daily CR intake ad libitum conditions. After 3 months under IF, female C57BL6 mice exhibited improved long-term memory retention. increased number BrdU-labeled cells neuroblasts...
Chronic stress can alter the immune system, adult hippocampal neurogenesis and induce anxiety- depressive-like behaviour in rodents. However, previous studies have not discriminated between effect(s) of different types on these behavioural biological outcomes. We investigated repeated injection vs. permanent social isolation behaviour, responsivity, system functioning neurogenesis, young male mice, found that type exposure does indeed matter. Exposure to 6 weeks resulted an anxiety-like...