A5041007047- Stress Responses and Cortisol
- Tryptophan and brain disorders
- Neurogenesis and neuroplasticity mechanisms
- Neuroendocrine regulation and behavior
- Neuroinflammation and Neurodegeneration Mechanisms
- Genetics and Neurodevelopmental Disorders
- Anesthesia and Neurotoxicity Research
- Neuroscience and Neuropharmacology Research
- Mechanisms of cancer metastasis
- MicroRNA in disease regulation
- Cancer-related cognitive impairment studies
- S100 Proteins and Annexins
- Adrenal Hormones and Disorders
- Nuclear Receptors and Signaling
- Adipose Tissue and Metabolism
- Glioma Diagnosis and Treatment
- Traumatic Brain Injury and Neurovascular Disturbances
- Circadian rhythm and melatonin
- Vitamin D Research Studies
- Hormonal Regulation and Hypertension
- Diet and metabolism studies
- Traumatic Brain Injury Research
- Cancer, Stress, Anesthesia, and Immune Response
University of Oxford
2018-2023
Abbott Fund
2021
King's College London
2011-2020
Centro San Giovanni di Dio Fatebenefratelli
2014
Stress and glucocorticoid hormones regulate hippocampal neurogenesis, but the molecular mechanisms mediating these effects are poorly understood. Here we identify receptor (GR) target gene, serum- glucocorticoid-inducible kinase 1 (SGK1), as one such mechanism. Using a human progenitor cell line, found that small molecule inhibitor for SGK1, GSK650394, counteracted cortisol-induced reduction in neurogenesis. Moreover, gene expression pathway analysis showed inhibition of neurogenic Hedgehog...
Stress and glucocorticoid hormones regulate hippocampal neurogenesis, but the molecular mechanisms underlying their effects are unknown. We, therefore, investigated signaling pathways mediating of cortisol on proliferation, neuronal differentiation, astrogliogenesis, in an immortalized human progenitor cell line. In addition, we examined activated hippocampus prenatally stressed rats, characterized by persistently elevated levels adulthood. cells, found that low concentrations (100 nM)...
Chronic stress can alter the immune system, adult hippocampal neurogenesis and induce anxiety- depressive-like behaviour in rodents. However, previous studies have not discriminated between effect(s) of different types on these behavioural biological outcomes. We investigated repeated injection vs. permanent social isolation behaviour, responsivity, system functioning neurogenesis, young male mice, found that type exposure does indeed matter. Exposure to 6 weeks resulted an anxiety-like...
Numerous studies have examined links between postnatal neurogenesis and depression using a range of experimental methods to deplete neurogenesis. The antimitotic drug temozolomide (TMZ) has previously been used successfully as an tool in animals adult is regularly on human patients standard chemotherapy for brain cancer. In this study, we wanted evaluate whether TMZ model treatment could affect parameters related animal model. Prevalence rates thought be highly underdiagnosed, with some...
Background:The increasingly recognized role of inflammation in the pathogenesis and prognosis depression has led to a renewed focus on immunomodulatory properties compounds with antidepressant action. Studies have, so far, explored such human blood samples animal models.
This pilot study aimed to evaluate the association of plasma ubiquitin C-terminal hydrolase-L1 (UCH-L1), glial fibrillary acidic protein (GFAP), and S100 calcium-binding B (S100B) with intracranial abnormalities visible on a computed tomography (CT) scan (CT positive) injury severity in acute traumatic brain (TBI). For these purposes, cohort 109 adult TBI patients was recruited within 6 h from event. A hyperacute subcohort 20 who had their blood collected 2 analyzed separately for early...
Repeated lipopolysaccharide exposure is often used in longitudinal preclinical models of depression. However, the potential phenotypic differences from acute depression-mimicking effects are rarely described. This study compared chronic administration doses previously depression research to a new mode escalating dose injections. Adult male BALB/c mice ( n=8/group) were injected intraperitoneally with either single 0.83 mg/kg dose, repeated 0.1 or which escalated weekly 0.33 for six weeks....
Schizophrenia is a neurodevelopmental disorder likely caused by environmental and genetic risk factors but functional interactions between the are unclear. We tested hypothesis that dysbindin-1 (Dtnbp1) gene mutation combined with postnatal exposure to viral mimetic polyI:C results in schizophrenia-related behavioural changes adulthood, mediates polyI:C-induced inflammation subventricular zone (SVZ). Adult Sandy (Sdy, Dtnbp1 mutant) mice given early injections displayed reduced prepulse...
Adult hippocampal neurogenesis is involved in stress-related disorders such as depression, posttraumatic stress disorders, well the mechanism of antidepressant effects. However, molecular mechanisms these associations remain to be fully explored. In this study, unpredictable chronic mild mice resulted a deficit neuronal dendritic tree development and neuroblast migration neurogenic niche. To investigate pathways underlying alteration, genome-wide gene expression changes were assessed...
Antidepressants in general, and fluoxetine particular, increase adult hippocampal neurogenesis (AHN) mice. Here we asked how the antidepressant affects behavior AHN a corticosterone model of depression. In three groups male C57BL/6j mice, administered either vehicle (VEH), (CORT) treatment to induce depression-like state, or plus standard dose (CORT+FLX). Following treatment, mice performed open field test, novelty suppressed feeding (NSF) splash test. Neurogenesis was assessed by means...
Abstract Stem cells and neurogenesis persist in the postnatal adult brain. Adult brain stem can be neuroprotective disease augment hippocampal-dependent cognitive function thus are an important therapeutic target. Although many molecules have been discovered that regulate neurogenesis, few studies attempted to amplify process pharmacologically as a goal. To address this gap, we used murine neurosphere cultures from two major cell niches: subventricular zone (SVZ) subgranular (SGZ). We...