A5047919395- Stress Responses and Cortisol
- Tryptophan and brain disorders
- Diet and metabolism studies
- Neurogenesis and neuroplasticity mechanisms
- Maternal Mental Health During Pregnancy and Postpartum
- Child and Adolescent Psychosocial and Emotional Development
- Neuroinflammation and Neurodegeneration Mechanisms
- Neuroendocrine regulation and behavior
- Gut microbiota and health
- Metabolomics and Mass Spectrometry Studies
- Nutritional Studies and Diet
- Cancer-related cognitive impairment studies
- Cholesterol and Lipid Metabolism
- Health disparities and outcomes
- Anesthesia and Neurotoxicity Research
- Attachment and Relationship Dynamics
- Mental Health Treatment and Access
- Adolescent and Pediatric Healthcare
- Adipose Tissue and Metabolism
- Vitamin D Research Studies
- Hormonal Regulation and Hypertension
- Children's Physical and Motor Development
- GDF15 and Related Biomarkers
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Fatty Acid Research and Health
King's College London
2015-2025
Antenatal depression is associated with a broad range of suboptimal outcomes in offspring, although the underlying mechanisms are not yet understood. Animal studies propose inflammation and glucocorticoids as mediators developmental programming effect prenatal stress on offspring responses, but humans at this stage. Indeed, to date no single study has examined effects rigorously defined, clinically significant Major Depressive Disorder (MDD) pregnancy maternal antenatal inflammatory...
Chronic stress can alter the immune system, adult hippocampal neurogenesis and induce anxiety- depressive-like behaviour in rodents. However, previous studies have not discriminated between effect(s) of different types on these behavioural biological outcomes. We investigated repeated injection vs. permanent social isolation behaviour, responsivity, system functioning neurogenesis, young male mice, found that type exposure does indeed matter. Exposure to 6 weeks resulted an anxiety-like...
Fatty acids play prominent roles in brain function as they participate structural, metabolic and signaling processes. The homeostasis of fatty related pathways is known to be impaired cognitive decline dementia, but the relationship between these disturbances common risk factors, namely ɛ4 allele apolipoprotein E (ApoE-ɛ4) gene sex, remains elusive.In order investigate early alterations associated with acid-related serum metabolome, we here applied targeted metabolomics analysis on a nested...
Numerous studies have examined links between postnatal neurogenesis and depression using a range of experimental methods to deplete neurogenesis. The antimitotic drug temozolomide (TMZ) has previously been used successfully as an tool in animals adult is regularly on human patients standard chemotherapy for brain cancer. In this study, we wanted evaluate whether TMZ model treatment could affect parameters related animal model. Prevalence rates thought be highly underdiagnosed, with some...
BackgroundBrain lipid metabolism appears critical for cognitive aging, but whether alterations in the lipidome relate to decline remains unclear at system level.MethodsWe studied participants from Three-City study, a multicentric cohort of older persons, free dementia time blood sampling, and who provided repeated measures cognition over 12 subsequent years. We measured 189 serum lipids 13 classes using shotgun lipidomics case-control sample on (matched age, sex level education) nested...
The gut microbiome is involved in nutrient metabolism and produces metabolites that, via the gut–brain axis, signal to brain influence cognition. Human studies have so far had limited success identifying early metabolic alterations linked cognitive aging, likely due limitations metabolite coverage or follow-ups. Older persons from Three-City population-based cohort who not been diagnosed with dementia at time of blood sampling were included, repeated measures cognition over 12 subsequent...
First-in-family (FiF) students experience significant barriers to university participation and are less likely seek mental health help. This can contribute increased dropouts when compared non-FiF students. Using a mixed methods approach, we aimed ascertain sources of support underlying factors for the preferences favoured by from UK universities. Answers General Help Seeking Questionnaire (GHSQ) two open-ended questions were collected online. We found that FiF (n=194) more help friends...
Hippocampal neurogenesis (HN) occurs throughout the life course and is important for memory mood. Declining with age, HN plays a pivotal role in cognitive decline (CD), dementia, late-life depression, such that altered could represent neurobiological susceptibility to these conditions. Pertinently, dietary patterns (e.g., Mediterranean diet) and/or individual nutrients vitamin D, omega 3) can modify HN, but also risk CD, depression. Therefore, interaction between diet/nutrition may alter...
During pregnancy multiple biological systems undergo consistent modifications, in particular the hormonal axes and immune system. Moreover, while it is well known that pregnant women suffering from depression show alterations these systems, exact underlying mechanisms are still not clear. For this reason, study, we explored blood transcriptomic profile related pathways 41 with a current diagnosis of depression, 23 women, who were depressed but, because history depressive episodes, considered...
Little is known about the effects of depression before birth on quality mother-infant interaction.To understand whether depression, either in pregnancy or lifetime pregnancy, disrupts postnatal interactions.We recruited 131 pregnant women (51 healthy, 52 with major depressive disorder (MDD) 28 a history MDD but healthy pregnancy), at 25 weeks' gestation. was confirmed Structured Clinical Interview for DSM-IV Disorders. Neonatal behaviour assessed 6 days Behavioural Assessment Scale, and...
Diet is considered an important modulator of cognitive decline and dementia, but the available evidence is, however, still fragmented often inconsistent.
It has become widely accepted that the immune system, and specifically increased levels of inflammation, play a role in development depression. However, not everyone with inflammation develops depression, as all other diseases, there are risk factors may contribute to an vulnerability certain individuals. One such factor could be timing inflammatory exposure. Here, using combination PubMed, EMBASE, Ovid Medline PsycINFO, we systematically reviewed whether exposure medically related utero ,...
Stress exposure during the sensitive period of early development has been shown to program brain and increases risk develop cognitive deficits later in life. We have earlier that early-life stress (ES) leads decline at an adult age, associated with changes hippocampal neurogenesis neuroinflammation. In particular, ES affect rate survival newborn cells life as well microglia, modulating their response immune or metabolic challenges Both these processes possibly contribute ES-induced deficits....
Abstract Introduction Diet and exercise influence the risk of cognitive decline (CD) dementia through food metabolome exercise‐triggered endogenous factors, which use blood as a vehicle to communicate with brain. These factors might act in concert hippocampal neurogenesis (HN) shape CD dementia. Methods Using an vitro assay, we examined effects serum samples from longitudinal cohort (n = 418) on proxy HN readouts their association future across 12‐year period. Results Altered apoptosis...
Environmental factors like diet have been linked to depression and/or relapse risk in later life. This could be partially driven by the food metabolome, which communicates with brain via circulatory system and interacts hippocampal neurogenesis (HN), a form of plasticity implicated aetiology. Despite associations between HN, depression, human data further substantiating this hypothesis are largely missing. Here, we used an vitro model HN test effects serum samples from longitudinal ageing...
The age-associated reduction in the proliferation of neural stem cells has been associated with cognitive decline. Numerous factors have shown to modulate this process, including dietary components. Frequent consumption caffeine correlated an increased risk decline, but further evidence a negative effect on hippocampal progenitor is limited animal models. Here, we used human cell line investigate effects integrity and specifically. five concentrations (0mM=control, 0.1mM~150mg, 0.25mM~400mg,...
Repeated lipopolysaccharide exposure is often used in longitudinal preclinical models of depression. However, the potential phenotypic differences from acute depression-mimicking effects are rarely described. This study compared chronic administration doses previously depression research to a new mode escalating dose injections. Adult male BALB/c mice ( n=8/group) were injected intraperitoneally with either single 0.83 mg/kg dose, repeated 0.1 or which escalated weekly 0.33 for six weeks....
Adult hippocampal neurogenesis is involved in stress-related disorders such as depression, posttraumatic stress disorders, well the mechanism of antidepressant effects. However, molecular mechanisms these associations remain to be fully explored. In this study, unpredictable chronic mild mice resulted a deficit neuronal dendritic tree development and neuroblast migration neurogenic niche. To investigate pathways underlying alteration, genome-wide gene expression changes were assessed...
Background The relationship between ethnic density and psychiatric disorder in postnatal women the UK is unclear. Aims To examine effect of own overall on depression (PND) personality dysfunction. Method Multilevel analysis ethnically mixed community-level data gathered from a sample 2262 mothers screened at 6 weeks postpartum for PND Results Living areas higher was protective against screening positive White ( z =–3.18, P = 0.001), even after adjusting area level deprivation, maternal age,...