A5114374891- Diet and metabolism studies
- Adipokines, Inflammation, and Metabolic Diseases
- Inflammatory Biomarkers in Disease Prognosis
- Neuroinflammation and Neurodegeneration Mechanisms
- Alzheimer's disease research and treatments
- Spinal Cord Injury Research
- Tryptophan and brain disorders
- Neurogenesis and neuroplasticity mechanisms
- Gut microbiota and health
- Traumatic Brain Injury Research
- Spinal Dysraphism and Malformations
- Olfactory and Sensory Function Studies
- Metabolomics and Mass Spectrometry Studies
- Nutritional Studies and Diet
- HIV-related health complications and treatments
- Cardiac Arrest and Resuscitation
- Neurogenetic and Muscular Disorders Research
- Nutrition and Health in Aging
- Sphingolipid Metabolism and Signaling
- GDF15 and Related Biomarkers
- Nuclear Receptors and Signaling
- Neurological Disease Mechanisms and Treatments
- Cerebrovascular and genetic disorders
- Genetics and Neurodevelopmental Disorders
- Neurological Disorders and Treatments
Paracelsus Medical University
2020-2025
Pädagogische Hochschule Salzburg
2017
Neuroinflammation is a major contributor to disease progression in Alzheimer's (AD) and characterized by the activity of brain resident glial cells, particular microglia cells. However, there increasing evidence that peripheral immune cells infiltrate at certain stages AD shape pathology. We recently identified CD8+ T-cells parenchyma APP-PS1 transgenic mice being tightly associated with as well neuronal structures. The functional role however completely unexplored. Here, we demonstrate...
Abstract Peripheral immune cell infiltration into the brain is a prominent feature in aging and various neurodegenerative diseases such as Alzheimer’s disease (AD). As AD progresses, CD8+ T cells infiltrate parenchyma, where they tightly associate with neurons microglia. The functional properties of are largely unknown. To gain further insights putative functions brain, we explored compared transcriptomic profile isolated from blood transgenic (APPswe/PSEN1dE9, line 85 [APP-PS1]) age-matched...
The gut microbiome is involved in nutrient metabolism and produces metabolites that, via the gut–brain axis, signal to brain influence cognition. Human studies have so far had limited success identifying early metabolic alterations linked cognitive aging, likely due limitations metabolite coverage or follow-ups. Older persons from Three-City population-based cohort who not been diagnosed with dementia at time of blood sampling were included, repeated measures cognition over 12 subsequent...
BackgroundBrain lipid metabolism appears critical for cognitive aging, but whether alterations in the lipidome relate to decline remains unclear at system level.MethodsWe studied participants from Three-City study, a multicentric cohort of older persons, free dementia time blood sampling, and who provided repeated measures cognition over 12 subsequent years. We measured 189 serum lipids 13 classes using shotgun lipidomics case-control sample on (matched age, sex level education) nested...
Hippocampal neurogenesis (HN) occurs throughout the life course and is important for memory mood. Declining with age, HN plays a pivotal role in cognitive decline (CD), dementia, late-life depression, such that altered could represent neurobiological susceptibility to these conditions. Pertinently, dietary patterns (e.g., Mediterranean diet) and/or individual nutrients vitamin D, omega 3) can modify HN, but also risk CD, depression. Therefore, interaction between diet/nutrition may alter...
Background/Objectives: Neuroinflammation, a hallmark of Alzheimer's disease (AD), is characterized by elevated levels inflammatory signaling molecules, including cytokines and eicosanoids, as well increased microglial reactivity, augmented gut microbiota dysbiosis via the gut-brain axis. We conducted pilot experiment to elucidate anti-inflammatory effects dietary omega-3 polyunsaturated fatty acid (ω-3 PUFA) eicosapentaenoic (EPA) on neuroinflammation. Methods: Female APP/PS1 mice (TG)...
Dementia with Lewy bodies (DLB) represents a huge medical need as it accounts for up to 30% of all dementia cases, and there is no cure available. The underyling spectrum pathology complex creates challenge targeted molecular therapies. We here tested the hypothesis that leukotrienes are involved in DLB blocking through Montelukast, leukotriene receptor antagonist approved anti-asthmatic drug, might alleviate restore cognitive functions. Expression 5-lipoxygenase, rate-limiting enzyme...
In Alzheimer's disease (AD), platelets become dysfunctional and might contribute to amyloid beta deposition. Here, we depleted in one-year-old APP Swedish PS1 dE9 (APP-PS1) transgenic mice for five days, using intraperitoneal injections of an anti-CD42b antibody, assessed changes cerebral amyloidosis, plaque-associated neuritic dystrophy gliosis. APP-PS1 female mice, platelet depletion shifted plaque size distribution towards bigger plaques increased the hippocampus. platelet-depleted...
Introduction: Alzheimer’s disease (AD) and aging are associated with platelet hyperactivity. However, the mechanisms underlying abnormal function in AD yet poorly understood. Methods: To explore molecular profile of aged platelets, we investigated activation (i.e., CD62P expression), proteome transcriptome patients, non-demented elderly, young individuals as controls. Results: AD, showed similar levels based on expression. had a proteomic signature suggestive increased compared...
Abstract Introduction Diet and exercise influence the risk of cognitive decline (CD) dementia through food metabolome exercise‐triggered endogenous factors, which use blood as a vehicle to communicate with brain. These factors might act in concert hippocampal neurogenesis (HN) shape CD dementia. Methods Using an vitro assay, we examined effects serum samples from longitudinal cohort (n = 418) on proxy HN readouts their association future across 12‐year period. Results Altered apoptosis...
Environmental factors like diet have been linked to depression and/or relapse risk in later life. This could be partially driven by the food metabolome, which communicates with brain via circulatory system and interacts hippocampal neurogenesis (HN), a form of plasticity implicated aetiology. Despite associations between HN, depression, human data further substantiating this hypothesis are largely missing. Here, we used an vitro model HN test effects serum samples from longitudinal ageing...
The age-associated reduction in the proliferation of neural stem cells has been associated with cognitive decline. Numerous factors have shown to modulate this process, including dietary components. Frequent consumption caffeine correlated an increased risk decline, but further evidence a negative effect on hippocampal progenitor is limited animal models. Here, we used human cell line investigate effects integrity and specifically. five concentrations (0mM=control, 0.1mM~150mg, 0.25mM~400mg,...
Neurological examination in the acute phase after spinal cord injury (SCI) is often impossible and severely confounded by pharmacological sedation or concomitant injuries. Therefore, diagnostic biomarkers that objectively characterize severity presence of SCI are urgently needed to facilitate clinical decision-making. This study aimed determine if serum markers neural origin related to: 1) SCI, 2) magnetic resonance imaging (MRI) parameters very post-injury phase. We performed a secondary...
The use of biomarkers in spinal cord injury (SCI) research has evolved rapidly recent years whereby most studies focused on the acute post-injury phase. Since SCI is characterized by persisting neurological impairments, question arises whether blood remain altered during subacute time. Sample collection phase might provide a better insight ongoing specific molecular mechanism with fewer confounding factors compared where, amongst other complications, individuals receive substantial amount...
Adult neurogenesis is a target for brain rejuvenation as well regeneration in aging and disease. Numerous approaches showed efficacy to elevate rodents, yet translation into therapies has not been achieved. Here, we introduce novel human TGFβ-RII (Transforming Growth Factor-Receptor Type II) specific LNA-antisense oligonucleotide ("locked nucleotide acid"-"NVP-13"), which reduces expression downstream receptor signaling neuronal precursor cells (ReNcell CX® cells) vitro. After injected...
Neurodegenerative diseases are associated with increased neuroinflammation. Leukotrienes small lipid mediators of neuroinflammatory processes, and thus, leukotriene signaling might be a therapeutic target for neurodegenerative disease such as AD, PD, or Lewy body dementia (LBD). 6-month old PDGF-promoter-alpha-synuclein (PDGF-a-syn) D-line transgenic mice (abbreviated D-line), an animal model LBD, were treated per oral gavage daily over period 42 days montelukast (10 mg/kg), approved...
Abstract Background The microbiome is involved in nutrient metabolism and releases metabolites that can influence cognitive aging, likely through the gut‐brain axis. Human studies, generally limited number of follow‐up, have been inadequate to identify early metabolic alterations leading aging. aim this study was investigate association between circulating levels a large microbial plasma decline. Methods We studied participants from Three‐City study, cohort conducted 3 French cities...