A5066086975- Muscle metabolism and nutrition
- Adipokines, Inflammation, and Metabolic Diseases
- Inflammatory Biomarkers in Disease Prognosis
- Diet and metabolism studies
- Exercise and Physiological Responses
- Neuroinflammation and Neurodegeneration Mechanisms
- Biochemical Analysis and Sensing Techniques
- Olfactory and Sensory Function Studies
- Neurogenesis and neuroplasticity mechanisms
- Biochemical effects in animals
- Advanced Chemical Sensor Technologies
- Neurotransmitter Receptor Influence on Behavior
- Metabolism, Diabetes, and Cancer
- Receptor Mechanisms and Signaling
- Neuroscience and Neuropharmacology Research
- Mesenchymal stem cell research
- Chemokine receptors and signaling
- Genetics, Aging, and Longevity in Model Organisms
- Extracellular vesicles in disease
- Muscle Physiology and Disorders
- Regulation of Appetite and Obesity
- Cell Adhesion Molecules Research
- HER2/EGFR in Cancer Research
- Memory and Neural Mechanisms
- Peptidase Inhibition and Analysis
University of California, San Francisco
2019-2025
West Virginia University
2016-2021
James Madison University
2014-2016
Committee on Publication Ethics
2014
Plasma transfers exercise benefit in mice Exercise has a broad range of beneficial healthful effects. Horowitz et al. tested whether the effects on neurogenesis brain and improved cognition aged could be transferred plasma (blood without its cellular components) from one mouse to another (see Perspective by Ansere Freeman). Indeed, that received young or old had exercised showed their brains hitting treadmill. The authors identified glycosylphosphatidylinositol-specific phospholipase D1 as...
Identifying therapeutics to delay, and potentially reverse, age-related cognitive decline is critical in light of the increased incidence dementia-related disorders forecasted growing older population1. Here we show that platelet factors transfer benefits young blood ageing brain. Systemic exposure aged male mice a fraction plasma from containing platelets decreased neuroinflammation hippocampus at transcriptional cellular level ameliorated hippocampal-dependent impairments. Circulating...
Abstract The beneficial effects of physical activity on brain ageing are well recognised, with exerkines, factors that secreted into the circulation in response to exercise, emerging as likely mediators this response. However, source and identity these exerkines remain unclear. Here we provide evidence an anti-geronic exerkine is by platelets. We show platelets activated exercise required for exercise-induced increase hippocampal precursor cell proliferation aged mice. also demonstrate...
The effects of glucose-and-fructose (GF) coingestion on cycling time trial (TT) performance and physiological responses to exercise were examined under postprandial conditions.Eight trained male cyclists (age, 25 ± 6 yr; height, 180 4 cm; weight, 77 9 kg; V˙O2max, 62 mL·kg·min) completed the study. Subjects ingested either an artificially sweetened placebo (PL), a moderate-glucose beverage (MG, 1.03 g·min), high-glucose (HG, 1.55 or GF (1.55 g·min, 2:1 ratio) during approximately 3 h...
There is good evidence that mouth rinsing with carbohydrate (CHO) solutions can enhance endurance performance (≥30 min). The impact of a CHO rinse on sprint has been less consistent, suggesting may confer benefits in conditions 'metabolic strain'. To test this hypothesis, the current study examined late-exercise performance. Secondly, we investigated effects protein (PRO) Eight trained male cyclists participated three trials consisting 120 min constant-load cycling (55% Wmax) followed by 30...
Introduction: Alzheimer’s disease (AD) and aging are associated with platelet hyperactivity. However, the mechanisms underlying abnormal function in AD yet poorly understood. Methods: To explore molecular profile of aged platelets, we investigated activation (i.e., CD62P expression), proteome transcriptome patients, non-demented elderly, young individuals as controls. Results: AD, showed similar levels based on expression. had a proteomic signature suggestive increased compared...
Regulators of G protein signaling are proteins that accelerate the termination effector stimulation after protein-coupled receptor activation. Many regulators highly expressed in brain and therefore considered potential drug discovery targets for central nervous system pathologies; example, here we show RGS12 is microdissected mouse ventral striatum. Given a role striatum psychostimulant-induced locomotor activity, tested whether Rgs12 genetic ablation affected behavioral responses to...
Regulators of G Protein Signaling (RGS proteins) inhibit protein-coupled receptor (GPCR) signaling by accelerating the GTP hydrolysis rate activated Gα subunits. Some RGS proteins exert additional signal modulatory functions, and RGS12 is one such protein, with five additional, functional domains: a PDZ domain, phosphotyrosine-binding two Ras-binding domains, Gα·GDP-binding GoLoco motif. expression temporospatially regulated in developing mouse embryos, notable somites skeletal muscle. We...
Previous studies reported that adding protein (PRO) to carbohydrate (CHO) solutions enhances endurance performance. The ergogenic effect may be a function of additional protein/amino acid calories, but this has not been examined. In addition, although supplemental L-alanine (ALA) is readily oxidized during exercise, the subsequent impact on metabolism and prolonged performance unknown. purpose investigation was independently gauge whey PRO hydrolysate ALA supplementation various...
The mammalian tastes of sweet, umami, and bitter are initiated by activation G protein-coupled receptors (GPCRs) the T1R T2R families on taste receptor cells. GPCRs signal via nucleotide exchange hydrolysis, latter hastened GTPase-accelerating proteins (GAPs) that include Regulators protein Signaling (RGS) family. We previously reported RGS21, uniquely expressed in Type II cells, decreases potency bitter-stimulated signaling cultured consistent with its vitro GAP activity. However, role...
Abstract The T1R and T2R families of G protein-coupled receptors (GPCRs) initiate tastant perception by signaling via guanine nucleotide exchange hydrolysis performed associated heterotrimeric proteins (Gαβγ). Heterotrimeric protein signal termination is sped up Gα-directed GTPase-accelerating (GAPs) known as the Regulators Signaling (RGS proteins). Of this family, RGS21 highly expressed in lingual epithelial cells we have shown it acting vitro to decrease potency bitterants on cultured...
Rheumatoid arthritis (RA) is a chronic and debilitating disease mediated by dysregulated recruitment activation of immune cells. G Protein Signaling Modulator 3 (GPSM3) restricted in its expression to leukocytes, with greatest occurring monocytes neutrophils ‐‐ cell lineages paramount RA pathogenesis. Notably, two human GPSM3 single‐nucleotide polymorphisms (SNPs) are associated decreased likelihood developing RA. We found that whole blood mRNA isolated from volunteers homozygous for these...