A5070520510- Nutritional Studies and Diet
- Diet and metabolism studies
- Metabolomics and Mass Spectrometry Studies
- Cancer survivorship and care
- COVID-19 and healthcare impacts
- Nutrition and Health in Aging
- COVID-19 and Mental Health
- Cancer-related cognitive impairment studies
- Health, Environment, Cognitive Aging
- Dementia and Cognitive Impairment Research
- Gut microbiota and health
- Folate and B Vitamins Research
- Eicosanoids and Hypertension Pharmacology
- Cholesterol and Lipid Metabolism
- Cancer, Stress, Anesthesia, and Immune Response
- Fatty Acid Research and Health
- Vagus Nerve Stimulation Research
- Posttraumatic Stress Disorder Research
- Alcohol Consumption and Health Effects
- Coffee research and impacts
- Heart Rate Variability and Autonomic Control
- Ovarian cancer diagnosis and treatment
- Anesthesia and Neurotoxicity Research
- Neurogenesis and neuroplasticity mechanisms
- Tryptophan and brain disorders
Bordeaux Population Health
2016-2025
Université de Bordeaux
2017-2024
Institut de Recherche en Santé, Environnement et Travail
2021-2024
Inserm
2016-2024
Centre François Baclesse
2021-2023
Normandie Université
2021-2023
Cancers et Préventions
2023
Unité de recherche interdisciplinaire pour la prévention et le traitement des cancers
2021-2023
Methodology and Quality of Life Unit in Oncology
2023
Université de Caen Normandie
2021-2022
Fatty acids play prominent roles in brain function as they participate structural, metabolic and signaling processes. The homeostasis of fatty related pathways is known to be impaired cognitive decline dementia, but the relationship between these disturbances common risk factors, namely ɛ4 allele apolipoprotein E (ApoE-ɛ4) gene sex, remains elusive.In order investigate early alterations associated with acid-related serum metabolome, we here applied targeted metabolomics analysis on a nested...
To investigate the optimal combination of dietary polyphenols associated with long-term risk dementia in a large prospective French cohort older persons, Three-City (3C) Study.We included 1,329 adults without from 3C study assessment intake 26 polyphenol subclasses who were followed up for 12 years dementia. Using partial least squares Cox models, we identified pattern risk.The combined several flavonoids (dihydroflavonols, anthocyanins, isoflavonoids, flavanones), stilbenes (including...
BackgroundBrain lipid metabolism appears critical for cognitive aging, but whether alterations in the lipidome relate to decline remains unclear at system level.MethodsWe studied participants from Three-City study, a multicentric cohort of older persons, free dementia time blood sampling, and who provided repeated measures cognition over 12 subsequent years. We measured 189 serum lipids 13 classes using shotgun lipidomics case-control sample on (matched age, sex level education) nested...
The gut microbiome is involved in nutrient metabolism and produces metabolites that, via the gut–brain axis, signal to brain influence cognition. Human studies have so far had limited success identifying early metabolic alterations linked cognitive aging, likely due limitations metabolite coverage or follow-ups. Older persons from Three-City population-based cohort who not been diagnosed with dementia at time of blood sampling were included, repeated measures cognition over 12 subsequent...
Hippocampal neurogenesis (HN) occurs throughout the life course and is important for memory mood. Declining with age, HN plays a pivotal role in cognitive decline (CD), dementia, late-life depression, such that altered could represent neurobiological susceptibility to these conditions. Pertinently, dietary patterns (e.g., Mediterranean diet) and/or individual nutrients vitamin D, omega 3) can modify HN, but also risk CD, depression. Therefore, interaction between diet/nutrition may alter...
B vitamins may lower the risk of dementia, yet epidemiological findings, mostly from countries with folic acid fortification, have remained inconsistent. We evaluated in a large French cohort older persons associations between dietary and long-term incident dementia. included 1321 participants Three-City Study who completed 24 h recall, were free dementia at time diet assessment, followed for an average 7.4 years. In Cox proportional hazards models adjusted multiple potential confounders,...
Untargeted metabolomics may reveal preventive targets in cognitive aging, including within the food metabolome.
Diet is considered an important modulator of cognitive decline and dementia, but the available evidence is, however, still fragmented often inconsistent.
Abstract Introduction Several nutrients may predict dementia risk. We characterized nutrient biomarker patterns, which integrate the complexity of exposure and biodisponibility associated with long‐term risk in a large cohort older persons, Three‐City study. Methods included 666 nondemented participants plasma measurements 22 fat‐soluble at baseline, who were followed up for 12 years dementia. Results A “deleterious” pattern combining lower blood status vitamin D, carotenoids,...
Diet has been recognized as a modifiable risk factor for breast cancer. Highlighting predictive diet-related biomarkers would be of great public health relevance to identify at-risk subjects. The aim this exploratory study was select metabolites discriminating women at higher cancer using untargeted metabolomics.
Background The COVID‐19 pandemic may induce post‐traumatic stress disorder (PTSD) symptoms among patients with cancer, who also face adaptations to their treatment. authors assessed the occurrence of PTSD symptoms, investigated pandemic‐induced adjustments in medical oncology practice and explored risk factors for association between insomnia, quality life (QoL). Methods This prospective French study was conducted solid/hematologic tumors were receiving treatment day care departments 2...
Metabolic syndrome (MetS) is a complex condition encompassing constellation of cardiometabolic abnormalities. Oxylipins are superfamily lipid mediators regulating many functions. Plasma oxylipin signature could provide new clinical tool to enhance the phenotyping MetS pathophysiology. A high-throughput validated mass spectrometry method, allowing for quantitative profiling over 130 oxylipins, was applied identify and validate in two independent nested case/control studies involving 476...
Identifying new modifiable prognostic markers is important for ovarian cancer (OC). Low parasympathic activity associated with inflammation, oxidative stress and sympathetic nervous system activation. Previous studies reported that low vagal nerve activity, measured by heart rate variability (HRV), may predict poor prognosis. We aimed to examine the value of HRV in OC.This bicentric retrospective study included patients diagnosed serous OC FIGO stage ≥IIB, between January 2015 August 2019,...
Stress exposure during the sensitive period of early development has been shown to program brain and increases risk develop cognitive deficits later in life. We have earlier that early-life stress (ES) leads decline at an adult age, associated with changes hippocampal neurogenesis neuroinflammation. In particular, ES affect rate survival newborn cells life as well microglia, modulating their response immune or metabolic challenges Both these processes possibly contribute ES-induced deficits....
To use network science to model complex diet relationships a decade before onset of dementia in large French cohort, the 3-City Bordeaux study.We identified cases incident baseline food frequency questionnaire over 12 years follow-up. For each case, we randomly selected 2 controls among individuals at risk age case diagnosis and matched for assessment, sex, education, season survey. We inferred networks both using mutual information, measure detect nonlinear associations, compared...
Abstract Introduction Diet and exercise influence the risk of cognitive decline (CD) dementia through food metabolome exercise‐triggered endogenous factors, which use blood as a vehicle to communicate with brain. These factors might act in concert hippocampal neurogenesis (HN) shape CD dementia. Methods Using an vitro assay, we examined effects serum samples from longitudinal cohort (n = 418) on proxy HN readouts their association future across 12‐year period. Results Altered apoptosis...
Environmental factors like diet have been linked to depression and/or relapse risk in later life. This could be partially driven by the food metabolome, which communicates with brain via circulatory system and interacts hippocampal neurogenesis (HN), a form of plasticity implicated aetiology. Despite associations between HN, depression, human data further substantiating this hypothesis are largely missing. Here, we used an vitro model HN test effects serum samples from longitudinal ageing...
Using the large nationwide French, national, multicenter, prospective cancer and toxicities (CANTO) cohort, we assessed cognitive functioning change after treatments in a subgroup of breast (BC) patients.We included patients with newly diagnosed invasive stage I-III BC enrolled CANTO substudy focused on evaluation healthy control women matched for age education. Episodic working memory, executive functions, processing speed, attention, self-report difficulties (SRCD), fatigue, anxiety...
Background: Patients with cancer may be particularly vulnerable to psychological consequences of the COVID-19 pandemic. We studied prevalence and evolution posttraumatic stress symptoms (PTSS) in patients during pandemic waves, we investigated factors associated high symptoms. Methods: COVIPACT is a 1-year longitudinal prospective study French solid/hematologic malignancies receiving treatment first nationwide lockdown. PTSS were measured every 3 months from April 2020 using Impact Event...
Cancer-related cognitive impairment (CRCI) is a frequent side-effect of cancer treatment, with important consequences on patients' quality life. Cognitive stimulation and physical activity are the most efficient in improving impairment, but they challenging to generalize hospitals' routine needs schedules. Moreover, added value combination these interventions be more investigated. The Cog-Stim study an interventional investigating feasibility web-based multimodal intervention (combining for...