A5072407480- Retinal Diseases and Treatments
- Retinal Imaging and Analysis
- Antioxidant Activity and Oxidative Stress
- Glaucoma and retinal disorders
- Nutritional Studies and Diet
- Retinoids in leukemia and cellular processes
- Retinal and Optic Conditions
- Ophthalmology and Visual Impairment Studies
- Diet and metabolism studies
- Eicosanoids and Hypertension Pharmacology
- Fatty Acid Research and Health
- Ocular Diseases and Behçet’s Syndrome
- Vitamin D Research Studies
- Nutrition and Health in Aging
- Sleep and Work-Related Fatigue
- Sleep and related disorders
- Consumer Attitudes and Food Labeling
- Connective tissue disorders research
- Retinal Development and Disorders
- melanin and skin pigmentation
- Cancer, Lipids, and Metabolism
- Bone Metabolism and Diseases
- Cholesterol and Lipid Metabolism
- Adversarial Robustness in Machine Learning
- Edible Oils Quality and Analysis
Bordeaux Population Health
2016-2025
Université de Bordeaux
2015-2024
Inserm
2015-2024
Université Claude Bernard Lyon 1
2020-2021
Tufts Medical Center
2015-2017
Hôpital Intercommunal de Créteil
2013-2016
Université Paris-Est Créteil
2013-2016
Paris-Est Sup
2015
Hôpital Universitaire Dupuytren
1992
Hypovitaminosis D has been associated with several chronic conditions; yet, its association cognitive decline and the risk of dementia Alzheimer's disease (AD) inconsistent.The study population consisted 916 participants from Three-City Bordeaux cohort aged 65+, nondemented at baseline, assessment vitamin status who were followed for up to 12 years.In multivariate analysis, compared individuals 25(OH)D sufficiency (n = 151), deficiency 218) exhibited a faster decline. A total 177 cases (124...
We assessed the associations of serum, red blood cell membranes (RBCM) and dietary long-chain n-3 polyunsaturated fatty acids (LC-PUFAs) with neovascular age-related macular degeneration (AMD).We included 290 patients Nutritional AMD Treatment 2 Study (NAT2) in one eye early lesions other eye, 144 normal vision controls without AMD. Dietary intake seafood was estimated by food frequency questionnaire. Eicosapentaenoic acid (EPA) docosahexaenoic (DHA) composition serum RBCM were determined...
PurposeAge-related macular degeneration (AMD) is a common multifactorial disease in the elderly with prominent genetic basis. Many risk variants have been identified, but interpretation remains challenging. We investigated distribution of AMD-associated large European consortium, calculated attributable and pathway-specific risks, assessed influence lifestyle on outcomes.DesignPooled analysis cross-sectional data from Eye Epidemiology Consortium.ParticipantsSeventeen thousand one hundred...
While the prevalence of age-related macular degeneration (AMD) differs according to continents and races/ethnicities, its incidence in European continent has been scarcely documented.To describe associated risk factors AMD elderly French individuals.This population-based cohort study 963 residents Bordeaux, France, who were 73 years or older at baseline participated Antioxydants, Lipides Essentiels, Nutrition et Maladies Oculaires (ALIENOR) Study between October 2, 2006, December 21, 2012....
<h3>Purpose</h3> To compare different imaging modalities and to investigate the ability of MultiColor evaluate geographic atrophy (GA) due age-related macular degeneration (AMD). <h3>Methods</h3> Twenty-two consecutive patients with GA underwent MultiColor, colour fundus photography, blue autofluorescence (FAF) (excitation=488 nm; emission >500 nm), near-infrared FAF (NIR-FAF) (excitation=787 >800 nm) spectral-domain optical coherence tomography (SD-OCT) (Spectralis HRA+OCT; Heidelberg...
PurposeThe current study aimed to identify metabolites associated with age-related macular degeneration (AMD) by performing the largest metabolome association analysis in AMD date, as well aiming determine effect of AMD-associated genetic variants on metabolite levels and investigate associations between identified activity complement system, one main disease pathways.DesignCase-control metabolomics data.ParticipantsFive European cohorts consisting 2267 patients 4266 control...
PurposeTo develop a genotype assay to assess associations with common and rare age-related macular degeneration (AMD) risk variants, calculate an overall genetic score (GRS), identify potential misdiagnoses inherited dystrophies that mimic AMD.DesignCase-control study.ParticipantsIndividuals (n = 4740) from 5 European cohorts.MethodsWe designed single-molecule molecular inversion probes for target selection used next generation sequencing sequence 87 single nucleotide polymorphisms (SNPs),...
Previous studies have suggested a lower risk for age-related maculopathy (ARM) in subjects with high dietary intake of long-chain omega-3 polyunsaturated fatty acids (PUFA). The authors report the associations ARM past intakes French elderly subjects.The Alienor Study is population-based epidemiologic study on nutrition and eye diseases performed residents Bordeaux 73 years age older. Six hundred sixty-six (1289 eyes) complete data were included analyses. was classified from retinal...
Purpose: There is growing evidence of the importance nutrition in age-related macular degeneration (AMD), but no prospective studies have explored impact vitamin D. We evaluated association between D intake and progression to advanced AMD. Methods: Among 2146 participants (3965 eyes), 541 (777 eyes) progressed from early or intermediate AMD disease (mean follow-up: 9.4 years) based on ocular imaging. Nutrients were log transformed calorie adjusted. Survival analysis was used assess...
Nutritional uptake of lutein, zeaxanthin, and ω-3 polyunsaturated fatty acids may increase macular pigment optical density (MPOD) thereby protect against the development age-related degeneration (AMD).To estimate efficiency dietary supplementation containing acids, vitamins to in first-generation offspring parents with neovascular AMD.This study was a randomized clinical trial (Lutein Influence on Macula Persons Issued From AMD Parents [LIMPIA]) 6-month treatment period, followed by...
Lutein and zeaxanthin may lower the risk of age-related macular degeneration (AMD). We evaluated associations plasma lutein with incidence advanced AMD in Alienor study (Antioxydants Lipides Essentiels Nutrition et Maladies Oculaires). is a prospective population-based cohort 963 residents Bordeaux, France, who were 73 years or older at baseline (2006–2008). The present included 609 participants complete ophthalmologic carotenoids data. Examinations performed every two over an eight-year...