A5048643994- Retinal Diseases and Treatments
- Retinal Imaging and Analysis
- Glaucoma and retinal disorders
- Retinal and Optic Conditions
- Retinal Development and Disorders
- Corneal surgery and disorders
- Ocular Diseases and Behçet’s Syndrome
- Ophthalmology and Visual Impairment Studies
- Antioxidant Activity and Oxidative Stress
- melanin and skin pigmentation
- Intraocular Surgery and Lenses
- Acute Ischemic Stroke Management
- Cerebral Venous Sinus Thrombosis
- Retinoids in leukemia and cellular processes
- Optical Coherence Tomography Applications
- Retinopathy of Prematurity Studies
- Retinal and Macular Surgery
- Cardiovascular Health and Disease Prevention
- Phytoplasmas and Hemiptera pathogens
- Systemic Lupus Erythematosus Research
- Academic integrity and plagiarism
- Adipose Tissue and Metabolism
- Traditional Chinese Medicine Analysis
- Bioinformatics and Genomic Networks
- Vasculitis and related conditions
Hospital Quirón Teknon
2012-2024
Barcelona Macula Foundation
2013-2023
University of Coimbra
2017
Institut Català de Retina
2011-2015
Universitat Pompeu Fabra
2011-2015
Roche (Switzerland)
2015
Novartis (Switzerland)
2015
Alcon (China)
2015
Bayer (United States)
2015
Topcon (Netherlands)
2015
PurposeThe current study aimed to identify metabolites associated with age-related macular degeneration (AMD) by performing the largest metabolome association analysis in AMD date, as well aiming determine effect of AMD-associated genetic variants on metabolite levels and investigate associations between identified activity complement system, one main disease pathways.DesignCase-control metabolomics data.ParticipantsFive European cohorts consisting 2267 patients 4266 control...
PurposeTo develop a genotype assay to assess associations with common and rare age-related macular degeneration (AMD) risk variants, calculate an overall genetic score (GRS), identify potential misdiagnoses inherited dystrophies that mimic AMD.DesignCase-control study.ParticipantsIndividuals (n = 4740) from 5 European cohorts.MethodsWe designed single-molecule molecular inversion probes for target selection used next generation sequencing sequence 87 single nucleotide polymorphisms (SNPs),...
To establish the dose of subretinal sodium iodate (NaIO3) in order to create a toxin-induced large animal model selective circumscribed atrophy outer retinal layers, pigment epithelium (RPE), and photoreceptors, by spectral-domain optical coherence tomography (SD-OCT) immunocytochemistry.Fifteen male female healthy Yorkshire pigs received unilateral escalating doses NaIO3 under general anesthesia. In all animals, volumes 0.1 0.2 mL were injected into space area centralis through 23/38-gauge...
Geographic atrophy (GA) secondary to age-related macular degeneration is considered a single entity. This study aimed determine whether GA subgroups exist that can be defined by their genotype and phenotype.Retrospective analysis of cross-sectional data.Individuals (196 eyes 196 patients) 50 years age or older with from the EYE-RISK database.Participants were graded for presence each following fundus features on color photography: large soft drusen, reticular pseudodrusen (RPD), refractile...
Geographic atrophy (GA) secondary to age-related macular degeneration is a common cause of blindness worldwide. Given the recent approval first therapy for GA, pegcetacoplan, we critically appraise methodological aspects phase 3 clinical trials published so far in this disease relation their design, analysis and interpretation. We reviewed some key attributes all GA available main public registry as 20 May 2023. The topics discussed included types endpoints, eligibility criteria, p-value...
Treatments for geographic atrophy (GA), a late stage of age-related macular degeneration (AMD), are currently under development. Understanding the natural course is needed optimal trial design. Although enlargement rates GA and visual acuity (VA) in short term known from clinical studies, knowledge long term, life expectancy, lacking.To determine long-term GA.In this study, participant data were collected 4 population-based cohort with up to 25 years follow-up eye examinations at 5-year...
To determine the relationship between progression of geographic atrophy (GA) and its baseline area (BA) using square root transformation (sqrt) for different sizes.Single eyes patients with GA visiting Institut de la Màcula (Barcelona, Spain) December 2009 January 2018 a follow-up ≥6 months were included. The main outcome was correlation BA growth after sqrt Pearson's r Spearman's rho. graphical explored linear LOWESS regression. In secondary, prespecified analysis, compared by categories...
The aim of this study was to test the feasibility and safety subretinal transplantation human induced pluripotent stem cell (hiPSC)-derived retinal pigment epithelium (RPE) cells into healthy margins within areas degenerative retina in a swine model geographic atrophy (GA).Well-delimited selective outer damage by injection NaIO3 one eye minipigs (n = 10). Thirty days later, suspension hiPSC-derived RPE expressing green fluorescent protein injected space, margins, retina. In vivo follow-up...
To identify objective glaucoma-related structural features based on peripapillary (p) and macular (m) spectral domain optical coherence tomography (SD-OCT) parameters assess their discriminative ability between healthy glaucoma patients.Two hundred sixty eyes (91 controls 169 glaucoma) were included in this prospective study. After a complete examination, all participants underwent the posterior pole retinal nerve fibre layer (pRNFL) protocols of Spectralis SD-OCT. Principal component...
To investigate the safety and efficacy of a combined fixed-interval pro re nata regimen ranibizumab (FUSION regimen) for treatment exudative age-related macular degeneration in patients with good visual acuity at baseline. establish whether similar to monthly regimens can be achieved fewer injections, even acuity.This was prospective, open-label, consecutive interventional case series treatment-naïve degeneration. The FUSION consists three phases: 1) loading phase two or depending on...
To describe a subgroup of subjects with soft drusen associated geographic atrophy (GA) and novel spectral-domain OCT (SD-OCT) findings consistent presumed leakage. We also propose mechanism leading to GA progression in these patients.A retrospective, observational cohort study.Forty-eight eyes 33 patients secondary age-related macular degeneration (AMD).Drusen were evaluated SD-OCT retinal imaging characterize the development atrophy-associated regression (drusen collapse) over follow-up...
BackgroundDrusen are seen in the early and intermediate stages of age‐related macular degeneration. A retrospective, two‐year observational study at a tertiary centre was designed to assess outer nuclear layer thickness different types drusen.MethodsPatients over 50-years age with predominant soft drusen or reticular pseudodrusen were included study. Fundus photography, infrared, fundus autofluorescence spectral domain optical coherence tomography performed baseline, years one two. Outer...
Purpose . To analyse the vascular density of choroid in a keratoconus (KC) population using swept-source optical coherence tomography (SS-OCT). Methods Prospective, noninterventional study that analysed 97 eyes from 52 KC patients and 145 89 healthy controls. The sample was divided four different age groups. Inclusion criteria were topographic diagnosis Pentacam, axial length shorter than 26 mm, good quality images, no other systemic or ocular diseases. A 12 mm horizontal single-line SS-OCT...