Anneke I. den Hollander
A5049656883- Retinal Diseases and Treatments
- Retinal Development and Disorders
- Retinal Imaging and Analysis
- Glaucoma and retinal disorders
- Ocular Diseases and Behçet’s Syndrome
- Complement system in diseases
- Metabolomics and Mass Spectrometry Studies
- Retinal and Optic Conditions
- Systemic Lupus Erythematosus Research
- Connexins and lens biology
- Ocular Disorders and Treatments
- Retinoids in leukemia and cellular processes
- Genetic Associations and Epidemiology
- Retinopathy of Prematurity Studies
- Photoreceptor and optogenetics research
- Antioxidant Activity and Oxidative Stress
- Hippo pathway signaling and YAP/TAZ
- Advanced biosensing and bioanalysis techniques
- Mosquito-borne diseases and control
- Cellular transport and secretion
- melanin and skin pigmentation
- Corneal surgery and disorders
- Renal Diseases and Glomerulopathies
- CRISPR and Genetic Engineering
- Lipid metabolism and disorders
Radboud University Nijmegen
2016-2025
Radboud University Medical Center
2016-2025
AbbVie (United States)
2022-2025
Lake County
2023
Philips (Netherlands)
2013-2022
University Medical Center
2014-2022
Genomics (United Kingdom)
2022
University of Antwerp
2016
Isra University
2016
Antwerp University Hospital
2016
Molecular diagnostics for patients with retinitis pigmentosa (RP) has been hampered by extreme genetic and clinical heterogeneity, 52 causative genes known to date. Here, we developed a comprehensive next-generation sequencing (NGS) approach the molecular of RP. All inherited retinal disease (n = 111) were captured simultaneously analyzed using NGS in 100 RP without diagnosis. A systematic data analysis pipeline was validated prioritize predict pathogenicity all variants identified each...
Abstract Genome-wide association analyses using high-throughput metabolomics platforms have led to novel insights into the biology of human metabolism 1–7 . This detailed knowledge genetic determinants systemic has been pivotal for uncovering how pathways influence biological mechanisms and complex diseases 8–11 Here we present a genome-wide study 233 circulating metabolic traits quantified by nuclear magnetic resonance spectroscopy in up 136,016 participants from 33 cohorts. We identify...
Chronic central serous chorioretinopathy: long-term follow-up and vision-related quality of life Myrte B Breukink,1,* Alexander JM Dingemans,1,* Anneke I den Hollander,1,2 Jan EE Keunen,1 Robert E MacLaren,3,4 Sascha Fauser,5 Giuseppe Querques,6 Carel Hoyng,1 Susan M Downes,3,4 Camiel JF Boon1,7 1Department Ophthalmology, 2Department Human Genetics, Radboud University Medical Center, Nijmegen, the Netherlands; 3Oxford Eye Hospital, Oxford Hospitals NHS Trust, 4Nuffield Laboratory...