Lawrence F. Bielak
- Genetic Associations and Epidemiology
- Metabolomics and Mass Spectrometry Studies
- Cardiac Imaging and Diagnostics
- Epigenetics and DNA Methylation
- Genetic and phenotypic traits in livestock
- Genetic Mapping and Diversity in Plants and Animals
- Liver Disease Diagnosis and Treatment
- Nutrition, Genetics, and Disease
- Cardiovascular Disease and Adiposity
- Genomics and Rare Diseases
- Bioinformatics and Genomic Networks
- Birth, Development, and Health
- RNA modifications and cancer
- Cardiovascular Function and Risk Factors
- Lipid metabolism and disorders
- Lipid metabolism and biosynthesis
- Lipoproteins and Cardiovascular Health
- Cancer-related molecular mechanisms research
- Pancreatic function and diabetes
- Adipose Tissue and Metabolism
- Atherosclerosis and Cardiovascular Diseases
- Cardiovascular Health and Disease Prevention
- Diet, Metabolism, and Disease
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Alcohol Consumption and Health Effects
University of Michigan
2016-2025
Harvard University
2007-2023
Ferrer Grupo (Spain)
2020
Economic History Society
2020
Michigan United
2013-2019
Brigham and Women's Hospital
2017
Centre National de la Recherche Scientifique
2015
European Genomic Institute for Diabetes
2015
Authorised Association Consortium
2014
The University of Texas Health Science Center at Houston
2002-2013
Abstract The Trans-Omics for Precision Medicine (TOPMed) programme seeks to elucidate the genetic architecture and biology of heart, lung, blood sleep disorders, with ultimate goal improving diagnosis, treatment prevention these diseases. initial phases focused on whole-genome sequencing individuals rich phenotypic data diverse backgrounds. Here we describe TOPMed goals design as well available resources early insights obtained from sequence data. include a variant browser, genotype...
Apolipoprotein C-III (apoC-III) inhibits triglyceride hydrolysis and has been implicated in coronary artery disease. Through a genome-wide association study, we have found that about 5% of the Lancaster Amish are heterozygous carriers null mutation (R19X) gene encoding apoC-III ( APOC3 ) and, as result, express half amount present noncarriers. Mutation compared with noncarriers had lower fasting postprandial serum triglycerides, higher levels HDL-cholesterol LDL-cholesterol. Subclinical...
Common single-nucleotide polymorphisms (SNPs) are predicted to collectively explain 40-50% of phenotypic variation in human height, but identifying the specific variants and associated regions requires huge sample sizes
Background Electron-beam CT (EBCT) quantification of coronary artery calcification (CAC) allows noninvasive assessment atherosclerosis. We undertook a follow-up study to determine whether CAC extent, measured at the time angiography by EBCT, predicted future hard cardiac events, comprising death and nonfatal myocardial infarction (MI). also assessed potential selected disease (CAD) risk factors, prior CAD event history (MI or revascularization), angiographic findings (number diseased vessels...
Background— Electron-beam computed tomography (EBCT) is used to measure coronary calcification but not for aortic valve (AVC). Its accuracy, association with stenosis (AS) severity, and diagnostic prognostic value respect AVC are unknown. Methods Results— In 30 explanted valves, the score by EBCT (1125±1294 Agatston units [AU]) showed a strong linear correlation ( r =0.96, P <0.0001) valvular calcium weight (653±748 mg) pathology that allowed estimation of as score/1.7, small standard...
Tobacco and alcohol use are heritable behaviours associated with 15% 5.3% of worldwide deaths, respectively, due largely to broad increased risk for disease injury1-4. These substances used across the globe, yet genome-wide association studies have focused on individuals European ancestries5. Here we leveraged global genetic diversity 3.4 million from four major clines ancestry (approximately 21% non-European) power discovery fine-mapping genomic loci tobacco use, inform function these via...
Estimates from genome-wide association studies (GWAS) of unrelated individuals capture effects inherited variation (direct effects), demography (population stratification, assortative mating) and relatives (indirect genetic effects). Family-based GWAS designs can control for demographic indirect effects, but large-scale family datasets have been lacking. We combined data 178,086 siblings 19 cohorts to generate population (between-family) within-sibship (within-family) estimates 25...
Summary paragraph The Trans-Omics for Precision Medicine (TOPMed) program seeks to elucidate the genetic architecture and disease biology of heart, lung, blood, sleep disorders, with ultimate goal improving diagnosis, treatment, prevention. initial phases focus on whole genome sequencing individuals rich phenotypic data diverse backgrounds. Here, we describe TOPMed goals design as well resources early insights from sequence data. include a variant browser, genotype imputation panel, sharing...