Lawrence F. Bielak

ORCID: 0000-0002-3443-8030
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Research Areas
  • Genetic Associations and Epidemiology
  • Metabolomics and Mass Spectrometry Studies
  • Cardiac Imaging and Diagnostics
  • Epigenetics and DNA Methylation
  • Genetic and phenotypic traits in livestock
  • Genetic Mapping and Diversity in Plants and Animals
  • Liver Disease Diagnosis and Treatment
  • Nutrition, Genetics, and Disease
  • Cardiovascular Disease and Adiposity
  • Genomics and Rare Diseases
  • Bioinformatics and Genomic Networks
  • Birth, Development, and Health
  • RNA modifications and cancer
  • Cardiovascular Function and Risk Factors
  • Lipid metabolism and disorders
  • Lipid metabolism and biosynthesis
  • Lipoproteins and Cardiovascular Health
  • Cancer-related molecular mechanisms research
  • Pancreatic function and diabetes
  • Adipose Tissue and Metabolism
  • Atherosclerosis and Cardiovascular Diseases
  • Cardiovascular Health and Disease Prevention
  • Diet, Metabolism, and Disease
  • Diabetes, Cardiovascular Risks, and Lipoproteins
  • Alcohol Consumption and Health Effects

University of Michigan
2016-2025

Harvard University
2007-2023

Ferrer Grupo (Spain)
2020

Economic History Society
2020

Michigan United
2013-2019

Brigham and Women's Hospital
2017

Centre National de la Recherche Scientifique
2015

European Genomic Institute for Diabetes
2015

Authorised Association Consortium
2014

The University of Texas Health Science Center at Houston
2002-2013

Daniel Taliun Daniel Harris Michael D. Kessler Jedidiah Carlson Zachary A. Szpiech and 95 more Raúl Torres Sarah A. Gagliano Taliun André Corvelo Stephanie M. Gogarten Hyun Min Kang Achilleas Pitsillides Jonathon LeFaive Seung‐been Lee Xiaowen Tian Brian L. Browning Sayantan Das Anne‐Katrin Emde Wayne E. Clarke Douglas P. Loesch Amol C. Shetty Thomas W. Blackwell Albert V. Smith Quenna Wong Xiaoming Liu Matthew P. Conomos Dean Bobo François Aguet Christine M. Albert Álvaro Alonso Kristin Ardlie Dan E. Arking Stella Aslibekyan Paul L. Auer John Barnard R. Graham Barr Lucas Barwick Lewis C. Becker Rebecca Beer Emelia J. Benjamin Lawrence F. Bielak John Blangero Michael Boehnke Donald W. Bowden Jennifer A. Brody Esteban G. Burchard Brian E. Cade James F. Casella Brandon Chalazan Daniel I. Chasman Yii‐Der Ida Chen Michael H. Cho Seung Hoan Choi Mina K. Chung Clary B. Clish Adolfo Correa Joanne E. Curran Brian Custer Dawood Darbar Michelle Daya Mariza de Andrade Dawn L. DeMeo Susan K. Dutcher Patrick T. Ellinor Leslie Emery Celeste Eng Diane Fatkin Tasha E. Fingerlin Lukas Forer Myriam Fornage Nora Franceschini Christian Fuchsberger Stephanie M. Fullerton Søren Germer Mark T. Gladwin Daniel J. Gottlieb Xiuqing Guo Michael E. Hall Jiang He Nancy L. Heard‐Costa Susan R. Heckbert Marguerite R. Irvin Jill M. Johnsen Andrew D. Johnson Robert C. Kaplan Sharon L. R. Kardia Tanika N. Kelly Shannon Kelly Eimear E. Kenny Douglas P. Kiel Robert Klemmer Barbara A. Konkle Charles Kooperberg Anna Köttgen Leslie A. Lange Jessica Lasky‐Su Daniel Levy Xihong Lin Keng‐Han Lin Chunyu Liu Ruth J. F. Loos

Abstract The Trans-Omics for Precision Medicine (TOPMed) programme seeks to elucidate the genetic architecture and biology of heart, lung, blood sleep disorders, with ultimate goal improving diagnosis, treatment prevention these diseases. initial phases focused on whole-genome sequencing individuals rich phenotypic data diverse backgrounds. Here we describe TOPMed goals design as well available resources early insights obtained from sequence data. include a variant browser, genotype...

10.1038/s41586-021-03205-y article EN cc-by Nature 2021-02-10
Anubha Mahajan Daniel Taliun Matthias Thurner Neil R. Robertson Jason Torres and 95 more Nigel W. Rayner A. J. Payne Valgerður Steinthórsdóttir Robert A. Scott Niels Grarup James P. Cook Ellen M. Schmidt Matthias Wuttke Chloé Sarnowski Reedik Mägi Jana Nano Christian Gieger Stella Trompet Cécile Lecœur Michael Preuß Bram P. Prins Xiuqing Guo Lawrence F. Bielak Jennifer E. Below Donald W. Bowden John C. Chambers Young Jin Kim Maggie Ng Lauren E. Petty Xueling Sim Weihua Zhang Amanda J. Bennett Jette Bork‐Jensen Chad M. Brummett Mickaël Canouil Kai-Uwe Ec kardt Krista Fischer Sharon L. R. Kardia Florian Kronenberg Kristi Läll Yongmei Liu Adam E. Locke Jian’an Luan Ιωάννα Ντάλλα Vibe Nylander Sebastian Schönherr Claudia Schurmann Loïc Yengo Erwin P. Böttinger Ivan Brandslund Cramer Christensen George Dedoussis José C. Florez Ian Ford Oscar H. Franco Timothy M. Frayling Vilmantas Giedraitis Sophie Hackinger Andrew T. Hattersley Christian Herder M. Arfan Ikram Martin Ingelsson Marit E. Jørgensen Torben Jørgensen Jennifer Kriebel Johanna Kuusisto Symen Ligthart Cecilia M. Lindgren Allan Linneberg Valeriya Lyssenko Vasiliki Mamakou Thomas Meitinger Karen L. Mohlke Andrew D. Morris Girish N. Nadkarni James S. Pankow Annette Peters Naveed Sattar Alena Stančáková Konstantin Strauch Kent D. Taylor Barbara Thorand Guðmar Þorleifsson Unnur Þorsteinsdóttir Jaakko Tuomilehto Daniel R. Witte Josée Dupuis Patricia A. Peyser Eleftheria Zeggini Ruth J. F. Loos Philippe Froguel Erik Ingelsson Lars Lind Leif Groop Markku Laakso Francis S. Collins J. Wouter Jukema Colin N. A. Palmer Harald Grallert Andres Metspalu

10.1038/s41588-018-0241-6 article EN Nature Genetics 2018-10-01

Apolipoprotein C-III (apoC-III) inhibits triglyceride hydrolysis and has been implicated in coronary artery disease. Through a genome-wide association study, we have found that about 5% of the Lancaster Amish are heterozygous carriers null mutation (R19X) gene encoding apoC-III ( APOC3 ) and, as result, express half amount present noncarriers. Mutation compared with noncarriers had lower fasting postprandial serum triglycerides, higher levels HDL-cholesterol LDL-cholesterol. Subclinical...

10.1126/science.1161524 article EN Science 2008-12-12
Eirini Marouli Mariaelisa Graff Carolina Medina‐Gómez Ken Sin Lo Andrew R. Wood and 95 more Troels R. Kjær Rebecca S. Fine Yingchang Lu Claudia Schurmann Heather M. Highland Sina Rüeger Guðmar Þorleifsson Anne E. Justice David Lamparter Kathleen Stirrups Valérie Turcot Kristin L. Young Thomas W. Winkler Tõnu Esko Tugce Karaderi Adam E. Locke Nicholas G. D. Masca Maggie Ng Poorva Mudgal Manuel A. Rivas Sailaja Vedantam Anubha Mahajan Xiuqing Guo Gonçalo R. Abecasis Katja K.H. Aben Linda S. Adair Dewan S Alam Eva Albrecht Kristine H. Allin Matthew Allison Philippe Amouyel Emil V. R. Appel Dominique Arveiler Folkert W. Asselbergs Paul L. Auer Beverley Balkau Bernhard Banas Lia E. Bang Marianne Benn Sven Bergmann Lawrence F. Bielak Matthias Blüher Heiner Boeing Eric Boerwinkle Carsten A. Böger Lori L. Bonnycastle Jette Bork‐Jensen Michiel L. Bots Erwin P. Böttinger Donald W. Bowden Ivan Brandslund Gerome Breen Murray H. Brilliant Linda Broer Amber Burt Adam S. Butterworth David J. Carey Mark J. Caulfield John C. Chambers Daniel I. Chasman Yii‐Der Ida Chen Rajiv Chowdhury Cramer Christensen Audrey Y. Chu Massimiliano Cocca Francis S. Collins James P. Cook Janie Corley Jordi Corominas Galbany Amanda J. Cox Gabriel Cuéllar-Partida John Danesh Gail Davies Paul I. W. de Bakker Gert J. de Borst Simon de Denus Mark de Groot Renée de Mutsert Ian J. Deary George Dedoussis Ellen W. Demerath Anneke I. den Hollander Joe Dennis Emanuele Di Angelantonio Fotios Drenos Mengmeng Du Alison M. Dunning Douglas F. Easton Tapani Ebeling Todd L. Edwards Patrick T. Ellinor Paul Elliott Εvangelos Εvangelou Aliki‐Eleni Farmaki Jessica D. Faul

10.1038/nature21039 article EN Nature 2017-01-31
Alexander G. Bick Joshua S. Weinstock Satish K. Nandakumar Charles P. Fulco Erik L. Bao and 95 more Seyedeh M. Zekavat Mindy D Szeto Xiaotian Liao Matthew Leventhal Joseph Nasser Kyle Chang Cecelia Laurie Bala Bharathi Burugula Christopher J. Gibson Abhishek Niroula Amy Lin Margaret A. Taub François Aguet Kristin Ardlie Braxton D. Mitchell Kathleen C. Barnes Arden Moscati Myriam Fornage Susan Redline Bruce M. Psaty Edwin K. Silverman Scott T. Weiss Colin N. A. Palmer Ramachandran S. Vasan Esteban G. Burchard Sharon L. R. Kardia Jiang He Robert C. Kaplan Nicholas L. Smith Donna K. Arnett David A. Schwartz Adolfo Correa Mariza de Andrade Xiuqing Guo Barbara A. Konkle Brian Custer Juan M. Peralta Hongsheng Gui Deborah A. Meyers Stephen T. McGarvey Ida Yii-Der Chen M. Benjamin Shoemaker Patricia A. Peyser Jai Broome Stephanie M. Gogarten Fei Fei Wang Quenna Wong May E. Montasser Michelle Daya Eimear E. Kenny Kari E. North Lenore J. Launer Brian E. Cade Joshua C. Bis Michael H. Cho Jessica Lasky‐Su Donald W. Bowden L. Adrienne Cupples Angel C. Y. Mak Lewis C. Becker Jennifer A. Smith Tanika N. Kelly Stella Aslibekyan Susan R. Heckbert H.K. Tiwari Ivana V. Yang John A. Heit Steven A. Lubitz Jill M. Johnsen Joanne E. Curran Sally E. Wenzel Daniel E. Weeks D. C. Rao Dawood Darbar Jee‐Young Moon Russell P. Tracy Erin Buth Nicholas Rafaels Ruth J. F. Loos Peter Durda Yongmei Liu Lifang Hou Jiwon Lee Priyadarshini Kachroo Barry I. Freedman Daniel Levy Lawrence F. Bielak James E. Hixson James S. Floyd Eric A. Whitsel Patrick T. Ellinor Marguerite R. Irvin Tasha E. Fingerlin Laura M. Raffield Sebastian M. Armasu

10.1038/s41586-020-2819-2 article EN Nature 2020-10-14
Jihua Chen Cassandra N. Spracklen Gaëlle Marenne Arushi Varshney Laura J. Corbin and 95 more Jian’an Luan Sara M. Willems Ying Wu Xiaoshuai Zhang Momoko Horikoshi Thibaud Boutin Reedik Mägi Johannes Waage Ruifang Li‐Gao Kei Hang Katie Chan Jie Yao Mila Desi Anasanti Audrey Y. Chu Annique Claringbould Jani Heikkinen Jaeyoung Hong Jouke‐Jan Hottenga Shaofeng Huo Marika Kaakinen Tin Louie Winfried März Hortensia Moreno-Macías Anne Ndungu Sarah C. Nelson Ilja M. Nolte Kari E. North Chelsea K. Raulerson Debashree Ray Rebecca Rohde Denis Rybin Claudia Schurmann Xueling Sim Lorraine Southam Isobel D. Stewart Carol A. Wang Yujie Wang Peitao Wu Weihua Zhang Tarunveer S. Ahluwalia Emil V. R. Appel Lawrence F. Bielak Jennifer A. Brody Noël P. Burtt Claudia Cabrera Brian E. Cade Jin Fang Chai Xiaoran Chai Li-Ching Chang Chien-Hsiun Chen Brian H. Chen Kumaraswamy Naidu Chitrala Yen‐Feng Chiu Hugoline G. de Haan Graciela E. Delgado Ayşe Demirkan Qing Duan Jorgen Engmann Segun Fatumo Javier Gayán Franco Giulianini Jung Ho Gong Stefan Gustafsson Yang Hai Fernando Pires Hartwig Jing He Yoriko Heianza Tao Huang Alicia Huerta-Chagoya Mi Yeong Hwang Richard A. Jensen Takahisa Kawaguchi Katherine A. Kentistou Young Jin Kim Marcus E. Kleber Ishminder K. Kooner Shuiqing Lai Leslie A. Lange Carl D. Langefeld Marie Lauzon Man Li Symen Ligthart Jun Liu Marie Loh Jirong Long Valeriya Lyssenko Massimo Mangino Carola Marzi May E. Montasser Abhishek Nag Masahiro Nakatochi Damia Noce Raymond Noordam Giorgio Pistis Michael Preuß Laura M. Raffield

10.1038/s41588-021-00852-9 article EN Nature Genetics 2021-05-31
Loïc Yengo Sailaja Vedantam Eirini Marouli Julia Sidorenko Eric Bartell and 95 more Saori Sakaue Marielisa Graff Anders U. Eliasen Yunxuan Jiang Sridharan Raghavan Jenkai Miao Joshua Arias Sarah E. Graham Ronen E. Mukamel Cassandra N. Spracklen Xianyong Yin Shyh‐Huei Chen Teresa Ferreira Heather H Highland Yingjie Ji Tugce Karaderi Kuang Lin Kreete Lüll Deborah E. Malden Carolina Medina‐Gómez Moara Machado Amy Moore Sina Rüeger Xueling Sim Scott Vrieze Tarunveer S. Ahluwalia Masato Akiyama Matthew Allison Marcus Alvarez Mette K. Andersen Alireza Ani Vivek Appadurai Liubov Arbeeva Seema Bhaskar Lawrence F. Bielak Sailalitha Bollepalli Lori L. Bonnycastle Jette Bork‐Jensen Jonathan P. Bradfield Yuki Bradford Peter S. Braund Jennifer A. Brody Kristoffer Sølvsten Burgdorf Brian E. Cade Hui Cai Qiuyin Cai Archie Campbell Marisa Cañadas‐Garre Eulalia Catamo Jin Fang Chai Xiaoran Chai Li-Ching Chang Yi–Cheng Chang Chien-Hsiun Chen Alessandra Chesi Seung Hoan Choi Ren‐Hua Chung Massimiliano Cocca Maria Pina Concas Christian Couture Gabriel Cuéllar-Partida Rebecca Danning E. Warwick Daw Frauke Degenhard Graciela E. Delgado Alessandro Delitala Ayşe Demirkan Xuan Deng Poornima Devineni Alexander Dietl Maria Dimitriou Latchezar Dimitrov Rajkumar Dorajoo Arif B. Ekici Jorgen Engmann Zammy Fairhurst-Hunter Aliki‐Eleni Farmaki Jessica D. Faul Juan-Carlos Fernandez-Lopez Lukas Forer Margherita Francescatto Sandra Freitag‐Wolf Christian Fuchsberger Tessel E. Galesloot Yan Gao Zishan Gao Frank Geller Olga Giannakopoulou Franco Giulianini Anette P. Gjesing Anuj Goel Scott D. Gordon Mathias Gorski Jakob Grove Xiuqing Guo

Common single-nucleotide polymorphisms (SNPs) are predicted to collectively explain 40-50% of phenotypic variation in human height, but identifying the specific variants and associated regions requires huge sample sizes

10.1038/s41586-022-05275-y article EN cc-by Nature 2022-10-12

Background Electron-beam CT (EBCT) quantification of coronary artery calcification (CAC) allows noninvasive assessment atherosclerosis. We undertook a follow-up study to determine whether CAC extent, measured at the time angiography by EBCT, predicted future hard cardiac events, comprising death and nonfatal myocardial infarction (MI). also assessed potential selected disease (CAD) risk factors, prior CAD event history (MI or revascularization), angiographic findings (number diseased vessels...

10.1161/hc2901.093112 article EN Circulation 2001-07-24

Background— Electron-beam computed tomography (EBCT) is used to measure coronary calcification but not for aortic valve (AVC). Its accuracy, association with stenosis (AS) severity, and diagnostic prognostic value respect AVC are unknown. Methods Results— In 30 explanted valves, the score by EBCT (1125±1294 Agatston units [AU]) showed a strong linear correlation ( r =0.96, P <0.0001) valvular calcium weight (653±748 mg) pathology that allowed estimation of as score/1.7, small standard...

10.1161/01.cir.0000135469.82545.d0 article EN Circulation 2004-07-13
Valérie Turcot Yingchang Lu Heather M. Highland Claudia Schurmann Anne E. Justice and 95 more Rebecca S. Fine Jonathan P. Bradfield Tõnu Esko Ayush Giri Mariaelisa Graff Xiuqing Guo Audrey E. Hendricks Tugce Karaderi Adelheid Lempradl Adam E. Locke Anubha Mahajan Eirini Marouli Suthesh Sivapalaratnam Kristin L. Young Tamuno Alfred Mary F. Feitosa Nicholas G. D. Masca Alisa K. Manning Carolina Medina‐Gómez Poorva Mudgal Maggie C. Y. Ng Alex P. Reiner Sailaja Vedantam Sara M. Willems Thomas W. Winkler Gonçalo R. Abecasis Katja K.H. Aben Dewan S Alam Sameer Alharthi Matthew Allison Philippe Amouyel Folkert W. Asselbergs Paul L. Auer Beverley Balkau Lia E. Bang Inês Barroso Lisa Bastarache Marianne Benn Sven Bergmann Lawrence F. Bielak Matthias Blüher Michael Boehnke Heiner Boeing Eric Boerwinkle Carsten A. Böger Jette Bork‐Jensen Michiel L. Bots Erwin P. Böttinger Donald W. Bowden Ivan Brandslund Gerome Breen Murray H. Brilliant Linda Broer Marco Brumat Amber Burt Adam S. Butterworth Peter T. Campbell Stefania Cappellani David J. Carey Eulalia Catamo Mark J. Caulfield John C. Chambers Daniel I. Chasman Yii‐Der Ida Chen Rajiv Chowdhury Cramer Christensen Audrey Y. Chu Massimiliano Cocca Francis S. Collins James P. Cook Janie Corley Jordi Corominas Galbany Amanda J. Cox David S. Crosslin Gabriel Cuéllar-Partida Angela D’Eustacchio John Danesh Gail Davies Paul I. W. de Bakker Mark de Groot Renée de Mutsert Ian J. Deary George Dedoussis Ellen W. Demerath Martin den Heijer Anneke I. den Hollander Hester M. den Ruijter Joe Dennis Joshua C. Denny Emanuele Di Angelantonio Fotios Drenos Mengmeng Du Marie‐Pierre Dubé Alison M. Dunning Douglas F. Easton

10.1038/s41588-017-0011-x article EN Nature Genetics 2017-12-19
Nicola Barban Rick Jansen Ronald de Vlaming Ahmad Vaez Jornt J. Mandemakers and 95 more Felix C. Tropf Xia Shen James F. Wilson Daniel I. Chasman Ilja M. Nolte Vinicius Tragante Sander W. van der Laan John R. B. Perry Augustine Kong Tarunveer S. Ahluwalia Eva Albrecht Laura M. Yerges-Armstrong Gil Atzmon Kirsi Auro Kristin L. Ayers Andrew Bakshi Danny Ben‐Avraham Kenneth I. Berger Aviv Bergman Lars Bertram Lawrence F. Bielak Gyða Björnsdóttir Marc Jan Bonder Linda Broer Minh Bui Caterina Barbieri Alana Cavadino Jorge E. Chavarro Constance Turman Maria Pina Concas Heather J. Cordell Gail Davies Peter Eibich Nicholas Eriksson Tõnu Esko Joel Eriksson Fahimeh Falahi Janine F. Felix Mark Alan Fontana Lude Franke Ilaria Gandin Audrey J. Gaskins Christian Gieger Erica P. Gunderson Xiuqing Guo Caroline Hayward Chunyan He Edith Hofer Hongyan Huang Peter K. Joshi Stavroula Kanoni Robert Karlsson Stefan Kiechl Annette Kifley Alexander Kluttig Peter Kraft Vasiliki Lagou Cécile Lecœur Jari Lahti Ruifang Li‐Gao Penelope A. Lind Tian Liu Enes Makalic Crysovalanto Mamasoula Lindsay Matteson Hamdi Mbarek Patrick F. McArdle George McMahon S. Fleur W. Meddens Evelin Mihailov Mike Miller Stacey A. Missmer Claire Monnereau Peter J. van der Most Ronny Myhre Mike A. Nalls Teresa Nutile Ioanna Panagiota Kalafati Eleonora Porcu Inga Prokopenko Kumar B. Rajan Janet W. Rich‐Edwards Cornelius A. Rietveld Antonietta Robino Lynda M. Rose Rico Rueedi Kathleen A. Ryan Yasaman Saba Daniel Schmidt Jennifer A. Smith Lisette Stolk Elizabeth A. Streeten Anke Tönjes Guðmar Þorleifsson Sheila Ulivi

10.1038/ng.3698 article EN Nature Genetics 2016-10-31
Gretchen Saunders Xingyan Wang Fang Chen Seon-Kyeong Jang Mengzhen Liu and 95 more Chen Wang Shuang Gao Yu Jiang Chachrit Khunsriraksakul Jacqueline M. Otto Clifton Addison Masato Akiyama Christine M. Albert Fazil Alıev Álvaro Alonso Donna K. Arnett Allison E. Ashley‐Koch Aneel A. Ashrani Kathleen C. Barnes R. Graham Barr Traci M. Bartz Diane M. Becker Lawrence F. Bielak Emelia J. Benjamin Joshua C. Bis Gyða Björnsdóttir John Blangero Eugene R. Bleecker Jason D. Boardman Eric Boerwinkle Dorret I. Boomsma Meher P. Boorgula Donald W. Bowden Jennifer A. Brody Brian E. Cade Daniel I. Chasman Sameer Chavan Yii‐Der Ida Chen Zhengming Chen Iona Cheng Michael H. Cho Hélène Choquet John W. Cole Marilyn C. Cornelis Francesco Cucca Joanne E. Curran Mariza de Andrade Danielle M. Dick Anna R. Docherty Ravindranath Duggirala Charles B. Eaton Marissa A. Ehringer Tõnu Esko Jessica D. Faul Lilian Fernandes Silva Edoardo Fiorillo Myriam Fornage Barry I. Freedman Maiken E. Gabrielsen Melanie E. Garrett Sina A. Gharib Christian Gieger Nathan A. Gillespie David C. Glahn Scott D. Gordon C. Charles Gu Dongfeng Gu Daníel F. Guðbjartsson Xiuqing Guo Jeffrey Haessler Michael E. Hall Toomas Haller Kathleen Mullan Harris Jiang He Pamela Herd John K. Hewitt Ian B. Hickie Bertha Hidalgo John E. Hokanson Christian J. Hopfer Jouke‐Jan Hottenga Lifang Hou Hongyan Huang Yi‐Jen Hung David J. Hunter Kristian Hveem Shih‐Jen Hwang Chii‐Min Hwu William G. Iacono Marguerite R. Irvin Yon Ho Jee Eric O. Johnson Yoonjung Yoonie Joo Eric Jorgenson Anne E. Justice Yoichiro Kamatani Robert C. Kaplan Jaakko Kaprio Sharon L. R. Kardia Matthew C. Keller

Tobacco and alcohol use are heritable behaviours associated with 15% 5.3% of worldwide deaths, respectively, due largely to broad increased risk for disease injury1-4. These substances used across the globe, yet genome-wide association studies have focused on individuals European ancestries5. Here we leveraged global genetic diversity 3.4 million from four major clines ancestry (approximately 21% non-European) power discovery fine-mapping genomic loci tobacco use, inform function these via...

10.1038/s41586-022-05477-4 article EN cc-by Nature 2022-12-07
Laurence J Howe Michel G. Nivard Tim Morris Ailin Falkmo Hansen Humaira Rasheed and 95 more Yoonsu Cho Geetha Chittoor Rafael Ahlskog Penelope A. Lind Teemu Palviainen Matthijs D. van der Zee Rosa Cheesman Massimo Mangino Yunzhang Wang Shuai Li Lucija Klarić Scott M. Ratliff Lawrence F. Bielak Marianne Nygaard Alexandros Giannelis Emily A. Willoughby Chandra A. Reynolds Jared V. Balbona Ole A. Andreassen Helga Ask Aris Baras Christopher R. Bauer Dorret I. Boomsma Archie Campbell Harry Campbell Zhengming Chen Paraskevi Christofidou Elizabeth C. Corfield Christina C. Dahm Deepika Dokuru Luke M. Evans Eco J. C. de Geus Sudheer Giddaluru Scott D. Gordon K. Paige Harden W. David Hill Amanda Hughes Shona M. Kerr Yongkang Kim Hyeokmoon Kweon Antti Latvala Debbie A. Lawlor Liming Li Kuang Lin Per Magnus Patrik K. E. Magnusson Travis T. Mallard Pekka Martikainen Melinda Mills Pål R. Njølstad John D. Overton Nancy L. Pedersen David J. Porteous Jeffrey G. Reid Karri Silventoinen Melissa C. Southey Camilla Stoltenberg Elliot M. Tucker‐Drob Margaret J. Wright Hyeokmoon Kweon Philipp Koellinger Daniel J. Benjamin Patrick Turley Laurence J Howe Michel G. Nivard Tim Morris Ailin Falkmo Hansen Humaira Rasheed Yoonsu Cho Geetha Chittoor Rafael Ahlskog Penelope A. Lind Teemu Palviainen Matthijs D. van der Zee Rosa Cheesman Massimo Mangino Yunzhang Wang Shuai Li Lucija Klarić Scott M. Ratliff Lawrence F. Bielak Marianne Nygaard Alexandros Giannelis Emily A. Willoughby Chandra A. Reynolds Jared V. Balbona Ole A. Andreassen Helga Ask Dorret I. Boomsma Archie Campbell Harry Campbell Zhengming Chen Paraskevi Christofidou Elizabeth C. Corfield Christina C. Dahm

Estimates from genome-wide association studies (GWAS) of unrelated individuals capture effects inherited variation (direct effects), demography (population stratification, assortative mating) and relatives (indirect genetic effects). Family-based GWAS designs can control for demographic indirect effects, but large-scale family datasets have been lacking. We combined data 178,086 siblings 19 cohorts to generate population (between-family) within-sibship (within-family) estimates 25...

10.1038/s41588-022-01062-7 article EN cc-by Nature Genetics 2022-05-01
Daniel Taliun Daniel Harris Michael D. Kessler Jedidiah Carlson Zachary A. Szpiech and 95 more Raúl Torres Sarah A. Gagliano Taliun André Corvelo Stephanie M. Gogarten Hyun Min Kang Achilleas Pitsillides Jonathon LeFaive Seung‐been Lee Xiaowen Tian Brian L. Browning Sayantan Das Anne‐Katrin Emde Wayne E. Clarke Douglas P. Loesch Amol C. Shetty Thomas W. Blackwell Quenna Wong François Aguet Christine M. Albert Álvaro Alonso Kristin Ardlie Stella Aslibekyan Paul L. Auer John Barnard R. Graham Barr Lewis C. Becker Rebecca Beer Emelia J. Benjamin Lawrence F. Bielak John Blangero Michael Boehnke Donald W. Bowden Jennifer A. Brody Esteban G. Burchard Brian E. Cade James F. Casella Brandon Chalazan Yii‐Der Ida Chen Michael H. Cho Seung Hoan Choi Mina K. Chung Clary B. Clish Adolfo Correa Joanne E. Curran Brian Custer Dawood Darbar Michelle Daya Mariza de Andrade Dawn L. DeMeo Susan K. Dutcher Patrick T. Ellinor Leslie Emery Diane Fatkin Lukas Forer Myriam Fornage Nora Franceschini Christian Fuchsberger Stephanie M. Fullerton Søren Germer Mark T. Gladwin Daniel J. Gottlieb Xiuqing Guo Michael E. Hall Jiang He Nancy L. Heard‐Costa Susan R. Heckbert Marguerite R. Irvin Jill M. Johnsen Andrew D. Johnson Sharon L. R. Kardia Tanika N. Kelly Shannon Kelly Eimear E. Kenny Douglas P. Kiel Robert Klemmer Barbara A. Konkle Charles Kooperberg Anna Köttgen Leslie A. Lange Jessica Lasky‐Su Daniel Levy Xihong Lin Keng‐Han Lin Chunyu Liu Ruth J. F. Loos Lori Garman Robert E. Gerszten Steven A. Lubitz Kathryn L. Lunetta Angel C. Y. Mak Ani Manichaikul Alisa K. Manning Rasika A. Mathias David D. McManus Stephen T. McGarvey

Summary paragraph The Trans-Omics for Precision Medicine (TOPMed) program seeks to elucidate the genetic architecture and disease biology of heart, lung, blood, sleep disorders, with ultimate goal improving diagnosis, treatment, prevention. initial phases focus on whole genome sequencing individuals rich phenotypic data diverse backgrounds. Here, we describe TOPMed goals design as well resources early insights from sequence data. include a variant browser, genotype imputation panel, sharing...

10.1101/563866 preprint EN cc-by bioRxiv (Cold Spring Harbor Laboratory) 2019-03-06
Xihao Li Zilin Li Hufeng Zhou Sheila M. Gaynor Yaowu Liu and 95 more Han Chen Ryan Sun Rounak Dey Donna K. Arnett Stella Aslibekyan Christie M. Ballantyne Lawrence F. Bielak John Blangero Eric Boerwinkle Donald W. Bowden Jai Broome Matthew P. Conomos Adolfo Correa L. Adrienne Cupples Joanne E. Curran Barry I. Freedman Xiuqing Guo George Hindy Marguerite R. Irvin Sharon L. R. Kardia Sekar Kathiresan Alyna Khan Charles Kooperberg Cathy C. Laurie X. Shirley Liu Michael C. Mahaney Ani Manichaikul Lisa W. Martin Rasika A. Mathias Stephen T. McGarvey Braxton D. Mitchell May E. Montasser Jill E. Moore Alanna C. Morrison Jeffrey R. O’Connell Colin N. A. Palmer Akhil Pampana Juan M. Peralta Patricia A. Peyser Bruce M. Psaty Susan Redline Kenneth Rice Stephen S. Rich Jennifer A. Smith Hemant K. Tiwari Michael Y. Tsai Ramachandran S. Vasan Fei Fei Wang Daniel E. Weeks Zhiping Weng James G. Wilson Lisa R. Yanek Namiko Abe Gonçalo R. Abecasis François Aguet Christine M. Albert Laura Almasy Álvaro Alonso Seth A. Ament Peter Anderson Pramod Anugu Deborah Applebaum‐Bowden Kristin Ardlie Dan Arking Donna K. Arnett Allison E. Ashley‐Koch Stella Aslibekyan Tim Assimes Paul L. Auer Dimitrios Avramopoulos John Barnard Kathleen C. Barnes R. Graham Barr Emily Barron‐Casella Lucas Barwick Terri Beaty Gerald J. Beck Diane M. Becker Lewis C. Becker Rebecca Beer Amber L. Beitelshees Emelia J. Benjamin Takis Benos Marcos Bezerra Lawrence F. Bielak Joshua C. Bis Thomas W. Blackwell John Blangero Eric Boerwinkle Donald W. Bowden Russell P. Bowler Jennifer A. Brody Ulrich Broeckel Jai Broome Karen Bunting

10.1038/s41588-020-0676-4 article EN Nature Genetics 2020-08-24
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