A5026784962- Child and Adolescent Psychosocial and Emotional Development
- Maternal Mental Health During Pregnancy and Postpartum
- Genetic Associations and Epidemiology
- COVID-19 and Mental Health
- Birth, Development, and Health
- Genetics and Neurodevelopmental Disorders
- Autism Spectrum Disorder Research
- Attention Deficit Hyperactivity Disorder
- Health disparities and outcomes
- Cognitive Abilities and Testing
- Obesity, Physical Activity, Diet
- Health, Environment, Cognitive Aging
- Child Nutrition and Feeding Issues
- Nutrition, Genetics, and Disease
- Eating Disorders and Behaviors
- Family Caregiving in Mental Illness
- Long-Term Effects of COVID-19
- Family Support in Illness
- Adolescent and Pediatric Healthcare
- Infant Development and Preterm Care
- Child Abuse and Trauma
- Youth Substance Use and School Attendance
- Prenatal Substance Exposure Effects
- Intergenerational Family Dynamics and Caregiving
- Family and Patient Care in Intensive Care Units
University of Oslo
2015-2025
Norwegian Institute of Public Health
2015-2025
Lovisenberg Diakonale Høgskole
2023
University College London
2023
Oslo University Hospital
2022-2023
Diacon (Canada)
2023
VID Specialized University
2022
University of Edinburgh
2022
Zealand University Hospital
2022
Faculty of Public Health
2022
Estimates from genome-wide association studies (GWAS) of unrelated individuals capture effects inherited variation (direct effects), demography (population stratification, assortative mating) and relatives (indirect genetic effects). Family-based GWAS designs can control for demographic indirect effects, but large-scale family datasets have been lacking. We combined data 178,086 siblings 19 cohorts to generate population (between-family) within-sibship (within-family) estimates 25...
<h2>Summary</h2><h3>Background</h3> Long-term mental and physical health consequences of COVID-19 (long COVID) are a persistent public concern. Little is still known about the long-term non-hospitalised patients with varying illness severities. Our aim was to assess prevalence adverse symptoms among individuals diagnosed in general population by acute infection severity up 16 months after diagnosis. <h3>Methods</h3> This observational follow-up study included seven prospectively planned...
Abstract Urban-living individuals are exposed to many environmental factors that may combine and interact influence mental health. While individual of an urban environment have been investigated in isolation, no attempt has made model how complex, real-life exposure living the city relates brain health, this is moderated by genetic factors. Using data 156,075 participants from UK Biobank, we carried out sparse canonical correlation analyses investigate relationships between environments...
The relationship between alcohol consumption and dementia risk is unclear. This investigation estimates the association reported in a population-based study mid-1980s for up to 27 years later. entire adult population one Norwegian county was invited Nord-Trøndelag Health Study during 1984-1986 (HUNT1): 88 % participated. sample used this includes HUNT1 participants born 1905 1946 who completed questionnaire assessing consumption. A total of 40,435 individuals, whom 1084 have developed...
Background Low educational attainment in parents is associated with child psychopathology. It not clear whether the associations are due to risk factors that family members share or effects of maternal paternal education on offspring. We investigate between and symptoms attention deficit/hyperactivity disorder (ADHD), depression, academic problems shared genetic factors, environmental parental phenotype itself. Methods This study based Norwegian Mother, Father Child Cohort Study (MoBa). The...
Abstract Background The Norwegian Mother, Father, and Child Cohort Study (MoBa) is a population-based pregnancy cohort, which includes approximately 114,500 children, 95,200 mothers, 75,200 fathers. Genotyping of MoBa has been conducted through multiple research projects, spanning several years; using varying selection criteria, genotyping arrays, centres. contains numerous interrelated families, necessitated the implementation family-based quality control (QC) pipeline that verifies...
Several maternal exposures during pregnancy are considered predisposing factors for offspring neurodevelopmental conditions. However, many of these may be noncausal and biased by genetic liability.
Although the persistence of physical symptoms after SARS-CoV-2 infection is a major public health concern, evidence from large observational studies beyond one year post diagnosis remain scarce. We aimed to assess prevalence in relation acute illness severity up more than 2-years COVID-19.This multinational study included 64,880 adult participants Iceland, Sweden, Denmark, and Norway with self-reported data on COVID-19 April 2020 August 2022. compared 15 symptoms, measured by Patient Health...
Technological devices play a central role in adolescents life. Despite concerns about negative effects of excessive screen time on mental health and development, there is little knowledge fundamental features behaviours underlying genetic architecture. Using self reports from (14-16 years old) the Norwegian Mother, Father, Child Cohort Study (MoBa, n = 18 490), we performed genome-wide association analysis for four behaviors: spent 1) watching movies/series/TV; 2) gaming; 3) sitting/lying...
Early in life, behavioral and cognitive traits associated with risk for developing a psychiatric condition are broad undifferentiated. As children develop, these differentiate into characteristic clusters of symptoms behaviors that ultimately form the basis diagnostic categories. Understanding this differentiation process - context genetic conditions, which is highly generalized can improve early detection intervention. We modeled emotional problems from age 1.5-5 years (behavioral = score)...
Preterm birth is associated with an increased risk of attention-deficit/hyperactivity disorder (ADHD); however, it unclear to what extent this association can be explained by shared genetic and environmental factors whether gestational age at similarly related inattention hyperactivity/impulsivity the same in boys girls.
Abstract Identifying mechanisms underlying the intergenerational transmission of risk for attention-deficit/hyperactivity disorder (ADHD) traits can inform interventions and provide insights into role parents in shaping their children’s outcomes. We investigated whether genetic nurture (environmentally mediated effects) underlie associations between polygenic scores indexing parental protective factors offspring’s ADHD traits. This birth cohort study included 19,506 genotyped...
The aetiology of conduct problems involves a combination genetic and environmental factors, many which are inherently linked to parental characteristics given parents' central role in children's lives across development. It is important disentangle what extent links between heritable behaviour due transmission risk or indirect influences via the environment (i.e., nurture). We used 31,290 genotyped mother-father-child trios from Norwegian Mother, Father Child Cohort Study (MoBa), testing...
Abstract Background The timing of puberty may have an important impact on adolescent mental health. In particular, earlier age at menarche has been associated with elevated rates depression in adolescents. Previous research suggests that this relationship be causal, but replication and investigation whether effect extends to other health domains is warranted. Methods Registered Report, we triangulated evidence from different causal inference methods using a new wave data ( N = 13,398) the...
Abstract The major anxiety disorders (ANX; including generalized disorder, panic and phobias ) are highly prevalent, often onset early, persist throughout life, cause substantial global disability. Although distinct in their clinical presentations, they likely represent differential expressions of a dysregulated threat-response system. Here we present genome-wide association meta-analysis comprising 122,341 European ancestry ANX cases 729,881 controls. We identified 58 independent...
This study investigates the relationship between parental drinking and school adjustment in a total population sample of adolescents, with independent reports from mothers, fathers, adolescents. As group, children alcohol abusers have previously been found to exhibit lowered academic achievement. However, few studies address which parts that may be impaired. Both genetic approach social strains predict elevated problem scores these children. Previous research has had limitations such as only...
Maternal fever during pregnancy is associated with several adverse child outcomes. We investigated associations between maternal and ADHD among offspring, as well the sub-dimensions of - inattention hyperactivity/impulsivity. Data came from Norwegian Mother Child Cohort Study, including more than 114,000 children. Information about children's diagnoses was obtained Patient Register. Mothers reported on hyperactivity/impulsivity symptoms in questionnaires at 8 years. Logistic regression...