A5017312170- Stress Responses and Cortisol
- Birth, Development, and Health
- Epigenetics and DNA Methylation
- Tryptophan and brain disorders
- Genetic Associations and Epidemiology
- Hormonal Regulation and Hypertension
- Child and Adolescent Psychosocial and Emotional Development
- Neuroendocrine regulation and behavior
- Mental Health Research Topics
- Neonatal Respiratory Health Research
- Genetics and Neurodevelopmental Disorders
- Maternal Mental Health During Pregnancy and Postpartum
- Bipolar Disorder and Treatment
- Treatment of Major Depression
- Functional Brain Connectivity Studies
- Cognitive Abilities and Testing
- Childhood Cancer Survivors' Quality of Life
- Adolescent and Pediatric Healthcare
- Child Abuse and Trauma
- Pregnancy and preeclampsia studies
- Early Childhood Education and Development
- Health, Environment, Cognitive Aging
- Resilience and Mental Health
- Identity, Memory, and Therapy
- Receptor Mechanisms and Signaling
Max Planck Institute of Psychiatry
2016-2025
Emory University
2016-2025
VA Connecticut Healthcare System
2017-2024
Yale University
2017-2024
Universität Innsbruck
2015-2024
California Department of Education
2023-2024
Technical University of Munich
2021-2024
Innsbruck Medical University
2009-2024
LMU Klinikum
2024
Ludwig-Maximilians-Universität München
2009-2024
<h3>Context</h3>In addition to trauma exposure, other factors contribute risk for development of posttraumatic stress disorder (PTSD) in adulthood. Both genetic and environmental are contributory, with child abuse providing significant liability.<h3>Objective</h3>To increase understanding as well their interaction the PTSD by gene × environment interactions abuse, level non–child polymorphisms at stress-related FKBP5.<h3>Design, Setting, Participants</h3>A cross-sectional study examining...
<h3>Context</h3> Genetic inheritance and developmental life stress both contribute to major depressive disorder in adults. Child abuse trauma alter the endogenous response, principally corticotropin-releasing hormone its downstream effectors, suggesting that a gene × environment interaction at this locus may be important depression. <h3>Objective</h3> To examine whether effects of child on adult symptoms are moderated by genetic polymorphisms within type 1 receptor (<i>CRHR1</i>) gene....
Childhood maltreatment is likely to influence fundamental biological processes and engrave long-lasting epigenetic marks, leading adverse health outcomes in adulthood. We aimed elucidate the impact of different early environment on disease-related genome-wide gene expression DNA methylation peripheral blood cells patients with posttraumatic stress disorder (PTSD). Compared same trauma-exposed controls (n = 108), gene-expression profiles PTSD similar clinical symptoms matched adult trauma...
Chronic psychological stress is associated with accelerated aging and increased risk for aging-related diseases, but the underlying molecular mechanisms are unclear. We examined effect of lifetime stressors on a DNA methylation-based age predictor, epigenetic clock. After controlling blood cell-type composition lifestyle parameters, cumulative stress, not childhood maltreatment or current alone, predicted in an urban, African American cohort (n = 392). This was primarily driven by personal...
Insulin pump therapy may improve metabolic control in young patients with type 1 diabetes, but the association short-term diabetes complications is unclear.To determine whether rates of severe hypoglycemia and diabetic ketoacidosis are lower insulin compared injection children, adolescents, adults diabetes.Population-based cohort study conducted between January 2011 December 2015 446 centers participating Diabetes Prospective Follow-up Initiative Germany, Austria, Luxembourg. Patients...
Highlights•m6A/m mRNA methylation in the adult mouse brain is regulated by stress•m6A/m regulation region, time, and gene specific•Mettl3 Fto cKO alter m6A/m, fear memory, expression, synaptic plasticity•The m6A/m glucocorticoid response impaired major depressive disorder patientsSummaryN6-methyladenosine (m6A) N6,2′-O-dimethyladenosine (m6Am) are abundant modifications that regulate transcript processing translation. The role of both, here termed stress vivo currently unknown. Here, we...
Abstract Background Gene expression profiling from peripheral blood is a valuable tool for biomarker discovery in clinical studies. Different whole RNA collection and processing methods are highly variable might confound comparisons of results across The main aim the study was to compare genome-wide gene profiles obtained two widely used commercially available systems - PAXgene™ Tempus™ tubes. Comparisons present call rates, variances, correlations influence globin reduction performed using...