A5024685042- Stress Responses and Cortisol
- Birth, Development, and Health
- Epigenetics and DNA Methylation
- Intergenerational Family Dynamics and Caregiving
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Child and Adolescent Psychosocial and Emotional Development
- Tryptophan and brain disorders
- Genetics and Neurodevelopmental Disorders
- Quantum optics and atomic interactions
- Neurogenetic and Muscular Disorders Research
- Adolescent Sexual and Reproductive Health
- Peptidase Inhibition and Analysis
- Family Caregiving in Mental Illness
- Spectroscopy and Quantum Chemical Studies
- Proteoglycans and glycosaminoglycans research
- Photochemistry and Electron Transfer Studies
- Wnt/β-catenin signaling in development and cancer
- Mental Health and Psychiatry
- Organic Electronics and Photovoltaics
- Electrochemical Analysis and Applications
- Genetics, Aging, and Longevity in Model Organisms
- Organometallic Compounds Synthesis and Characterization
- Art Therapy and Mental Health
- Neuroendocrine regulation and behavior
- Glass properties and applications
UCLA Health
2023
Max Planck Institute of Psychiatry
2015-2022
Lock Haven University
2018
Philipps University of Marburg
1982-2009
Columbia College
2003
Women's College Hospital
2003
Columbia University
2003
Health Sciences Centre
2003
Boston University
2003
Sunnybrook Health Science Centre
2003
Chronic psychological stress is associated with accelerated aging and increased risk for aging-related diseases, but the underlying molecular mechanisms are unclear. We examined effect of lifetime stressors on a DNA methylation-based age predictor, epigenetic clock. After controlling blood cell-type composition lifestyle parameters, cumulative stress, not childhood maltreatment or current alone, predicted in an urban, African American cohort (n = 392). This was primarily driven by personal...
Theoretical models of persecutory delusions have emphasized the impact reasoning biases and negative emotion at early stages symptom formation. However, causal mechanisms remain unclear. This study tests hypothesis that state anxiety will increase paranoid ideation this be moderated by level individual vulnerability mediated tendency to jump conclusions. Healthy participants (n = 90) with varying levels (psychosis symptoms assessed Community Assessment Psychic Experiences) were randomly...
Panic disorder (PD) affects about four million Europeans, with women affected twice as likely men, causing substantial suffering and high economic costs. The etiopathogenesis of PD remains largely unknown, but both genetic environmental factors contribute to risk. An epigenome-wide association study (EWAS) was conducted compare medication-free patients (n = 89) healthy controls 76) stratified by gender. Replication sought in an independent sample (131 cases, 169 controls) functional analyses...
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Abstract Autophagy regulates the degradation of damaged organelles and protein aggregates, is critical for neuronal development, homeostasis, maintenance, yet few neurodevelopmental disorders have been associated with pathogenic variants in genes encoding autophagy-related proteins. We report three individuals from two unrelated families a disorder characterized by speech motor impairment, similar facial characteristics. Rare, conserved, bi-allelic were identified ATG4D , one four ATG4...
Abstract Interaction of genetic predispositions and environmental factors via epigenetic mechanisms have been hypothesized to play a central role in Panic Disorder (PD) aetiology therapy. Cognitive Behavioral Therapy (CBT), including exposure interventions, belong the most efficient treatments PD although its biological mechanism action remains unknown. For first time, we explored dynamics magnitude DNA-methylation immune cell-type composition during CBT ( n = 38) therapeutic intervention...
In recent years, canines have been successfully used in fire investigations to detect accelerant residues. We set out determine the lower limits at which could reliably potential accelerants. Measured amounts ranging from 10 as little 0.01 microL of gasoline, kerosene, and isopars were applied preselected spots along a continuous sample path (25 40 feet long) made burned unburned wood or nylon carpeting strips testing site. Two led past this least three times positive alerts negative...
Abstract Time‐dependent photocurrent transients are measured with vapour deposited amorphous tetracene layers as a function of temperature employing the technique sensitized hole injection from selenium layer. The time dependence is exponential and reflects trapping. trap‐free mobility, derived t = 0 current amplitude, obeys μ ( T ) ∞ exp [— / 2 ] law ≈ 0.4 to 0.8 cm /Vs predicted by previous Monte Carlo computer simulations for hopping across Gaussian distribution sites in long‐time limit....
An insecure attachment style (AS), described as being highly anxious and/or avoidant, is often assumed to be stable over time, yet some studies show that AS can change. To the extent may malleable shorter time periods, it potentially impacts key therapy processes and outcomes. In present study, we first investigated stability of in patients with panic disorder (N = 49) treated short-term cognitive behavioral (CBT) including follow-up. Second, tested whether time-specific change predicted...
Background Anxiety disorders including panic disorder (PD) are the most prevalent psychiatric diseases leading to high disability and burden in general population. Acute attacks distinctive for PD but also frequent other anxiety disorders. The neurobiology or specific molecular changes present during insufficiently known so far. Methods In pilot study, we investigated dynamic metabolomic gene expression peripheral blood of patients with (n = 25) two exposure-induced acute attacks. Results...
Background Psychological stress is associated with accelerated cellular aging and increased risk for aging-related diseases, but the underlying molecular mechanisms are unclear. Methods We examined effect of on a DNA methylation age predictor that was shown to correlate strongly chronological across human tissues (Horvath 2013). Genome-wide measured in peripheral blood using 450K Illumina array three independent cohorts: Grady Trauma Project/GTP (N=366); panic disorder case/control sample...
Research Articles| March 25 2010 Chemische Schädigungen des Auges in der Arbeitsmedizin Subject Area: Ophthalmology J. Lange Gummersbach Search for other works by this author on: This Site PubMed Google Scholar Ophthalmologica (1969) 158 (1-3): 95–108. https://doi.org/10.1159/000305801 Article history Published Online: Content Tools Views Icon contents Figures & tables Video Audio Supplementary Data Peer Review Share Facebook Twitter LinkedIn Email Get Permissions Cite Citation Lange;...
Abstract This memoir recounts Barbara Hammer's relationship to the Wexner Center for Arts and its Film/Video Studio residency program, which supported a number of her films between 1994 2018. It offers some personal insight into evolution final work, Evidentiary Bodies (2018), from single-channel video multichannel installation. The author describes working with Hammer during last year life explains process organizing 2019 exhibition Hammer: In Body at Arts, premiered installation included...