Bertram Müller‐Myhsok
- Genetic Associations and Epidemiology
- Genetics and Neurodevelopmental Disorders
- Stress Responses and Cortisol
- Bipolar Disorder and Treatment
- Parkinson's Disease Mechanisms and Treatments
- Tryptophan and brain disorders
- Epigenetics and DNA Methylation
- Migraine and Headache Studies
- Reading and Literacy Development
- Restless Legs Syndrome Research
- Inflammatory Bowel Disease
- Autism Spectrum Disorder Research
- Genetic Mapping and Diversity in Plants and Animals
- Functional Brain Connectivity Studies
- Genomic variations and chromosomal abnormalities
- Genetic Syndromes and Imprinting
- Hormonal Regulation and Hypertension
- Bioinformatics and Genomic Networks
- Cognitive and developmental aspects of mathematical skills
- Birth, Development, and Health
- Child and Adolescent Psychosocial and Emotional Development
- Genomics and Rare Diseases
- Cognitive Abilities and Testing
- Mental Health Research Topics
- Multiple Sclerosis Research Studies
Max Planck Institute of Psychiatry
2016-2025
HolsboerMaschmeyer NeuroChemie (Germany)
2025
University of Liverpool
2015-2024
Munich Cluster for Systems Neurology
2015-2024
Yale University
2024
University School
2024
Synergy Health
2017-2023
Oslo University Hospital
2023
Brigham and Women's Hospital
2023
Harvard University
2023
Genetic variations, such as single nucleotide polymorphisms (SNPs) in microRNAs (miRNA) or the miRNA binding sites may affect dependent gene expression regulation, which has been implicated various cancers, including breast cancer, and alter individual susceptibility to cancer. We investigated associations between related SNPs cancer risk. First we evaluated 2,196 a case-control study combining nine genome wide association studies (GWAS). Second, further 42 with suggestive evidence for using...
Childhood maltreatment is likely to influence fundamental biological processes and engrave long-lasting epigenetic marks, leading adverse health outcomes in adulthood. We aimed elucidate the impact of different early environment on disease-related genome-wide gene expression DNA methylation peripheral blood cells patients with posttraumatic stress disorder (PTSD). Compared same trauma-exposed controls (n = 108), gene-expression profiles PTSD similar clinical symptoms matched adult trauma...
Background: The relationship between phoneme awareness, rapid automatized naming (RAN), verbal short‐term/working memory (ST/WM) and diagnostic category is investigated in control dyslexic children, the extent to which this depends on orthographic complexity. Methods: General cognitive, phonological literacy skills were tested 1,138 1,114 children speaking six different languages spanning a large range of complexity (Finnish, Hungarian, German, Dutch, French, English). Results: Phoneme...
Abstract Autophagy is an essential cellular process affecting virus infections and other diseases Beclin1 (BECN1) one of its key regulators. Here, we identified S-phase kinase-associated protein 2 (SKP2) as E3 ligase that executes lysine-48-linked poly-ubiquitination BECN1, thus promoting proteasomal degradation. SKP2 activity regulated by phosphorylation in a hetero-complex involving FKBP51, PHLPP, AKT1, BECN1. Genetic or pharmacological inhibition decreases BECN1 ubiquitination,...
Interleukin (IL)-17F, produced in IL-23R-expressing Th17 cells, is a novel member of the IL-17 cytokine family. Given association IL23R with inflammatory bowel disease (IBD), we characterized role IL-17F IBD including its intestinal gene expression and effect IL17F p.His161Arg polymorphism on susceptibility phenotype Crohn's (CD) ulcerative colitis (UC). In addition, analyzed for potential epistasis NOD2/CARD15 variants.Intestinal mRNA was measured by quantitative polymerase chain reaction...
Mood and anxiety disorders are considered stress-related diseases characterized by an impaired function of mineralocorticoid glucocorticoid receptors (MR GR, respectively), the major regulatory elements hypothalamus-pituitary-adrenocortical (HPA) axis. A number so-called chaperone proteins moderate these receptors. Genetic variations in one chaperones, FKBP5, were associated with antidepressant treatment response depression a risk-factor for development posttraumatic stress disorder. To...