A5059798545- Cardiac electrophysiology and arrhythmias
- Thyroid Cancer Diagnosis and Treatment
- Thyroid and Parathyroid Surgery
- Cardiac Arrhythmias and Treatments
- Ion channel regulation and function
- Atrial Fibrillation Management and Outcomes
- Parathyroid Disorders and Treatments
- Thyroid Disorders and Treatments
- Respiratory Support and Mechanisms
- ECG Monitoring and Analysis
- Neuroendocrine Tumor Research Advances
- Intensive Care Unit Cognitive Disorders
- Patient-Provider Communication in Healthcare
- Long-Term Effects of COVID-19
- Cardiovascular Function and Risk Factors
- Pituitary Gland Disorders and Treatments
- Growth Hormone and Insulin-like Growth Factors
- Genetic Associations and Epidemiology
- Head and Neck Anomalies
- Adrenal and Paraganglionic Tumors
- Biotin and Related Studies
- Congenital heart defects research
- Fluoride Effects and Removal
- COVID-19 diagnosis using AI
- Estrogen and related hormone effects
Maasstad Ziekenhuis
2012-2024
Gaustad Hospital
2020
Erasmus MC
2008-2017
Erasmus University Rotterdam
2011-2013
Medicines Evaluation Board
2008-2010
Ludwig-Maximilians-Universität München
2010
Massachusetts General Hospital
2010
Brigham and Women's Hospital
2010
Framingham Heart Study
2010
Genetic variants on chromosome 4q25 are associated with atrial fibrillation (AF). We sought to determine whether there is more than 1 susceptibility signal at this locus.Thirty-four haplotype-tagging single-nucleotide polymorphisms (SNPs) the locus were genotyped in 790 case and 1177 control subjects from Massachusetts General Hospital tested for association AF. replicated SNPs AF after adjustment most significantly SNP 5066 30 661 referent German Competence Network Atrial Fibrillation,...
To study whether listed putative corrected QT (QTc)-prolonging psychotropic drugs indeed prolong the QTc interval under everyday circumstances and to evaluate this is a class effect or an individual drug effect, we conducted prospective population-based cohort study.This was as part of Rotterdam Study included 3377 men 4845 women (>or=55 years) who had triennial electrocardiograms (ECGs). The primary end points were length at each ECG, difference in between consecutive ECGs within one...
Epilepsy is associated with increased risk for sudden cardiac death (SCD). We aimed to establish, in a community based study, whether this association mediated by epilepsy per se, use of antiepileptic medications (AEMs), or both.We studied SCD cases and age/sex matched controls case-control study large scale general practitioners' research database (n=478 661 patients). symptomatic (seizure <2 years before SCD), stable (no seizure AEMs (any indication) was determined.We identified 926 9832...
Common variation within the nitric oxide-1 synthase activator protein ( NOS1AP ) locus is strongly related to QT interval, a sudden cardiac death (SCD) risk factor. A recent report describes common in associated with SCD US population of European ancestry. The objective current study was obtain additional evidence by investigating association between variants and prospective population-based Rotterdam Study. consisted 5974 ancestry subjects, aged 55 years older, genotyped on Illumina arrays....
It is assumed that testosterone an important regulator of gender-related differences in ventricular repolarization. Therefore, our aim was to study whether serum levels are associated with QTc, QT and RR interval variation.two independent population-based cohort studies.445 male participants (> or =55 years) from the Rotterdam 1,428 health Pomerania (SHIP) electrocardiogram who were randomly sampled for assessment at baseline, after exclusion altering drugs, QTc prolonging drugs dig(it)oxin,...
Treatment options for Graves' disease (GD) consist of antithyroid drugs (ATD), radioactive iodine (RAI) and total thyroidectomy (TT). Guidelines recommend to discuss these with patients, taking into account patients' preferences. This study aims evaluate compare clinicians' preferences the trade-offs made in choosing treatment.A discrete choice experiment (DCE) was performed GD patients a first diagnosis or recurrence previous year, clinicians. Participants were offered hypothetical...
In the Netherlands, several reports have described a potentiation of acenocoumarol-induced anticoagulation by co-medication omeprazole or esomeprazole and competitive inhibition CYP2C19 has been suggested as possible mechanism for this interaction. We conducted an observational cohort study to investigate effects various proton pump inhibitors (PPIs) on acenocoumarol effectiveness. All 2755 subjects from Rotterdam Study who received maintenance treatment between April 1st, 1991 September...
Aims: Variant alleles of the CYP2C19 gene were recently associated with survival in breast cancer patients on tamoxifen therapy. is one enzymes involved metabolism into active metabolites. We investigated hypothesis that CYP2C19*2 and *3 variants, known for their lack enzyme activity, are an increased mortality rate using tamoxifen. Materials & methods: In prospective population based Rotterdam study, association between carriers was studied among 80 incident users Survival analyzed life...
To study whether nondiabetic persons with impaired fasting serum glucose and hyperinsulinemia have QTc/QT interval prolongation RR shortening in the electrocardiogram (ECG), these were associated an increased risk of sudden cardiac death.This consisted two analyses. First, a cross-sectional analysis was used as part population-based Rotterdam Study including 1050 men 1520 women (>or=55 years) without diabetes mellitus. Participants round 3 for whom ECG insulin measurements available eligible...
International guidelines recommend fixed cut-off values for thyroglobulin (Tg). These cut-offs do not take potential assay differences into account. This study aimed to evaluate if different assays Tg and antibodies (TgAb) affect management guidance differentiated thyroid cancer (DTC) patients.
Background and objective: The reported incidence of persistent hypoparathyroidism varies widely, consensus on a definition is lacking. objective was to evaluate the real-life by investigating new pragmatic definition. Methods: This retrospective multicenter cohort study evaluated effect different definitions for hypoparathyroidism. In addition, risk factors were analyzed. Results: total, 749 patients included. Using definition, we report an 7.9% When applying other commonly used definitions,...
Abstract Background Active surveillance is propagated as an alternative for hemithyroidectomy in the management of Bethesda III thyroid nodules. Methods A cross‐sectional survey questioned respondents on their willingness to accept risks related active and hemithyroidectomy. Results In case surveillance, (129 patients, 46 clinicians, 66 healthy controls) were willing a risk 10%–15% cancer 15% needing more extensive surgery future. Respondents 22.5%–30% hypothyroidism after Patients controls...
Thyroid free T4 is associated with QTc-interval prolongation, which a risk factor for sudden cardiac death (SCD). Hyperthyroidism has been SCD in case reports, but there are no population-based studies confirming this. The aim was to investigate whether use of antithyroid drugs (as direct cause or as an indicator poorly controlled hyperthyroidism) increased SCD.We studied the occurrence two-step procedure two different Dutch populations. First, prospective Rotterdam Study including 7898...
Aims The assessment of heart rate‐corrected QT ( QTc ) interval prolongation relies on the evidence drug effects in healthy subjects. This study demonstrates relevance pharmacokinetic–pharmacodynamic (PKPD) relationships to characterize drug‐induced and explore discrepancies between clinical trials real‐life conditions. Methods d,l ‐ S otalol data from subjects R otterdam tudy cohort were used assess treatment response a phase I setting conditions, respectively. Using modelling simulation,...