Patrick T. Ellinor
A5069822855- Atrial Fibrillation Management and Outcomes
- Cardiac electrophysiology and arrhythmias
- Genetic Associations and Epidemiology
- Cardiac Arrhythmias and Treatments
- Cardiomyopathy and Myosin Studies
- Cardiovascular Function and Risk Factors
- Genomics and Rare Diseases
- Cardiovascular Disease and Adiposity
- RNA modifications and cancer
- Ion channel regulation and function
- Lipoproteins and Cardiovascular Health
- RNA Research and Splicing
- Cardiac Imaging and Diagnostics
- Congenital heart defects research
- Cardiac pacing and defibrillation studies
- Cardiovascular Effects of Exercise
- Cancer-related gene regulation
- Health Systems, Economic Evaluations, Quality of Life
- Cardiovascular Health and Risk Factors
- Bioinformatics and Genomic Networks
- Cardiac Valve Diseases and Treatments
- Nutrition, Genetics, and Disease
- RNA and protein synthesis mechanisms
- Genomics and Chromatin Dynamics
- ECG Monitoring and Analysis
Massachusetts General Hospital
2016-2025
Broad Institute
2016-2025
Harvard University
2016-2025
Foundation Center
2022-2025
Mass General Brigham
2025
Bayer (United States)
2020-2025
Massachusetts Institute of Technology
2015-2024
Lemuel Shattuck Hospital
2023-2024
Newton Wellesley Hospital
2024
Atlanta VA Health Care System
2024
Abstract Genetic variants that inactivate protein-coding genes are a powerful source of information about the phenotypic consequences gene disruption: crucial for function an organism will be depleted such in natural populations, whereas non-essential tolerate their accumulation. However, predicted loss-of-function enriched annotation errors, and tend to found at extremely low frequencies, so analysis requires careful variant very large sample sizes 1 . Here we describe aggregation 125,748...
Abstract The Trans-Omics for Precision Medicine (TOPMed) programme seeks to elucidate the genetic architecture and biology of heart, lung, blood sleep disorders, with ultimate goal improving diagnosis, treatment prevention these diseases. initial phases focused on whole-genome sequencing individuals rich phenotypic data diverse backgrounds. Here we describe TOPMed goals design as well available resources early insights obtained from sequence data. include a variant browser, genotype...
PreambleThis international consensus statement provides the state of genetic testing for channelopathies and cardiomyopathies.It summarizes opinion writing group members based on their own experience a general review literature with respect to use role these potentially heritable cardiac conditions.This document focuses primarily 13 distinct entities detailed relative diagnostic, prognostic, therapeutic impact test result each entity.It does not focus management various...
Background Tools for the prediction of atrial fibrillation ( AF ) may identify high‐risk individuals more likely to benefit from preventive interventions and serve as a benchmark test novel putative risk factors. Methods Results Individual‐level data 3 large cohorts in U nited S tates (Atherosclerosis Risk Communities [ ARIC ] study, Cardiovascular Health Study CHS ], Framingham Heart FHS ]), including 18 556 men women aged 46 94 years (19% A frican mericans, 81% whites) were pooled derive...
Atrial fibrillation (AF) and heart failure (HF) frequently coexist together confer an adverse prognosis. The association of AF with HF subtypes has not been well described. We sought to examine differences in the temporal preserved versus reduced ejection fraction.We studied Framingham Heart Study participants new-onset or between 1980 2012. Among 1737 individuals new (mean age, 75±12 years; 48% women), more than one third (37%) had HF. Conversely, among 1166 79±11 53% half (57%) AF....
Document Reviewers: Carina Blomström-Lundqvist, MD, PhD; Angelo A.V. De Paola, Peter M. Kistler, MBBS, Gregory Y.H. Lip, MD; Nicholas S. Peters, Cristiano F. Pisani, Antonio Raviele, Eduardo B. Saad, Kazuhiro Satomi, Martin K. Stiles, MB ChB, Stephan Willems, PhD During the past three decades, catheter and surgical ablation of atrial fibrillation (AF) have evolved from investigational procedures to their current role as effective treatment options for patients with AF. Surgical AF, using...