J Engreitz
A5102868909- RNA Research and Splicing
- RNA modifications and cancer
- RNA and protein synthesis mechanisms
- Genomics and Chromatin Dynamics
- Genetic Associations and Epidemiology
- Cancer-related molecular mechanisms research
- CRISPR and Genetic Engineering
- Single-cell and spatial transcriptomics
- Bioinformatics and Genomic Networks
- HER2/EGFR in Cancer Research
- Congenital heart defects research
- Neuroblastoma Research and Treatments
- Epigenetics and DNA Methylation
- Protein Degradation and Inhibitors
- Atherosclerosis and Cardiovascular Diseases
- Chromosomal and Genetic Variations
- Genomic variations and chromosomal abnormalities
- Cancer Cells and Metastasis
- Multiple Myeloma Research and Treatments
- CAR-T cell therapy research
- Genomics and Rare Diseases
- Kruppel-like factors research
- Gene expression and cancer classification
- Pulmonary Hypertension Research and Treatments
- Monoclonal and Polyclonal Antibodies Research
Stanford University
2010-2025
Lucile Packard Children's Hospital
2011-2025
Broad Institute
2014-2024
Cardiovascular Institute of the South
2023-2024
Foundation Center
2023-2024
Novo Nordisk (United States)
2023-2024
Institute of Genetics
2024
Novo Nordisk Foundation
2023
Harvard University
2017-2021
Harvard University Press
2017-2020
Understanding Xist-ance Large noncoding RNAs (lncRNAs) are increasingly appreciated to play important roles in the cell. A number of lncRNAs act target chromatin regulatory complexes their sites action. Engreitz et al. (p. 10.1126/science.1237973 , published online 4 July; see Perspective by Dimond and Fraser ) found that mouse Xist lncRNA, which initiates X-chromosome inactivation, was transferred from its site transcription distant on X chromosome purely through close three-dimensional...
Gene expression in mammals is regulated by noncoding elements that can affect physiology and disease, yet the functions target genes of most remain unknown. We present a high-throughput approach uses clustered regularly interspaced short palindromic repeats (CRISPR) interference (CRISPRi) to discover regulatory identify their genes. assess >1 megabase sequence vicinity two essential transcription factors, MYC GATA1, nine distal enhancers control gene cellular proliferation. Quantitative...
Large-scale deep-coverage whole-genome sequencing (WGS) is now feasible and offers potential advantages for locus discovery. We perform WGS in 16,324 participants from four ancestries at mean depth >29X analyze genotypes with quantitative traits-plasma total cholesterol, low-density lipoprotein cholesterol (LDL-C), high-density triglycerides. Common variant association yields known loci except few variants previously poorly imputed. Rare coding Mendelian dyslipidemia genes but rare...
Associations between human genetic variation and clinical phenotypes have become a foundation of biomedical research. Most repositories these data seek to be disease-agnostic therefore lack disease-focused views. The Type 2 Diabetes Knowledge Portal (T2DKP) is public resource datasets genomic annotations dedicated type diabetes (T2D) related traits. Here, we make the T2DKP more accessible prospective users useful existing users. First, evaluate T2DKP's comprehensiveness by comparing its with...
Abstract Identifying transcriptional enhancers and their target genes is essential for understanding gene regulation the impact of human genetic variation on disease 1–6 . Here we create evaluate a resource >13 million enhancer-gene regulatory interactions across 352 cell types tissues, by integrating predictive models, measurements chromatin state 3D contacts, large-scale perturbations generated ENCODE Consortium 7 We first systematic benchmarking pipeline to compare assembling dataset...