Lee‐Ming Chuang
A5033802039- Diabetes Treatment and Management
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Diabetes Management and Research
- Genetic Associations and Epidemiology
- Metabolism, Diabetes, and Cancer
- Pancreatic function and diabetes
- Diabetes and associated disorders
- Adipose Tissue and Metabolism
- Adipokines, Inflammation, and Metabolic Diseases
- Liver Disease Diagnosis and Treatment
- Metabolomics and Mass Spectrometry Studies
- Diabetes Management and Education
- Peroxisome Proliferator-Activated Receptors
- Diet, Metabolism, and Disease
- RNA modifications and cancer
- Lipid metabolism and disorders
- Diet and metabolism studies
- Bariatric Surgery and Outcomes
- Chronic Kidney Disease and Diabetes
- Microbial metabolism and enzyme function
- Blood Pressure and Hypertension Studies
- Cancer, Hypoxia, and Metabolism
- Alcohol Consumption and Health Effects
- Inflammatory mediators and NSAID effects
- Regulation of Appetite and Obesity
National Taiwan University Hospital
2016-2025
National Taiwan University
2016-2025
National Yang Ming Chiao Tung University
2007-2023
Chung Shan Hospital
2021
Beth Israel Deaconess Medical Center
2021
Mitsubishi Corporation (Japan)
2015-2016
Taipei Institute of Pathology
2003-2016
SK Group (Japan)
2015
JW Pharmaceutical (South Korea)
2015
Icahn School of Medicine at Mount Sinai
2015
Adiponectin, an adipose tissue-specific plasma protein, was recently revealed to have anti-inflammatory effects on the cellular components of vascular wall. Its levels were significantly lower in men than women and human subjects with obesity, type 2 diabetes mellitus, or coronary artery disease. Therefore, it may provide a biological link between obesity obesity-related disorders such as atherosclerosis, against which confer protection. In this study, we observed changes adiponectin body...
<h3>Importance</h3>Controlling glycemia, blood pressure, and cholesterol is important for patients with diabetes. How best to achieve this goal unknown.<h3>Objective</h3>To compare Roux-en-Y gastric bypass lifestyle intensive medical management control of comorbid risk factors.<h3>Design, Setting, Participants</h3>A 12-month, 2-group unblinded randomized trial at 4 teaching hospitals in the United States Taiwan involving 120 participants who had a hemoglobin A<sub>1c</sub> (HbA<sub>1c</sub>)...
OBJECTIVE—Adiponectin, a plasma protein exclusively synthesized and secreted by adipose tissue, has recently been shown to have anti-inflammatory, antiatherogenic properties in vitro beneficial metabolic effects animals. Lower levels of adiponectin documented human subjects with syndrome coronary artery disease. We investigated whether the level this putative protective adipocytokine could be increased treatment peroxisome proliferator-activated receptor-γ (PPAR-γ) agonist diabetic patients....
To investigate the underlying mechanisms of T2D pathogenesis, we looked for diabetes susceptibility genes that increase risk type 2 (T2D) in a Han Chinese population. A two-stage genome-wide association (GWA) study was conducted, which 995 patients and 894 controls were genotyped using Illumina HumanHap550-Duo BeadChip first genome scan stage. This further replicated 1,803 1,473 stage 2. We found two loci not previously associated with around protein tyrosine phosphatase receptor D (PTPRD)...
<h3>Importance</h3> The Roux-en-Y gastric bypass is effective in achieving established diabetes treatment targets, but durability unknown. <h3>Objective</h3> To compare of added to intensive lifestyle and medical management control targets. <h3>Design, Setting, Participants</h3> Observational follow-up a randomized clinical trial at 4 sites the United States Taiwan, involving 120 participants who had hemoglobin A<sub>1c</sub>(HbA<sub>1c</sub>) level 8.0% or higher body mass index between...
Background— Microvascular renal and retinal diseases are common major complications of type 2 diabetes mellitus. The relation between plasma lipids microvascular disease is not well established. Methods Results— case subjects were 2535 patients with mellitus an average duration 14 years, 1891 whom had kidney 1218 retinopathy. matched for duration, age, sex, low-density lipoprotein cholesterol to 3683 control who did have or study was conducted in 24 sites 13 countries. primary analysis...
Large-scale deep-coverage whole-genome sequencing (WGS) is now feasible and offers potential advantages for locus discovery. We perform WGS in 16,324 participants from four ancestries at mean depth >29X analyze genotypes with quantitative traits-plasma total cholesterol, low-density lipoprotein cholesterol (LDL-C), high-density triglycerides. Common variant association yields known loci except few variants previously poorly imputed. Rare coding Mendelian dyslipidemia genes but rare...
Abstract Type 2 diabetes (T2D) is a heterogeneous disease that develops through diverse pathophysiological processes 1,2 and molecular mechanisms are often specific to cell type 3,4 . Here, characterize the genetic contribution these across ancestry groups, we aggregate genome-wide association study data from 2,535,601 individuals (39.7% not of European ancestry), including 428,452 cases T2D. We identify 1,289 independent signals at significance ( P < 5 × 10 −8 ) map 611 loci, which 145...
Abstract Several recent advances provide multiple health benefits to individuals with type 2 diabetes mellitus (T2DM). Pharmacological therapy is governed by person‐centered factors, including comorbidities and treatment goals. Adults T2DM who have an established/high risk of atherosclerotic cardiovascular disease, heart failure, and/or chronic kidney require a regimen that includes agents are proven reduce cardiorenal risk. Weight management plays key role in reducing glucose for patients...
OBJECTIVE—To study the effect of birth weight on risk type 2 diabetes in schoolchildren Taiwan. RESEARCH DESIGN AND METHODS—From 1992 to 1997, all aged 6–18 years were screened for Taiwan Province. This cohort consisted 1,966 patients with and 1,780 randomly selected subjects normal fasting glycemia (NFG). Questionnaire interviewing was designed classify diabetes. The obtained from Taiwan’s Birth Registry. After merging data, there 978 subjects, including 429 549 NFG enrolled present...
Abstract Objective: Hypoadiponectin has been documented in subjects with obesity, diabetes mellitus, or coronary heart disease, suggesting a potential use of plasma adiponectin following the clinical progress metabolic syndrome (MS). In this study, we investigated levels relation to variables MS among overweight/obese Asian subjects. Research Methods and Procedures: The adiponectin, anthropometric biochemical measurements, oral glucose tolerance tests (OGTT), modified insulin suppression...
Genetic variants in the fat mass and obesity-associated (FTO) gene have been linked with obesity type 2 diabetes European populations. We aimed to test role of FTO genetic Chinese population.
To find clinically meaningful preoperative predictors of diabetes remission and conversely inadequate glycemic control after gastric bypass surgery. Predicting the improvement in those with type 2 bariatric surgery may help patient selection.Preoperative details 154 ethnic Chinese subjects were examined for their influence on outcomes at 1 year bypass. Remission was defined as HbA(1c) ≤6%. Analysis involved binary logistic regression to identify provide equations receiver operating...
Waist circumference (WC) is used to define central obesity. This study aimed compare the performance of two recommended locations WC measurement.A cohort 1,898 subjects who were without diabetes from 2006 2012 followed for a median 31 months (Taiwan Lifestyle Study). The WC-IC, by National Cholesterol Education Program Third Adult Treatment Panel, was measured at superior border iliac crest, and WC-mid, World Health Organization International Diabetes Federation, midway between lowest ribs...
Genetic polymorphisms of the transcription factor 7-like 2 (TCF7L2) gene is one few validated genetic variants with large effects on risk type diabetes in populations European ancestry. In this study, we aimed to explore effect TCF7L2 a Han Chinese population.We genotyped 20 single nucleotide (SNPs) across 1,520 unrelated subjects from population Taiwan. The associations SNPs and haplotypes linkage disequilibrium (LD) structure were analyzed.The previously reported rs7903146 T- rs12255372...