Daniel I. Chasman
- Genetic Associations and Epidemiology
- Nutrition, Genetics, and Disease
- Lipoproteins and Cardiovascular Health
- Migraine and Headache Studies
- Genetic Mapping and Diversity in Plants and Animals
- Bioinformatics and Genomic Networks
- Adipokines, Inflammation, and Metabolic Diseases
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Metabolomics and Mass Spectrometry Studies
- Genomics and Rare Diseases
- Lipid metabolism and disorders
- Genetic and phenotypic traits in livestock
- Birth, Development, and Health
- Neuroscience of respiration and sleep
- Cancer-related molecular mechanisms research
- Obesity, Physical Activity, Diet
- Liver Disease Diagnosis and Treatment
- RNA modifications and cancer
- Cancer, Lipids, and Metabolism
- Epigenetics and DNA Methylation
- Diet, Metabolism, and Disease
- Cardiovascular Disease and Adiposity
- Adipose Tissue and Metabolism
- Atherosclerosis and Cardiovascular Diseases
- Cardiovascular Health and Risk Factors
Brigham and Women's Hospital
2016-2025
Harvard University
2016-2025
Broad Institute
2010-2025
Massachusetts General Hospital
2010-2024
Harvard University Press
2009-2023
Framingham Heart Study
2010-2023
National Heart Lung and Blood Institute
2011-2023
National Institutes of Health
2023
Boston Children's Hospital
2018-2023
Bordeaux Population Health
2022
Abstract Genetic variants that inactivate protein-coding genes are a powerful source of information about the phenotypic consequences gene disruption: crucial for function an organism will be depleted such in natural populations, whereas non-essential tolerate their accumulation. However, predicted loss-of-function enriched annotation errors, and tend to found at extremely low frequencies, so analysis requires careful variant very large sample sizes 1 . Here we describe aggregation 125,748...
Abstract The Trans-Omics for Precision Medicine (TOPMed) programme seeks to elucidate the genetic architecture and biology of heart, lung, blood sleep disorders, with ultimate goal improving diagnosis, treatment prevention these diseases. initial phases focused on whole-genome sequencing individuals rich phenotypic data diverse backgrounds. Here we describe TOPMed goals design as well available resources early insights obtained from sequence data. include a variant browser, genotype...
Both genetic and lifestyle factors contribute to individual-level risk of coronary artery disease. The extent which increased can be offset by a healthy is unknown.
Structural variants (SVs) rearrange large segments of DNA
Temporal increases in the consumption of sugar-sweetened beverages have paralleled rise obesity prevalence, but whether intake such interacts with genetic predisposition to adiposity is unknown.We analyzed interaction between and relation body-mass index (BMI; weight kilograms divided by square height meters) risk 6934 women from Nurses' Health Study (NHS) 4423 men Professionals Follow-up (HPFS) also a replication cohort 21,740 Women's Genome (WGHS). The genetic-predisposition score was...