A5004023037- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Diet, Metabolism, and Disease
- Single-cell and spatial transcriptomics
- Alcohol Consumption and Health Effects
- Coffee research and impacts
- Liver Diseases and Immunity
- Health Literacy and Information Accessibility
- Immune cells in cancer
- Food Security and Health in Diverse Populations
- Artificial Intelligence in Healthcare
- Obesity, Physical Activity, Diet
- Diabetes Treatment and Management
- Antimicrobial Peptides and Activities
- Diabetes Management and Research
- Drug-Induced Hepatotoxicity and Protection
- Nutritional Studies and Diet
- Inflammatory Bowel Disease
- Hepatitis B Virus Studies
- Social Media in Health Education
- Nicotinic Acetylcholine Receptors Study
- Immune responses and vaccinations
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Diet and metabolism studies
- Adipose Tissue and Metabolism
Harvard University
2021-2025
VA Pittsburgh Healthcare System
2025
University of Pittsburgh Medical Center
2023-2025
University of Pittsburgh
2024
Beth Israel Deaconess Medical Center
2021-2024
Universidad Anáhuac
2018-2020
Abstract The SARS-CoV-2 pandemic has caused over 1 million deaths globally, mostly due to acute lung injury and respiratory distress syndrome, or direct complications resulting in multiple-organ failures. Little is known about the host tissue immune cellular responses associated with COVID-19 infection, symptoms, lethality. To address this, we collected tissues from 11 organs during clinical autopsy of 17 individuals who succumbed COVID-19, a bank approximately 420 specimens. We generated...
Objectives: Metabolic dysfunction-associated steatotic liver disease (MASLD), an increasing public health concern, remains challenging to diagnose and risk-stratify. We assessed the 1) prevalence of MASLD risk factors among Veterans in Health Administration (VA) care, 2) associated with diagnosis; 3) associations between diagnosis receipt care. Methods: factors, including obesity, pre-diabetes, diabetes, or dyslipidemia, were identified using International Classification Diseases-10 codes...
Abstract Background The molecular underpinnings of organ dysfunction in severe COVID-19 and its potential long-term sequelae are under intense investigation. To shed light on these the context liver function, we perform single-nucleus RNA-seq spatial transcriptomic profiling livers from 17 decedents. Results We identify hepatocytes positive for SARS-CoV-2 RNA with an expression phenotype resembling infected lung epithelial cells, a central role pro-fibrotic TGFβ signaling cell–cell...
Abstract Despite being widely recognized as a common cause of fatty liver, the exact impact alcohol consumption on hepatic steatosis in general population is elusive. The recent National Health and Nutrition Examination Survey (NHANES) allowed us to examine this relationship among US adults. Herein, we extracted data detailed controlled attenuation parameter (CAP) by FibroScan from 4509 participants NHANES 2017‐2018. Compared metabolic risk factors such diabetes obesity, association between...
The molecular underpinnings of organ dysfunction in acute COVID-19 and its potential long-term sequelae are under intense investigation. To shed light on these the context liver function, we performed single-nucleus RNA-seq spatial transcriptomic profiling livers from 17 decedents. We identified hepatocytes positive for SARS-CoV-2 RNA with an expression phenotype resembling infected lung epithelial cells. Integrated analysis comparisons healthy controls revealed extensive changes cellular...
Background Chronic disease, such as heart failure, influences cellular metabolism and shapes circulating metabolites. The relationships between key energy metabolites chronic diseases in aging are not well understood. This study aims to determine the relationship main components of with all-cause mortality incident failure. Methods Results We analyzed association plasma metabolite levels failure among US older adults CHS (Cardiovascular Health Study). followed 1758 participants without at...
Abstract Background and study aims Colonoscopy is an effective tool to prevent colorectal cancer. Social media has emerged as a source of medical information for patients.YouTube (a video sharing website) the most popular informative source. Therefore, we aimed assess educational quality colonoscopy videos available on YouTube. Methods We performed YouTube search using keyword “colonoscopy” yielded 429 videos, which 255 met inclusion criteria. Data Quality Score (C-DQS) was created rate (–10...
Background: Infections frequently complicate hospital admission among patients with cirrhosis and are associated adverse outcomes. In specific settings, administration of prophylactic antibiotics has been shown to improve this pilot study, we aimed assess the feasibility a randomized study whether ceftriaxone (CTX), administered hospitalized advanced (Model for End-Stage Liver Disease-Sodium ≥ 18) without known infection, could reduce incidence infection. We also sought determine identify...
Cirrhosis, a rising cause of death in the United States, has an extended preclinical phase characterized by progressive liver fibrosis. Despite developments noninvasive fibrosis measurement, there is no recommended screening, part due to incomplete understanding disease epidemiology on national scale. Herein, we aim define prevalence and compare strategies identify at‐risk population. We analyzed 4,510 US adults with complete stiffness measurement (LSM) vibration‐controlled transient...
Introduction: The Hispanic population in the US faces a higher risk of nonalcoholic fatty liver disease (NAFLD). Multiple factors influence this risk, including genetics, environmental factors, and socioeconomic statuses. Inadequate access to nutritious foods, or food insecurity, is prevalent among individuals poses metabolic for both onset development NAFLD. Materials Methods: We utilized National Health Nutrition Examination Survey (NHANES) 2017-2020 pre-pandemic data analyze association...
Abstract Background and Aims Lipoprotein Z (LP‐Z) is an abnormal free cholesterol (FC)–enriched LDL‐like particle discovered from patients with cholestatic liver disease. This study aims to define the diagnostic value of LP‐Z in alcohol‐associated hepatitis (AH) interrogate biology behind its formation. Approach Results We measured serum levels using nuclear magnetic resonance spectroscopy, a well‐established clinical assay. Serum were significantly elevated four AH cohorts compared control...
Introduction: Colonoscopy is one of the most effective methods to prevent colorectal cancer. Social media has emerged as a source medical information for patients, which YouTube, video sharing website, popular informative sources. Therefore, we aimed assess educational quality colonoscopy videos available on YouTube. Methods: We performed YouTube search using keyword “colonoscopy” from 9th 18th September 2017. The initial yielded 429 out 255 were included in analysis summarized Fig 1....