A5032878842- Aerodynamics and Acoustics in Jet Flows
- Education Systems and Policy
- Amyloidosis: Diagnosis, Treatment, Outcomes
- IgG4-Related and Inflammatory Diseases
- Traumatic Brain Injury and Neurovascular Disturbances
- Acoustic Wave Phenomena Research
- Neuroendocrine Tumor Research Advances
- Traumatic Brain Injury Research
- Vasculitis and related conditions
- Cancer Immunotherapy and Biomarkers
- Lung Cancer Treatments and Mutations
- Fibroblast Growth Factor Research
- COVID-19 Clinical Research Studies
- Diverse Educational Innovations Studies
- Cardiac Structural Anomalies and Repair
- Management and Marketing Education
- Aortic aneurysm repair treatments
- Combustion and flame dynamics
- Lung Cancer Research Studies
- Abdominal vascular conditions and treatments
- Vehicle Noise and Vibration Control
- Gastrointestinal disorders and treatments
- Higher Education and Employability
- Computational Fluid Dynamics and Aerodynamics
- Eosinophilic Disorders and Syndromes
University of Virginia
2014-2025
Massachusetts General Hospital
2015-2024
Harvard University
2015-2024
Beth Israel Deaconess Medical Center
2024
University of British Columbia
2024
Dalhousie University
2024
National Clinical Research
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
The University of Texas Health Science Center at Houston
2023
Stone Clinic
2023
PD-1 inhibitors are established agents in the management of non-small cell lung cancer (NSCLC); however, only a subset patients derives clinical benefit. To determine activity PD-1/PD-L1 within clinically relevant molecular subgroups, we retrospectively evaluated response patterns among EGFR-mutant, anaplastic lymphoma kinase (ALK)-positive, and EGFR wild-type/ALK-negative patients.We identified 58 treated with inhibitors. Objective rates (ORR) were assessed using RECIST v1.1. PD-L1...
John H. Stone, Arezou Khosroshahi, Vikram Deshpande, K. C. Chan, J. Godfrey Heathcote, Rob Aalberse, Atsushi Azumi, Donald B. Bloch, William R. Brugge, Mollie N. Carruthers, Wah Cheuk, Lynn Cornell, Carlos Fernandez-Del Castillo, Judith A. Ferry, David Forcione, Gunter Kloppel, Daniel L. Hamilos, Terumi Kamisawa, Satomi Kasashima, Shigeyuki Kawa, Mitsuhiro Kawano, Yasufumi Masaki, Kenji Notohara, Kazuichi Okazaki, Ji Kon Ryu, Takako Saeki, Dushyant Sahani, Yasuharu Sato, Thomas Smyrk, James...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSoluble Guanylate Cyclase from Bovine Lung: Activation with Nitric Oxide and Carbon Monoxide Spectral Characterization of the Ferrous Ferric StatesJames R. Stone Michael A. MarlettaCite this: Biochemistry 1994, 33, 18, 5636–5640Publication Date (Print):May 10, 1994Publication History Published online1 May 2002Published inissue 10 1994https://pubs.acs.org/doi/10.1021/bi00184a036https://doi.org/10.1021/bi00184a036research-articleACS...
Background The mechanisms of extracellular matrix changes accompanying myxomatous valvular degeneration are uncertain. Methods and Results To test the hypothesis that interstitial cells mediate degradation in by excessive secretion catabolic enzymes, we examined functional characteristics 14 mitral valves removed for from patients with regurgitation 11 normal obtained at autopsy. Immunohistochemical staining assessed (1) cell phenotype using antibodies to α-actin (microfilaments), vimentin...
Genetic alterations in the fibroblast growth factor receptor (FGFR) pathway are promising therapeutic targets many cancers, including intrahepatic cholangiocarcinoma (ICC). The FGFR inhibitor BGJ398 displayed encouraging efficacy patients with FGFR2 fusion-positive ICC a phase II trial, but durability of response was limited some patients. Here, we report molecular basis for acquired resistance to three via integrative genomic characterization cell-free circulating tumor DNA (cfDNA), primary...
IgG4-related disease (IgG4-RD) can cause fibroinflammatory lesions in nearly any organ. Correlation among clinical, serologic, radiologic, and pathologic data is required for diagnosis. This work was undertaken to develop validate an international set of classification criteria IgG4-RD.An multispecialty group 86 physicians assembled by the American College Rheumatology (ACR) European League Against Rheumatism (EULAR). Investigators used consensus exercises, existing literature, derivation...
Coronavirus disease 2019 (COVID-19) due to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has been associated with cardiovascular features of myocardial involvement including elevated serum troponin levels and heart failure reduced ejection fraction. The cardiac pathological changes in these patients COVID-19 have yet be well described.In an international multicentre study, tissue from the autopsies 21 consecutive was assessed by pathologists. presence myocarditis, as defined...
Objective The development of practice parameters for intravenous analgesia and sedation adult patients in the intensive care unit (ICU) setting purpose guiding clinical practice. Participants A task force more than 40 experts disciplines related to use analgesic sedative agents ICU was convened from membership American College Critical Care Medicine (ACCM) Society (SCCM). Evidence members provided personal experience determined published literature (MEDLINE articles, textbooks,...
Crizotinib, an inhibitor of anaplastic lymphoma kinase (ALK), has also recently shown efficacy in the treatment lung cancers with ROS1 translocations. Resistance to crizotinib developed a patient metastatic adenocarcinoma harboring CD74-ROS1 rearrangement who had initially dramatic response treatment. We performed biopsy resistant tumor and identified acquired mutation leading glycine-to-arginine substitution at codon 2032 domain. Although this does not lie gatekeeper residue, it confers...
IgG4-related disease (IgG4-RD) is a heterogeneous, multiorgan condition of unclear aetiology that can cause organ failure. Difficulty recognising IgG4-RD contributes to diagnostic delays. We sought identify key phenotypes.We used two cross-sectional studies assembled by an international, multispecialty network specialists who submitted 765 cases derive and replicate phenotypic groups. Phenotype groups manifestations covariate distributions across the identified were measured using latent...
Abstract Aims Myocarditis is a potentially fatal complication of immune checkpoint inhibitors (ICI). Sparse data exist on the use cardiovascular magnetic resonance (CMR) in ICI-associated myocarditis. In this study, CMR characteristics and association between features events among patients with myocarditis are presented. Methods results From an international registry myocarditis, clinical, CMR, histopathological findings were collected. Major adverse (MACE) composite death, cardiogenic...
The interleukin-6 pathway is up-regulated in giant cell arteritis (GCA), Takayasu (TA), and polymyalgia rheumatica (PMR). We retrospectively assessed the outcomes of 10 patients with relapsing/refractory GCA, TA, or PMR treated tocilizumab (TCZ).Patients GCA (n = 7), TA 2), 1) received TCZ. Seven subjects had failed at least 1 second-line agent. evaluated were symptoms disease activity, inflammatory markers, ability to taper glucocorticoids, cross-sectional imaging when indicated...