A5005013150- IgG4-Related and Inflammatory Diseases
- Neuroendocrine Tumor Research Advances
- Gastrointestinal disorders and treatments
- Pancreatic and Hepatic Oncology Research
- Pancreatitis Pathology and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Gallbladder and Bile Duct Disorders
- Soft tissue tumor case studies
- Pediatric Hepatobiliary Diseases and Treatments
- Liver Disease Diagnosis and Treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Lung Cancer Diagnosis and Treatment
- Gastric Cancer Management and Outcomes
- Renal cell carcinoma treatment
- Abdominal vascular conditions and treatments
- Renal Diseases and Glomerulopathies
- MRI in cancer diagnosis
- Drug Transport and Resistance Mechanisms
- Photoacoustic and Ultrasonic Imaging
- Radiomics and Machine Learning in Medical Imaging
- Organ Transplantation Techniques and Outcomes
- Medical Imaging Techniques and Applications
- Inflammatory Biomarkers in Disease Prognosis
- Liver Disease and Transplantation
Tokyo Metropolitan Tama Medical Center
2016-2025
Kanazawa University Hospital
2015-2025
Kanazawa University
2015-2024
Obayashi (Japan)
2022
Kanazawa Medical University
2011-2021
Shinshu University
2019
Matsumoto Dental University
2019
Kansai Medical University
2019
Tokyo Metropolitan Komagome Hospital
2019
Kurashiki Central Hospital
2019
IgG4-related disease (IgG4RD) is a novel clinical entity characterized by elevated serum IgG4 concentration and tumefaction or tissue infiltration IgG4-positive plasma cells. IgG4RD may be present in certain proportion of patients with wide variety diseases, including Mikulicz's disease, autoimmune pancreatitis, hypophysitis, Riedel thyroiditis, interstitial pneumonitis, nephritis, prostatitis, lymphadenopathy, retroperitoneal fibrosis, inflammatory aortic aneurysm, pseudotumor. Although...
IgG4-related disease (IgG4-RD) can cause fibroinflammatory lesions in nearly any organ. Correlation among clinical, serologic, radiologic, and pathologic data is required for diagnosis. This work was undertaken to develop validate an international set of classification criteria IgG4-RD.An multispecialty group 86 physicians assembled by the American College Rheumatology (ACR) European League Against Rheumatism (EULAR). Investigators used consensus exercises, existing literature, derivation...
Immunoglobulin G4-related disease (IgG4-RD) is a recently discovered systemic condition, in which various organ manifestations are linked by similar histological appearance. Our knowledge of this condition still fragmented, as most studies have examined only few dozen patients or focused on particular manifestation. This study was conducted to learn the demography and patient characteristics IgG4-RD using large cohort. A total 235 consecutive with IgG4-RD, diagnosed 8 general hospitals same...
Immunoglobulin G4 (IgG4)-related disorders can occur in the respiratory system. However, clinicopathologic characteristics have not been well clarified. In this study, we examined clinical and pathologic features of, follow-up data on, IgG4-related lung pleural lesions. The patients group consisted of 17 males 4 females with an average age 69 years (range: 42 to 76). Pulmonary lesions 16 5 were examined. Histologically, all showed diffuse lymphoplasmacytic infiltration. Irregular fibrosis...
To retrospectively analyze radiologic findings of immunoglobulin G4 (IgG4)-related lung disease as correlated with pathologic specimens.This study was approved by the institutional review board, and all patients had consented to use their medical records for purpose research. This included 13 IgG4-related (nine men four women; age range, 43-76 years). Computed tomographic (CT) were analyzed regard characteristics, shape, distribution surgically resected or biopsy specimens in seven patients....
The possible involvement of immunoglobulin G4 (IgG4) in the pathogenesis idiopathic sclerosing lesions has been suggested. In this study, a clinicopathologic analysis was performed to reveal characteristics retroperitoneal fibrosis relating IgG4. study involved 17 patients with fibrosis. Immunohistochemistry revealed numerous IgG4-positive plasma cell infiltrates 10 cases (IgG4-related), but only few positive cells 7 (non-IgG4-related). All IgG4-related were male, whereas all except 1...
Clinical Practice Guidelines for Pancreatic Cancer was first published in 2006 by the Japan Pancreas Society, and revised 2009, 2013, 2016, 2019. In July 2022, newly Japanese.For this revision, we developed an entirely new guideline according to Minds Manual Guideline Development 2020, which includes concepts of GRADE-Grading Recommendations Assessment, Development, Evaluation, enable a better understanding current guidelines. Patients public were actively involved both development...
To retrospectively evaluate computed tomographic (CT) findings of immunoglobulin G4 (IgG4)-related disease involving the vascular system.This study was approved by institutional review board, and all patients included had consented to use their medical records for purpose research. The consisted 17 (16 men one woman; age range, 54-86 years). CT IgG4-related periarterial lesions were analyzed. Radiopathologic correlations examined on basis surgically resected specimens.A total 22 detected in...
Abstract IgG4‐related sclerosing cholangitis (IgG4‐ SC ) is a distinct type of frequently associated with autoimmune pancreatitis and currently recognized as biliary manifestation disease. Although clinical diagnostic criteria IgG4‐ were established in 2012, differential diagnosis from primary cholangiocarcinoma sometimes difficult. Furthermore, no practical guidelines for are available. Because the evidence level most articles retrieved through searching PubMed, Cochrane Library, Igaku Chuo...
Background Differentiation between multicentric Castleman's disease and systemic immunoglobulin (Ig) G4-related lymphadenopathy is sometimes difficult. It has been suggested that measurement of the IgG4-/IgG-positive cell ratio useful for differential diagnosis two diseases. However, authors present a detailed report six patients with abundant IgG4-positive cells (IgG4-/IgG-positive ratio, >40%). Results In series, showed lymphadenopathy, polyclonal hypergammaglobulinaemia elevated serum...
Immunoglobulin G4 (IgG4)–related aortitis/periaortitis and periarteritis are vascular manifestations of IgG4-related disease. In this disease, the affected aneurysmal lesion has been suspected to be at risk rupture. study, we aimed clarify clinical course after corticosteroid therapy in periarteritis. We retrospectively evaluated features, including laboratory data, imaging findings therapy, 40 patients diagnosed with on basis periaortic/periarterial radiological findings, satisfaction...
Abstract Background In preparing the Japanese (JPN) guidelines for management of acute pancreatitis 2021, committee focused issues raised by results nationwide epidemiological survey in 2016 Japan. Method addition to a systematic search using previous JPN guidelines, papers published from January 2014 September 2019 were searched contents be covered based on concept GRADE system. Results Thirty‐six clinical questions (CQ) prepared 15 subject areas. Based facts that patients diagnosed with...
Abstract In 2023, the Japan Pancreas Society (JPS) published new eighth edition of Japanese classification pancreatic carcinoma. We present here an excerpted version in English, based on latest edition. The major changes this revision are as follows: Union for International Cancer Control (UICC), T category was changed to be tumor size; however, retains previous local invasion factors. Lymph nodes have been renamed, and regional lymph defined by location. Peritoneal cytology, which not...
Aims. To elucidate characteristics of IgG4-related disease involving the peripheral nervous system. Methods. Retrospective review 106 patients with identified 21 nerve lesions in 7 patients. Clinicopathological and radiological features were examined. Results. Peripheral commonly orbital or paravertebral area, ( ), optic spinal great auricular nerves ). The predominant feature was a distinct perineural soft tissue mass, ranging 8 to 30 mm diameter. Histologically, epineurium preferentially...
Purpose To identify the imaging features of hepatocellular carcinoma (HCC) associated with β-catenin mutation and their relationship to pathologic findings. Materials Methods Institutional ethics committee approval informed consent were obtained. One hundred thirty-eight surgically resected HCCs analyzed in this study. Immunohistochemical expression its transcriptional product, glutamine synthetase (GS), graded classified into three groups: positive GS group (HCC mutation), negative...
ObjectiveRecent studies suggest that systemic inflammatory response is closely associated with cancer patient prognosis. Although several prognostic markers have been proposed, the data to support their validity are lacking in large Japanese cohorts.
Deep learning has shown great promise for improving medical image classification tasks. However, knowing what aspects of an the deep system uses or, in a manner speaking, sees to make its prediction is difficult.Within radiologic imaging context, we investigated utility methods designed identify features within images on which activates. In this study, developed classifier contrast enhancement phase from whole-slice CT data. We then used as easily interpretable explore class activation map...