A5024734268- IgG4-Related and Inflammatory Diseases
- Neuroendocrine Tumor Research Advances
- Gastrointestinal disorders and treatments
- Pancreatitis Pathology and Treatment
- Immunodeficiency and Autoimmune Disorders
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Vasculitis and related conditions
- Galectins and Cancer Biology
- T-cell and B-cell Immunology
- Platelet Disorders and Treatments
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Systemic Sclerosis and Related Diseases
- Long-Term Effects of COVID-19
- Autoimmune Bullous Skin Diseases
- Immunotherapy and Immune Responses
- Systemic Lupus Erythematosus Research
- Vascular Malformations and Hemangiomas
- Otitis Media and Relapsing Polychondritis
- Immune responses and vaccinations
- Autoimmune and Inflammatory Disorders
- Salivary Gland Tumors Diagnosis and Treatment
- Inflammatory Myopathies and Dermatomyositis
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Salivary Gland Disorders and Functions
Ragon Institute of MGH, MIT and Harvard
2017-2024
Massachusetts General Hospital
2015-2024
Harvard University
2015-2024
National Clinical Research
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
Radiology Associates
2024
National Cancer Institute
2022
National Institute of Arthritis and Musculoskeletal and Skin Diseases
2022
National Institutes of Health
2022
National Center for Complementary and Integrative Health
2022
The efficacy of interleukin-6 receptor blockade in hospitalized patients with coronavirus disease 2019 (Covid-19) who are not receiving mechanical ventilation is unclear. We performed a randomized, double-blind, placebo-controlled trial involving confirmed severe acute respiratory syndrome 2 (SARS-CoV-2) infection, hyperinflammatory states, and at least two the following signs: fever (body temperature >38°C), pulmonary infiltrates, or need for supplemental oxygen order to maintain an...
IgG4-related disease (IgG4-RD) can cause fibroinflammatory lesions in nearly any organ. Correlation among clinical, serologic, radiologic, and pathologic data is required for diagnosis. This work was undertaken to develop validate an international set of classification criteria IgG4-RD.An multispecialty group 86 physicians assembled by the American College Rheumatology (ACR) European League Against Rheumatism (EULAR). Investigators used consensus exercises, existing literature, derivation...
IgG4-related disease (IgG4-RD) is a heterogeneous, multiorgan condition of unclear aetiology that can cause organ failure. Difficulty recognising IgG4-RD contributes to diagnostic delays. We sought identify key phenotypes.We used two cross-sectional studies assembled by an international, multispecialty network specialists who submitted 765 cases derive and replicate phenotypic groups. Phenotype groups manifestations covariate distributions across the identified were measured using latent...
Systemic sclerosis (SSc) is an autoimmune fibrotic disease whose pathogenesis poorly understood and lacks effective therapies. We undertook quantitative analyses of T cell infiltrates in the skin 35 untreated patients with early diffuse SSc here show that CD4+ cytotoxic cells CD8+ contribute prominently to these infiltrates. also observed accumulation apoptotic tissues, suggesting recurring death may tissue damage remodeling this disease. HLA-DR-expressing endothelial were frequent targets...
Objectives: IgG4-related disease (IgG4-RD) is an immune-mediated fibroinflammatory condition that can affect multiple organs and lead to tumefactive, tissue-destructive lesions. Reports have described inflammatory aortitis periaortitis, the latter in setting of retroperitoneal fibrosis (RPF), but not distinguished adequately between these 2 manifestations. The frequency, radiologic features, response vascular complications B cell depletion remain poorly defined. We describe clinical...
Objective IgG4‐related disease (IgG4‐ RD ) can cause fibroinflammatory lesions in nearly any organ, leading to organ dysfunction and failure. The IgG4‐ Responder Index ( RI was developed help investigators assess the efficacy of treatment a structured manner. aim this study validate multinational investigation. Methods guides through assessments activity damage 25 domains, incorporating higher weights for manifestations that require urgent or worsen despite treatment. After training...
An unconventional population of CD4+ signaling lymphocytic activation molecule family member 7-positive (SLAMF7+) cytotoxic effector memory T (TEM ) cells (CD4+ lymphocytes [CTLs]) has been linked causally to IgG4-related disease (IgG4-RD). Glucocorticoids represent the first-line therapeutic approach in patients with IgG4-RD, but their mechanism action this specific condition remains unknown. We undertook study determine impact glucocorticoids on CTLs IgG4-RD.Expression CD8α, granzyme A,...
Although therapeutic B cell depletion dramatically resolves inflammation in many diseases which antibodies appear not to play a central role, distinct extrafollicular pathogenic subsets that accumulate disease lesions have hitherto been identified. The circulating immunoglobulin D (IgD)
IgG4-related disease is a multiorgan, relapsing, fibroinflammatory, immune-mediated disorder with no approved therapy. Inebilizumab targets and depletes CD19+ B cells may be effective for treating patients disease. In this phase 3, multicenter, double-blind, randomized, placebo-controlled trial, adults active underwent randomization in 1:1 ratio to receive inebilizumab (300-mg intravenous infusions on days 1 15 week 26) or placebo 52-week treatment period. Participants both groups received...
Abstract Background Immunoglobulin G4-related disease (IgG4-RD) and systemic sclerosis (SSc) are rare autoimmune diseases characterized by the presence of CD4+ cytotoxic T cells in blood as well inflammation fibrosis various organs, but they have no established etiologies. Similar to other diseases, gut microbiome might encode disease-triggering or disease-sustaining factors. Methods The microbiomes from IgG4-RD SSc patients healthy individuals with recent antibiotic treatment were studied...
Objective Four autoantigens have been described recently in IgG4‐related disease (IgG4‐ RD ): prohibitin, annexin A11, laminin 511‐E8, and galectin‐3. However, no external validation has performed, the possibility that some individuals break tolerance to more than 1 autoantigen not explored. We undertook this study evaluate relative frequencies of antibody responses against these order explore role adaptive immune response IgG4‐ . Methods Autoantibody 511‐E8 were measured among a clinically...
Immunoglobulin G4-related disease (IgG4-RD) is a debilitating multiorgan characterized by recurring flares leading to organ dysfunction, decreased quality of life, and mortality. Glucocorticoids, the standard care for IgG4-RD, are associated with substantial treatment-related toxicity. Inebilizumab, an antibody directed against CD19, mediates rapid durable depletion CD19+ B cells thought be involved in IgG4-RD pathogenesis. We describe first international, prospective, double-blind,...