A5013362448- IgG4-Related and Inflammatory Diseases
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University of Toyama
2015-2024
Toyama University Hospital
2015-2024
Toyama College
2021
Health First
1998-2017
Tohoku Medical and Pharmaceutical University
1993-2016
Tohoku University
2016
University of Shizuoka
2016
Kyoto University
2012-2013
National Institute of Technology, Maizuru College
2012
Osaka University
1994
Journal Article Comprehensive diagnostic criteria for IgG4-related disease (IgG4-RD), 2011 Get access Hisanori Umehara, Umehara Department of Hematology and Immunology, Kanazawa Medical University, Kanazawa, JapanDivision Internal Medicine, 1-1 Daigaku, Uchinada-machi, Kahoku-gun, Ishikawa 920-0293, Japan Correspondence to: Kazuichi Okazaki, e-mail: umehara@kanazawa-med.ac.jp Search other works by this author on: Oxford Academic Google Scholar Okazaki Division Gastroenterology Hepatology,...
IgG4-related disease (IgG4-RD) is a novel clinical entity characterized by elevated serum IgG4 concentration and tumefaction or tissue infiltration IgG4+ plasma cells. Although IgG4-RD not rare clinically important, its diagnostic criteria have been established. Comprehensive for IgG4-RD, including the involvement of various organs, are intended practical use general physicians nonspecialists. Background: Methods: Two study groups, Umehara Okazaki teams, were organized Ministry Health, Labor...
IgG4-related disease (IgG4RD) is a novel clinical entity characterized by elevated serum IgG4 concentration and tumefaction or tissue infiltration IgG4-positive plasma cells. IgG4RD may be present in certain proportion of patients with wide variety diseases, including Mikulicz's disease, autoimmune pancreatitis, hypophysitis, Riedel thyroiditis, interstitial pneumonitis, nephritis, prostatitis, lymphadenopathy, retroperitoneal fibrosis, inflammatory aortic aneurysm, pseudotumor. Although...
<h3>Background:</h3> Mikulicz's disease (MD) has been considered as one manifestation of Sjögren's syndrome (SS). Recently, it also an IgG<sub>4</sub>-related disorder. <h3>Objective:</h3> To determine the differences between disorders including MD and SS. <h3>Methods:</h3> A study was undertaken to investigate patients with registered in Japan set up provisional criteria for new clinical entity IgG<sub>4</sub>-positive multiorgan lymphoproliferative (IgG<sub>4</sub>+MOLPS). The preliminary...
IgG4-related disease (IgG4-RD) is a fascinating clinical entity first reported in this century Japan, and includes wide variety of diseases, such as formerly named Mikulicz's (MD), autoimmune pancreatitis (AIP), interstitial nephritis, prostatitis retroperitoneal fibrosis. The Japanese IgG4 team organized by the Ministry Health, Labor Welfare (MHLW) Japan has published criteria, comprehensive diagnostic (CD) criteria for IgG-RD 2011. Thereafter, IgG4-RD been accepted widely many cases have...
IgG4-related disease is a new classification established in Japan the 21st century. Patients with display hyper-IgG4-gammaglobulinemia, massive infiltration of IgG4+ plasma cells into tissue, and good response to glucocorticoids. Since IgG4 overexpression also observed other disorders, it necessary diagnose carefully correctly. We therefore sought determine cutoff values for serum IgG4/IgG IgG4+/IgG+ tissue diagnostic disease. Methods . retrospectively analyzed concentrations ratio cell...
Objective IgG4‐related disease (IgG4‐ RD ) can cause fibroinflammatory lesions in nearly any organ, leading to organ dysfunction and failure. The IgG4‐ Responder Index ( RI was developed help investigators assess the efficacy of treatment a structured manner. aim this study validate multinational investigation. Methods guides through assessments activity damage 25 domains, incorporating higher weights for manifestations that require urgent or worsen despite treatment. After training...
The aim was to further characterize immunoglobulin G4-related disease (IgG4-RD) by a large-scale multicenter study of its clinical and laboratory features conducted multidisciplinary physicians IgG4-RD in Japan.Various specialists retrospectively evaluated patients diagnosed between 1996 2015 five hospitals analyzing their baseline features, laboratory, imaging, pathological test findings, treatment.Of the 334 listed, 205 were male median age at diagnosis 65 years. mean number organs...
Abstract Background and objective Immunoglobulin G4 ( IgG4 )‐related disease is a multi‐organ disorder that can include the lungs. ‐related lung present in various forms; clinical, radiological pathological features of patients with this have been assessed. Methods Forty‐eight suspected having disease, high serum concentration abundant ‐positive plasma cell infiltration into intrathoracic organs, were retrospectively evaluated. Their clinical features, chest imaging findings examined, final...
Immunoglobulin G4 (IgG4)–related aortitis/periaortitis and periarteritis are vascular manifestations of IgG4-related disease. In this disease, the affected aneurysmal lesion has been suspected to be at risk rupture. study, we aimed clarify clinical course after corticosteroid therapy in periarteritis. We retrospectively evaluated features, including laboratory data, imaging findings therapy, 40 patients diagnosed with on basis periaortic/periarterial radiological findings, satisfaction...
ABSTRACT Background and objective: In asthma, reduced histone deacetylase activity enhanced acetyltransferase in the lungs have been reported. However, precise function of Sirtuin 1 (Sirt1), a class III deacetylase, effect Sirt1 activator SRT1720 on allergic inflammation not fully elucidated. Methods: The SRT1720, synthetic Sirt1, an ovalbumin (OVA)‐induced asthma mouse model was investigated. resveratrol OVA stimulation splenocytes from OVA‐sensitized challenged mice also examined. Results:...
Although glucocorticoids are effective for patients with IgG4-related disease, the treatment has not yet been standardized. Therefore, strategy should be established.Patients who fulfilled comprehensive diagnostic criteria definite disease were started on prednisolone (0.6 mg/kg body weight) dose reduced every two weeks. The subsequent maintenance and need determined individual patients. primary endpoint was complete remission (CR) rate at one year. Secondary endpoints included overall...
Progressively transformed germinal centers is a benign condition of unknown pathogenesis characterized by distinctive variant form reactive follicular hyperplasia in lymph nodes. We recently reported Ig G4-related disease progressively centers. However, no large case series has been and clinicopathologic findings remain unclear. Here, we report 40 Japanese patients (28 men, 12 women; median age, 56 years) with the nodes who fulfilled histological diagnostic criteria for IgG4-related (IgG4+...
Abstract Glucocorticoids (GC) are effective for treating IgG4-related disease (IgG4-RD); however, relapse is often observed. We conducted a retrospective multicentre study to investigate risk factors in GC regimens associated with relapses of IgG4-RD. Data on 166 patients definitive IgG4-RD diagnosis were collected from 12 institutions. Comprehensive surveillance clinical backgrounds and as well multivariate analysis treatment responses was performed. To determine the initial maximal dose,...
Bradykinin (BK) is a major kinin with well-documented pharmacological properties including vascular leakage and induction of variety cytokines. However, the intracellular signalling mechanisms by which BK induced proinflammatory cytokine production have not been fully elucidated. This study investigated role extracellular signal-regulated protein kinase 1/2 (ERK 1/2) p38 mitogen-activated (p38 MAPK) in BK-induced interleukin (IL)-6 IL-8 human lung fibroblasts. Lung fibroblasts were...
Abstract— Thin sections prepared from the olfactory cortex of guinea pig were incubated in a medium containing [ 14 C]glutamate, and release radioactive compounds electrical activity subsequently examined presence l ‐cysteate. The postsynaptic potential was almost completely suppressed ‐cysteate, whereas presynaptic unaffected. Repetitive stimulation excitatory input lateral tract enhanced glutamate. facilitatory effect increased with increase stimulus frequency dependent on calcium. Release...
Objective To determine whether the creatinine/cystatin C (Cr/CysC) ratio, which is influenced by muscle mass, can be used as a predictive marker of adverse effects chemotherapy. Methods This single-centre, retrospective, observational study assessed patients with lung cancer. Serum Cr and CysC levels were measured once within 1 month prior commencement Results A total 25 cancer enrolled in study: 22 received first-line therapy; three second-line therapy. significant difference was noted...
Radiation pneumonitis is a major complication of radiation therapy. However, the detailed cellular mechanisms have not been clearly defined. Based on recognition that basement membrane disruption occurs in acute lung injury and matrix metalloproteinase (MMP)-2 can degrade type IV collagen, one components membrane, we hypothesized ionizing would modulate MMP-2 production human epithelial cells. To evaluate this, modulation with irradiation was investigated normal bronchial cells as well A549...
'Immunoglobulin G4 (IgG4)-related disease' is a new clinical concept of multi-organ diseases, with Mikulicz's disease (MD) being phenotype IgG4-related disease. To clarify the characteristics respiratory involvement associated MD, we retrospectively assessed 25 patients 11 (44%) whom had allergic symptoms, and 7 (28%) complained problems. Thirteen (52%) presented pulmonary and/or mediastinal lesions (P-MD) on chest computed tomography (CT), limited to lacrimal salivary glands (L-MD). Mean...