A5052337090- Chemical Synthesis and Reactions
- Inorganic and Organometallic Chemistry
- Sulfur-Based Synthesis Techniques
- Organic and Inorganic Chemical Reactions
- Salivary Gland Tumors Diagnosis and Treatment
- Radical Photochemical Reactions
- Chemical Reaction Mechanisms
- Sarcoma Diagnosis and Treatment
- Chemical Reactions and Mechanisms
- Gastric Cancer Management and Outcomes
- Organic Chemistry Cycloaddition Reactions
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Neuroendocrine Tumor Research Advances
- Ear and Head Tumors
- Oral and Maxillofacial Pathology
- Metastasis and carcinoma case studies
- Cancer Diagnosis and Treatment
- Oxidative Organic Chemistry Reactions
- Ruminant Nutrition and Digestive Physiology
- Lung Cancer Diagnosis and Treatment
- Synthesis and Catalytic Reactions
- Soft tissue tumor case studies
- Pancreatic and Hepatic Oncology Research
- Mollusks and Parasites Studies
- Pediatric Hepatobiliary Diseases and Treatments
Yawata Medical Center
2020-2025
Ishikawa Prefectural Central Hospital
2001-2024
Kanazawa Medical University Hospital
2009-2020
Kanazawa Medical University
2010-2019
Kyushu Institute of Technology
2013
Niigata University
2012
Kyoto University
2009
Kanazawa University Hospital
1998-2008
Kanazawa University
1998-2008
University of Occupational and Environmental Health Japan
2006
Recently, attention has been drawn to papillary neoplasm of the pancreatobiliary systems. In pancreas, disease entity intraductal mucinous (IPMN-P) is widely recognized. contrast, pathological characteristics biliary tumors, such as papilloma(tosis) and cholangiocarcinoma, have not yet well documented. this study, we compared features post-operative prognosis among tumors (10 cases 22 cholangiocarcinoma), conventional non-papillary cholangiocarcinoma (15 cases), IPMN-P (31 cases)....
Chronic sclerosing sialadenitis (CSS) is a cryptogenic tumor-like condition of the salivary gland(s). While immune-mediated processes are suspected in its pathogenesis, and CSS occasionally reported to be associated with pancreatitis, an IgG4-related disease, exact immunopathologic remain speculative. In this study, we examined clinicopathologic findings (12 cases) comparison sialolithiasis (8 Sjögren's syndrome (13 cases), tried clarify whether disease or not. Submandibular gland(s) were...
Recently the authors proposed a new staging and grading system for primary biliary cirrhosis (PBC) that takes into account necroinflammatory activity histological heterogeneity. Herein is convenient version of this system. Scores fibrosis, bile duct loss, chronic cholestasis were combined staging: stage 1, total score 0; 2, 1–3; 3, 4–6; 4, 7–9. Cholangitis (CA) hepatitis (HA) graded as CA0–3, HA0–3, respectively. Analysis interobserver agreement was then conducted. Digital images 62 needle...
An invasive micropapillary component has been described in tumors of several organs and is nearly always associated with aggressive biologic behavior. We present 14 cases salivary duct carcinoma (SDC) an (invasive SDC) compare the clinicopathologic findings these those conventional SDC. The mean age patients (10 men, 4 women) was 65.8 years (range, 26-80 years). size 2.4 cm 1.3-5 cm). parotid gland involved 12 submandibular 2. Histologically, all had architecture admixed features typical for...
IgG4-related disease is a new classification established in Japan the 21st century. Patients with display hyper-IgG4-gammaglobulinemia, massive infiltration of IgG4+ plasma cells into tissue, and good response to glucocorticoids. Since IgG4 overexpression also observed other disorders, it necessary diagnose carefully correctly. We therefore sought determine cutoff values for serum IgG4/IgG IgG4+/IgG+ tissue diagnostic disease. Methods . retrospectively analyzed concentrations ratio cell...
A diagnosis of low-grade fibromyxoid sarcoma (LGFMS) remains problematic because its bland-looking histologic features that can be potentially confused with other benign or lesions. Recent cytogenetic and molecular analyses have shown most LGFMSs a characteristic chromosomal abnormality, t(7;16)(q33;p11), resulting in the FUS-CREB3L2 fusion gene. However, such assays only rarely been used to analyze formalin-fixed, paraffin-embedded tumor samples. In present study, we conducted reverse...
The histogenesis and biological behaviour of peripheral intrahepatic cholangiocarcinoma (peripheral CC) remain unclarified. aim this study was to examine the growth pattern CC (24 cases) in comparison with hepatocellular carcinoma (HCC, 27 metastatic colorectal adenocarcinoma (MCA, 24 cases).Tumour/surrounding liver borders were classified as: (i) fibrous encapsulation, (ii) compressive growth, (iii) infiltrating replacement. Nineteen CCs showed (iii), whereas 23 HCCs 17 MCAs (ii). In cells...
Recently, great attention has been drawn to IgG4-related diseases such as autoimmune pancreatitis (AIP) sclerosing sialadenitis, retroperitoneum fibrosis, cholangitis. are characterized by high serum IgG4 concentrations, inflammation with numerous IgG4-positive plasma cells, and steroid sensitivity irrespective of their organs origin. In this report, we describe a case nonspecific interstitial pneumonia, in which possible involvement was suggested. The patient 59-year-old man, who found have...
Abstract The mechanism of the reaction tetraethylenepentamine (TEPA) with cumene hydroperoxide (CHP) and iron ions was investigated. It found that (1) TEPA did not reduce Fe(III); (2) consumed by this reaction; (3) both Fe(II) Fe(III) were effective for reaction. shown though OO bond a could be cleaved only at elevated temperatures, it easily iron–TEPA complex. function complex is discussed.
Abstract Objectives: To identify useful biomarkers for differentiating between malignant mesothelioma (MM) and reactive mesothelial cells (RMCs). Methods: Formalin-fixed, paraffin-embedded (FFPE) tissues from 34 MM 40 RMC samples were analyzed using immunohistochemistry, the findings compared. Results: Positive markers included insulin-like growth factor 2 messenger RNA binding protein 3 (IMP3), glucose transporter 1 (GLUT1), epithelial membrane antigen (EMA), CD146, which showed...
Cancer stem-like cells (CSCs) are expanded in the CSC niche by increased frequency of symmetric cell divisions at expense asymmetric divisions. The division CSCs is important for malignant properties cancer; however, underlying molecular mechanisms remain largely elusive. Here, we show a cytokine, semaphorin 3 (Sema3), produced from niche, induces to expand population. Our findings indicate that stimulation with Sema3 induced sphere formation breast cancer through neuropilin 1 (NP1) receptor...
Aims Five cases of angiomyolipoma (AML) composed exclusively or predominantly smooth muscle cells (SMC) are presented to emphasize the histological diversity and caution against errors in diagnosis. Methods results Four tumours were located liver one renal capsule. Three patients female two male, ranging from 36 76 years age with a mean 50 years. One patient capsular tumour was associated tuberous sclerosis. Two spindle‐shaped SMC component, whereas three others epithelioid elements. AMLs...
Sclerosing mesenteritis is a rare inflammatory and fibrosing disorder of unknown etiology, while IgG4‐related disease (IgG4‐RD) consists mass‐forming, fibroinflammatory lesions characterized by high serum IgG4 levels tissue infiltration many IgG4‐positive plasma cells; obliterative phlebitis common. This report describes case sclerosing that was considered manifestation IgG4‐RD. A 53‐year‐old man underwent right hemicolectomy because an ileocecal mass did not improve with conservative...
Cancer stem cells are thought to be responsible for tumor growth, recurrence, and resistance conventional cancer therapy. However, it is still unclear how they maintained in tissues. Here, we show that the growth differentiation factor 15 (GDF15), a member of TGFβ family, may maintain stem-like breast tissues by inducing its own expression an autocrine/paracrine manner. We found GDF15, but not TGFβ, increased sphere formation several cell lines patient-derived primary cells. As expected,...