A5070733768- Sarcoma Diagnosis and Treatment
- Soft tissue tumor case studies
- Bone Tumor Diagnosis and Treatments
- Ear and Head Tumors
- Vascular Tumors and Angiosarcomas
- Salivary Gland Tumors Diagnosis and Treatment
- Gastrointestinal disorders and treatments
- Cancer and Skin Lesions
- Soft tissue tumors and treatment
- Gastrointestinal Tumor Research and Treatment
- Parathyroid Disorders and Treatments
- Cardiac tumors and thrombi
- Medical Imaging and Pathology Studies
- Colorectal Cancer Treatments and Studies
- Peptidase Inhibition and Analysis
- RNA modifications and cancer
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Pancreatic and Hepatic Oncology Research
- Genetic factors in colorectal cancer
- Lymphoma Diagnosis and Treatment
- Tumors and Oncological Cases
- Gastric Cancer Management and Outcomes
- Esophageal and GI Pathology
- Musculoskeletal synovial abnormalities and treatments
- Advanced Neuroimaging Techniques and Applications
Uji Hospital
2022-2024
University of Occupational and Environmental Health Japan
2010-2020
Saiseikai Yahata General Hospital
2015
Fujita Health University
2003-2004
Saga Medical School Hospital
1999-2003
Clear cell sarcoma (CCS) of soft tissue is a rare with morphologic similarities to malignant melanoma but distinct genetic background including chromosomal translocation, t(12;22)(q13;q12), or resultant EWSR1-ATF1 fusion gene. In addition, the tumors occurring in gastrointestinal tract may have variant gene EWSR1-CREB1. This study analyzed clinicopathologic and molecular features 33 CCSs tissue. The patients' ages ranged from 13 73 years (median, 30 y), there was male predominance (20 males,...
Aims The diagnosis of epithelioid haemangioendothelioma (EHE) is usually straightforward, based on characteristic histological features. However, it sometimes difficult to differentiate EHE from a variety other tumours with morphology. WW domain‐containing transcription regulator 1–calmodulin‐binding activator 1 ( WWTR1–CAMTA1 ) fusion gene, resulting in the overexpression CAMTA1, demonstrated approximately 90% EHEs, and yes‐associated protein 1–transcription factor E3 YAP1–TFE3 associated...
A diagnosis of low-grade fibromyxoid sarcoma (LGFMS) remains problematic because its bland-looking histologic features that can be potentially confused with other benign or lesions. Recent cytogenetic and molecular analyses have shown most LGFMSs a characteristic chromosomal abnormality, t(7;16)(q33;p11), resulting in the FUS-CREB3L2 fusion gene. However, such assays only rarely been used to analyze formalin-fixed, paraffin-embedded tumor samples. In present study, we conducted reverse...
Undifferentiated sarcoma harboring the BCOR-CCNB3 fusion is characterized by its predilection to affect skeletons of adolescent males, cellular small round/spindle cell morphology, and CCNB3 immunoreactivity. We analyzed 11 cases sarcoma, 10 which were identified in a reverse transcription-polymerase chain reaction–based screen 85 patient samples recorded our database as unclassified round or spindle sarcomas. BCOR rearrangements confirmed fluorescence situ hybridization 8 tumors. All...
Abstract MicroRNAs (miRNAs) are noncoding small RNAs that function as an endogenous regulator of gene expression. Their dysregulation has been implicated in the development several cancers. However, status miRNA soft tissue sarcomas not yet thoroughly investigated. This study examined global expression synovial sarcoma and compared results to those another translocation‐associated sarcoma, Ewing family tumors, normal skeletal muscle. The 3D‐Gene microarray platform (Toray, Kamakura, Japan)...
Pathologic lesions caused by lanthanum carbonate (LC), a recently developed phosphate-binding agent, have not been recorded. A peculiar gastroduodenal histiocytic lesion associated with mucosal overload was reported. Our routine gastrointestinal biopsy series included 6 cases heavy burden in the mucosa. In addition to histopathologic examinations, of immunohistochemical analysis and electron microscopic examinations x-ray diffraction elemental were performed. Six cases, 3 male female...
PLAG1 , a proto‐oncogene activated in several types of tumors including pleomorphic adenoma the salivary gland and lipoblastoma, is usually overexpressed because chromosomal aberrations resulting fusion genes. Myoepithelial soft tissue are morphologically similar to adenoma, but genetic profiles these have not been fully examined. In present study, we immunohistochemically evaluated expression series 243 mesenchymal tumors. We determined that 14 tumors, eight 10 lipoblastomas, two seven...
Phosphaturic mesenchymal tumors (PMTs) are rare neoplasms that often associated with tumor-induced osteomalacia (TIO) due to excessive serum levels of fibroblast growth factor 23 (FGF23). PMTs share overlapping histologic features other types tumors; thus, accurate pathological diagnosis may be challenging. We performed an immunohistochemical examination FGF23 expression in and tumors, together pertinent molecular analyses. Seven (5 TIO 2 without TIO) 46 bone soft tissue were retrieved,...
Metastatic cardiac tumors are known to occur more frequently than primary tumors, however, they often remain asymptomatic and commonly discovered on autopsy. Malignant with a relatively high frequency of metastasis include mesothelioma, melanoma, lung cancer, breast whereas reports esophageal cancer rare.
Aims: To investigate the clinicopathological characteristics of 20 primary gastric T‐cell lymphoma (GTCL) cases without human T‐lymphotropic virus type I infection in Japan, a non‐endemic area for coeliac disease. Methods and results: Fifteen had no history persistent diarrhoea or severe hypoproteinaemia. Histologically, 13 (65%) consisted large cell seven (35%) were medium‐sized cells. Intraepithelial invasion was found three (15%). Two 10 surgical (20%) showed intramucosal tumour spreading...
Soft‐tissue sarcomas can be divided into translocation‐associated (TA) and non‐TA sarcomas, the latter of which is often characterized by pleomorphic cytomorphology aneuploidy. The aberrant expression MAD2, an essential component mitotic spindle checkpoint, has been recently shown to promote aim present paper was assess MAD2 status on immunohistochemistry in 50 TA with known fusion genes sarcomas. overexpressed 26 (52%) 33 (66%). Notably, overexpression frequently detected atypical or...
Mitochondrial transcription factor A (mtTFA) is necessary for both and maintenance of mitochondrial DNA. This study was conducted to elucidate the clinicopathologic prognostic significance mtTFA in patients with endometrial carcinoma. investigated relationship between immunohistochemical expression various clinicopathological variables 276 carcinomas, including 245 endometrioid adenocarcinomas 31 nonendometrioid carcinomas (21 serous 10 clear cell adenocarcinomas). Both uni- multivariate...