A5105230819- Neuroendocrine Tumor Research Advances
- Gastric Cancer Management and Outcomes
- Metastasis and carcinoma case studies
- Renal cell carcinoma treatment
- Lung Cancer Treatments and Mutations
- Sarcoma Diagnosis and Treatment
- Salivary Gland Tumors Diagnosis and Treatment
- Gastrointestinal Tumor Research and Treatment
- Pancreatic and Hepatic Oncology Research
- Inflammatory Bowel Disease
- Medical Imaging and Pathology Studies
- Ear and Head Tumors
- Hepatocellular Carcinoma Treatment and Prognosis
- Tumors and Oncological Cases
- Neonatal Respiratory Health Research
- Lymphoma Diagnosis and Treatment
- Pancreatitis Pathology and Treatment
- Neuroblastoma Research and Treatments
- Tracheal and airway disorders
- Bladder and Urothelial Cancer Treatments
- Liver Disease Diagnosis and Treatment
- Ovarian cancer diagnosis and treatment
- Oral and Maxillofacial Pathology
- Cancer Genomics and Diagnostics
- Congenital Diaphragmatic Hernia Studies
Yokohama City University
2016-2025
Yokohama City University Medical Center
2016-2025
Yokohama City University Hospital
2004-2013
Japan Surgical Society
2012
Hiratsuka Kyosai Hospital
2010
University of Occupational and Environmental Health Japan
2008
University of Southern California
2004
St. Marianna University School of Medicine
2004
Kanagawa Cardiovascular and Respiratory Center
1992-2002
Kanagawa Dental University
2001
Clear cell sarcoma (CCS) of soft tissue is a rare with morphologic similarities to malignant melanoma but distinct genetic background including chromosomal translocation, t(12;22)(q13;q12), or resultant EWSR1-ATF1 fusion gene. In addition, the tumors occurring in gastrointestinal tract may have variant gene EWSR1-CREB1. This study analyzed clinicopathologic and molecular features 33 CCSs tissue. The patients' ages ranged from 13 73 years (median, 30 y), there was male predominance (20 males,...
Abstract The gene expression profiles of 33 renal cell carcinomas (RCCs) and nine normal kidney samples were examined using high‐density oligonucleotide microarrays in an attempt to identify biomolecular markers for the diagnosis tumour subtypes also prediction prognosis. Hierarchical clustering demonstrated that clear‐cell RCC, chromophobe tissue showed distinctive profiles. mean levels 149 12 500 genes more than three times higher RCC tissue. Among whose was upregulated adipose...
Seven cases of high-grade adenocarcinoma fetal lung type (H-FLAC) are compared with nine pulmonary endodermal tumor resembling or low-grade (L-FLAC). Of the seven patients H-FLAC, four were men and three women. All but one in their 60s 70s. Five smokers. After resection tumor, died metastases, two alive no evidence disease, a postoperative complication. Histologically, H-FLAC L-FLAC have both complex glandular structures neuroendocrine differentiation. Two had stromal proliferation typical...
Atypical adenomatous hyperplasia (AAH) of the lung is a putative precursor bronchoalveolar carcinoma (BAC). To define steps in its development and to clarify at which stage critical cellular events occur, we studied 65 lesions AAH, early BAC, overt BAC by morphometric analysis immunohistochemical evaluation expression p53 protein carcinoembryonic antigen (CEA). Both nuclear area lesion size increased from AAH BAC; standardized variation was smallest BAC. Discriminant using these parameters...
Prostate cancer (PCa) is the most common malignant carcinoma that develops in men Western countries. MicroRNA (miRNA) have potential to be used as biomarkers and therapeutic targets for treatment of various cancers. We found significantly higher expression miR-30d 3 PCa cell lines (PC3, DU145 LNCaP) compared with 2 normal prostate (RWPE-1 PrSc) using miRNA microarrays qPCR. Clinicopathological study revealed levels were tissue samples than paired controls (P = 0.03). Furthermore,...
Our recent retrospective study revealed a significantly reduced risk of bladder cancer (BC) recurrence in men who received androgen deprivation therapy (ADT) for their prostate cancer. However, whether receptor (AR) signals contributed to the preventive effect ADT remained unclear because could reduce serum estrogens as well. The purpose this is investigate associations between expression AR/estrogen receptors (ERs) and BC patients treated with ADT. We immunohistochemically stained 72 BCs 42...
ABSTRACT Background and Aim Qualitative diagnosis of ulcerative colitis–associated neoplasia (UCAN) is crucial for surveillance colonoscopy in patients with colitis (UC). Although the utility magnifying endoscopy narrow‐band imaging (ME‐NBI) sporadic has been reported, its efficacy UCAN remains unclear. This study aimed to evaluate usefulness ME‐NBI qualitative UCAN. Methods We generated 60 images (30 UCANs 30 nonneoplasia lesions, including 10 polypoid 20 nonpolypoid lesions) from UC who...
Esophageal squamous cell carcinoma (ESCC) in patients with no history of tobacco smoking or alcohol consumption accounts for approximately 5% all ESCCs. This study aimed to clarify the clinicopathological features superficial ESCCs consumption. Clinical data and pathological 108 endoscopic submucosal dissection (ESD) specimens obtained from 102 (NTNA group) were reviewed. For comparison, 767 ESD 544 (TA also Factors analyzed included age, sex, synchronous/metachronous cancer,...
It is now known that gene mutation of beta-catenin with subsequent nuclear/cytoplasmic (N/C) overaccumulation the protein plays an important role in tumorigenesis various organs. We recently demonstrated low-grade adenocarcinoma fetal lung type (L-FLAC)/well-differentiated (WDFA), epithelial prototype classic pulmonary blastoma (CPB), shows N/C localization genetic mutation. This prompted us to further investigate state abnormality CPB and related neoplasms. studied 9 tumors previously...
Pulmonary artery dissection in patients without underlying pulmonary hypertension Aims : (PA) is a rare event which usually occurs with hypertension. We describe two who developed PA pre‐existing and present an extensive review of the literature. Methods results In first patient (a 59‐year‐old woman), acute‐onset dyspnoea was initially thought to have been caused by thrombosis, thromboendarterectomy performed. Histologically, external rupture evident, chiefly right main PA. second patient,...
BACKGROUND The differential diagnosis between reactive mesothelial cells (RMs), malignant mesotheliomas (MMs), and adenocarcinomas (ACs) is often difficult in cytologic specimens, the utility of various immunohistochemical markers have been explored. Because recent immunohistologic studies suggested that E-cadherin (E-cad) calretinin (Cal) may be useful for epithelial differentiations, respectively, authors investigated their diagnosis. METHODS In this retrospective study, immunostaining was...
To determine whether the 2005 International Society of Urologic Pathology (ISUP) Gleason Grading Consensus is clinically more useful than conventional score (CGS), we compared CGS and ISUP GS (IGS) prostate needle biopsy (NB) radical prostatectomy (RP) specimens, evaluated prognostic value GS.Of 250 patients undergoing RP, 103 with clinical stage T1-2 N0M0 were enrolled. Pathological tumour grades NB RP specimens classified according to by experienced pathologists in central pathology...
The maximum standard uptake value (SUVmax) of the whole body on 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) reflects tumor aggressiveness in non-Hodgkin lymphoma (NHL). To clarify correlation between SUVmax at biopsy site and proliferation potential cells, we studied 36 patients with untreated NHL five Hodgkin (HL) by measuring Ki-67 index (MIB-1 labeling index) specimens. measured MIB-1 was categorized into seven levels: nearly 0%, 5-20%, 21-40%, 41-60%, 61-80%, 81-95%,...
Abstract Background Colorectal cancer is one of the major neoplasms and a leading cause death worldwide, new preventive strategies are needed to lower burden this disease. Metformin, biguanide, which widely used for treating diabetes mellitus, has recently been suggestive have suppressive effect on tumorigenesis cell growth. In previous study conducted in non-diabetic subjects, we showed that oral short-term low-dose metformin suppressed development colorectal aberrant crypt foci (ACF). ACF...
High-grade fetal adenocarcinoma (H-FLAC) is a rare variant of pulmonary adenocarcinoma; this study aims to elucidate its clinicopathological features and genetic abnormalities.Clinicopathological, immunohistochemical mutational analyses were performed on 20 surgically resected lung cancers that showed H-FLAC histology in various proportions. These tumours predominantly occurred elderly males 10 patients who heavy smokers. Four cases pure H-FLAC, 16 mixed which found be combined with...