A5067077344- Adipose Tissue and Metabolism
- Pancreatic function and diabetes
- Food composition and properties
- Liver Disease Diagnosis and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Metabolism, Diabetes, and Cancer
- Diabetes and associated disorders
- Regulation of Appetite and Obesity
- Advancements in Battery Materials
- Microbial Metabolites in Food Biotechnology
- Peripheral Artery Disease Management
- Hormonal Regulation and Hypertension
- Glioma Diagnosis and Treatment
- Aortic aneurysm repair treatments
- Adipokines, Inflammation, and Metabolic Diseases
- Adrenal and Paraganglionic Tumors
- Diet and metabolism studies
- bioluminescence and chemiluminescence research
- Dialysis and Renal Disease Management
- Advanced Battery Materials and Technologies
- Biofuel production and bioconversion
- Vascular Procedures and Complications
- Diet, Metabolism, and Disease
- Epilepsy research and treatment
- Diabetes Management and Research
Shinshu University
2016-2025
Saitama International Medical Center
2022-2025
Tokyo Medical and Dental University
2018-2024
Ogaki Municipal Hospital
2020-2024
Gifu University
1997-2024
Tokai Gakuen University
2024
Ōtani University
2016-2023
The University of Tokyo
2001-2023
Nagoya Ekisaikai Hospital
2022-2023
Gifu Pharmaceutical University
2019-2022
Coordinated control of energy metabolism and glucose homeostasis requires communication between organs tissues. We identified a neuronal pathway that participates in the cross talk liver adipose tissue. By studying mouse model, we showed adenovirus-mediated expression peroxisome proliferator-activated receptor (PPAR)-g2 induces acute hepatic steatosis while markedly decreasing peripheral adiposity. These changes were accompanied by increased expenditure improved systemic insulin sensitivity....
Metabolic regulation in mammals requires communication between multiple organs and tissues. The rise the incidence of obesity associated metabolic disorders, including type 2 diabetes, has renewed interest interorgan communication. We used mouse models to explore mechanism whereby enhances pancreatic β cell mass, pathophysiological compensation for insulin resistance. found that hepatic activation extracellular regulated kinase (ERK) signaling induced proliferation through a...
Several clinical studies of statin therapy have demonstrated that lowering low-density lipoprotein (LDL) cholesterol prevents atherosclerotic progression and decreases cardiovascular mortality. In addition, oxidized LDL (oxLDL) is suggested to play roles in the formation atherosclerosis. However, whether oxLDL alone, rather than total LDL, affects atherogenesis remains unclear.To clarify atherogenic impact oxLDL, lectin-like receptor 1 (LOX-1), an receptor, was expressed ectopically liver...
Although aromatic compounds occupy a central position in organic chemistry, antiaromatic have demonstrated little practical utility. Herein we report the application of an compound as electrode-active material rechargeable batteries. The performance dimesityl-substituted norcorrole nickel(II) complex (NiNC) cathode-active was examined with Li metal anode. A maximum discharge capacity about 207 mAhg(-1) maintained after 100 charge/discharge cycles. Moreover, bipolar redox property NiNC...
Nuclear factor-κB (NF-κB) signaling plays critical roles in physiological and pathological processes such as responses to inflammation oxidative stress.To examine the role of endothelial NF-κB vivo, we generated transgenic mice expressing dominant-negative IκB under Tie2 promoter/enhancer (E-DNIκB mice). These exhibited functional inhibition specifically cells. Although E-DNIκB displayed no overt phenotypic changes when young lean, they were protected from development insulin resistance...
Four methods were evaluated for isolating exosomes from bovine milk: (1) ExoQuick precipitation, (2) ultracentrifugation with (3) density gradient centrifugation, and (4) human milk exosome isolation. Methods 1 4 failed due to differences between milk. Exosomes efficiently isolated by either precipitation (method 2) or centrifugation 3). The highest yield of was achieved using whereas higher quality isolation intact morphological structures centrifugation.
During fasting, animals maintain their energy balance by shifting source from carbohydrates to triglycerides. However, the trigger for this switch has not yet been entirely elucidated. Here we show that a selective hepatic vagotomy slows speed of fat consumption attenuating sympathetic nerve-mediated lipolysis in adipose tissue. Hepatic glycogen pre-loading adenoviral overexpression synthase or transcription factor TFE3 abolished liver–brain–adipose axis activation. Moreover, blockade...
Obesity represents chronic inflammatory states promoted by pro-inflammatory M1-macrophage infiltration into white adipose tissue (WAT), thereby inducing insulin resistance. Herein, we demonstrate the importance of an ER stress protein, CHOP, in determining macrophage (ATM) polarity and systemic sensitivity. A high-fat diet (HFD) enhances with CHOP upregulation adipocytes. deficiency prevents HFD-induced resistance glucose intolerance ATM M2 predomination Th2 cytokine WAT. Whereas suppresses...
Metformin is the first-line drug in treatment of type 2 diabetes. In addition to its hypoglycemic effect, metformin has an anti-inflammatory function, but precise mechanism promoting this activity remains unclear. High mobility group box 1 (HMGB1) alarmin that released from necrotic cells and induces inflammatory responses by cytokine-like is, therefore, a target therapies. Here we identified HMGB1 as novel metformin-binding protein affinity purification using biotinylated analogue. directly...
Major symptoms of diabetes mellitus manifest, once pancreatic β-cell numbers have become inadequate. Although natural regeneration β-cells after injury is very limited, bone marrow (BM) transplantation (BMT) promotes their through undetermined mechanism(s) involving inter-cellular (BM cell-to-β-cell) crosstalk. We found that two microRNAs (miRNAs) contribute to BMT-induced regeneration. Screening murine miRNAs in serum exosomes BMT revealed 42 be increased. Two these (miR-106b-5p and...
Insulin signals, via the regulation of key enzyme expression, both suppress gluconeogenesis and enhance lipid synthesis in liver. Animal studies have revealed insulin signaling favoring suppression to be selectively impaired steatotic livers. However, whether, if so how, such selective resistance occurs human livers remains unknown. Our aim was investigate with non-alcoholic fatty liver disease (NAFLD). We examined mRNA expressions molecules for signaling, lipogenesis biopsy samples obtained...
The liver possesses a high regenerative capacity. Liver regeneration is compensatory response overcoming disturbances of whole-body homeostasis provoked by organ defects. Here we show that vagus-macrophage-hepatocyte link regulates acute after injury and this system critical for promoting survival. Hepatic Foxm1 rapidly upregulated partial hepatectomy (PHx). branch vagotomy (HV) suppresses upregulation hepatocyte proliferation, thereby increasing mortality. In addition, hepatic FoxM1...
Although apolipoprotein E (apoE) is well known to play a major role in lipid metabolism, its glucose and energy homeostasis remains unclear. Herein, we established apoE-deficient genetically obese Ay (apoE−/−;Ay/+) mice. ApoE deficiency mice prevented the development of obesity, with decreased fat accumulation liver adipose tissues. ApoE−/−;Ay/+ exhibited better tolerance than apoE+/+;Ay/+ Insulin testing hyperinsulinemic-euglycemic clamp study revealed marked improvement insulin...
Angiography of small hepatocellular carcinomas: analysis 105 resected tumorsK Takayasu, Y Shima, Muramatsu, H Goto, N Moriyama, T Yamada, M Makuuchi, S Yamasaki, Hasegawa, Okazaki and al. etAudio Available | Share
There is controversy regarding the roles of bone marrow (BM)-derived cells in pancreatic beta-cell regeneration. To examine these vivo, mice were treated with streptozotocin (STZ), followed by transplantation (BMT; lethal irradiation and subsequent BM cell infusion) from green fluorescence protein transgenic mice. BMT improved STZ-induced hyperglycemia, nearly normalizing glucose levels, partially restored islet number size, whereas simple infusion without preirradiation had no effects. In...
Interleukin-6 (IL-6) has a significant impact on glucose metabolism. However, the effects of IL-6 insulin secretion from pancreatic β-cells are controversial. Therefore, we analyzed β-cell functions both in vivo and vitro.First, to examine secretion, expressed livers mice using adenoviral gene transfer system. In addition, MIN-6 cells, murine line, islets isolated mice, vitro pretreatment secretion. Furthermore, pharmacological inhibitors small interfering RNAs, studied intracellular...
Vascular remodelling and aortic aneurysm formation are induced mainly by inflammatory responses in the adventitia media. However, relatively little is known about mechanistic significance of endothelium pathogenesis these vascular disorders. The transcription factor nuclear factor-kappa B (NF-κB) regulates expressions numerous genes, including those related to pro-inflammatory responses. Therefore, investigate roles endothelial responses, we examined impact blocking NF-κB signalling on...