A5079978258- Lipid metabolism and disorders
- Cancer, Hypoxia, and Metabolism
- Cancer, Lipids, and Metabolism
- Cancer-related molecular mechanisms research
- Adipose Tissue and Metabolism
- Angiogenesis and VEGF in Cancer
- RNA modifications and cancer
- Adipokines, Inflammation, and Metabolic Diseases
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Atherosclerosis and Cardiovascular Diseases
- Nail Diseases and Treatments
- Cardiovascular Function and Risk Factors
- Mitochondrial Function and Pathology
- Apelin-related biomedical research
- Drug-Induced Hepatotoxicity and Protection
- Peroxisome Proliferator-Activated Receptors
- Pharmacogenetics and Drug Metabolism
- Exercise and Physiological Responses
- Antifungal resistance and susceptibility
- Liver Disease Diagnosis and Treatment
- Autophagy in Disease and Therapy
- Pancreatic function and diabetes
- Inflammatory mediators and NSAID effects
- Endoplasmic Reticulum Stress and Disease
- Genetics and Neurodevelopmental Disorders
Kumamoto University
2016-2025
Kumamoto Health Science University
2019
RELX Group (United States)
2016
Japan Science and Technology Agency
2008-2014
Hyogo Medical University
2012-2014
Kyushu University
2014
The University of Tokyo
2012-2014
Keio University
2003-2014
Tohoku University
2013
Hamamatsu University School of Medicine
2013
To elucidate whether and how the endoplasmic reticulum (ER) stress-C/EBP homologous protein (CHOP) pathway in macrophages is involved rupture of atherosclerotic plaques.Increases macrophage-derived foam cell death coronary plaques cause plaque to become vulnerable, thus resulting acute syndrome. The ER stress-CHOP/growth arrest DNA damage-inducible gene-153 (GADD153) induced cells lesions formation. However, role CHOP final stage atherosclerosis has not been fully elucidated. Many...
Cannabinoid 1 (CB1) receptor blockade with rimonabant represents a clinical therapeutic strategy for obesity. Recently, the role of endocannabinoid system has been described in peripheral organs. We sought to determine whether could be involved human atherosclerosis and CB1 modulate proinflammatory activity macrophages.mRNA expression levels coronary atherectomy samples were significantly higher patients unstable angina than those stable (3.62+/-2.96-fold; n=7; P<0.05). Immunoreactive area...
Objective— Cardiovascular disease (CVD), the most common morbidity resulting from atherosclerosis, remains a frequent cause of death. Efforts to develop effective therapeutic strategies have focused on vascular inflammation as critical pathology driving atherosclerosis progression. Nonetheless, molecular mechanisms underlying this activity remain unclear. Here, we ask whether angiopoietin-like protein 2 (Angptl2), proinflammatory protein, contributes that promotes Approach and Results—...
Chronic inflammation plays important roles at different stages of cancer development, including carcinogenesis, tumor invasion, and metastasis, but molecular mechanisms linking to development have not been fully clarified. Here, we report that expression angiopoietin-like protein 2 (Angptl2), recently identified as a chronic mediator, is highly correlated with the frequency carcinogenesis in chemically induced skin squamous cell carcinoma (SCC) mouse model. Furthermore, Angptl2 SCC...
Strategies to inhibit metastasis have been mainly unsuccessful in part due insufficient mechanistic understanding. Here, we report evidence of critical role for the angiopoietin-like protein 2 (ANGPTL2) metastatic progression. In mice, Angptl2 has implicated inflammatory carcinogenesis but it not studied human tumors. patients with lung cancer, elevated levels ANGPTL2 expression tumor cells within primary were associated a reduction period disease-free survival after surgical resection....
Skeletal muscle has a pleiotropic role in organismal energy metabolism, for example, by storing protein as an source, or excreting endocrine hormones. Muscle proteolysis is tightly controlled the hypothalamus-pituitary-adrenal signalling axis via glucocorticoid-driven transcriptional programme. Here we unravel physiological significance of this catabolic process using skeletal muscle-specific glucocorticoid receptor (GR) knockout (GRmKO) mice. These mice have increased mass but smaller...
Preventing signaling by ANGPTL2, which is stimulated the tumor microenvironment, could inhibit metastasis.
A subset of mitochondrial tRNAs (mt-tRNAs) contains taurine-derived modifications at 34U the anticodon. Loss taurine modification has been linked to development diseases, but molecular mechanism is still unclear. Here, we showed that catalyzed by optimization 1 (Mto1) in mammals. Mto1 deficiency severely impaired translation and respiratory activity. Moreover, Mto1-deficient cells exhibited abnormal morphology owing aberrant trafficking nuclear DNA-encoded proteins, including Opa1. The...
Sarcopenia due to loss of skeletal muscle mass and strength leads physical inactivity decreased quality life. The number individuals with sarcopenia is rapidly increasing as the older people increases worldwide, making this condition a medical social problem. Some patients exhibit accumulation peri-muscular adipose tissue (PMAT) ectopic fat deposition surrounding atrophied muscle. However, an association PMAT atrophy has not been demonstrated. Here, we show that associated in aged mice...
Abstract In the past decade, many long noncoding RNAs (lncRNAs) have been identified and their in vitro functions defined, although some cases vivo remain less clear. Moreover, unlike nuclear lncRNAs, roles of cytoplasmic lncRNAs are defined. Here, using a gene trapping approach mouse embryonic stem cells, we identify Caren (short for cardiomyocyte-enriched transcript), lncRNA abundantly expressed cardiomyocytes. maintains cardiac function under pathological stress by inactivating ataxia...
Objective— Recently, we reported that angiopoietin-like protein 2 (Angptl2) functions in various chronic inflammatory diseases. In the present study, asked whether Angptl2 and its associated inflammation contribute to abdominal aortic aneurysm (AAA). Methods Results— Immunohistochemistry revealed is abundantly expressed infiltrating macrophages within vessel wall of patients with AAA a CaCl -induced mouse model. When Angptl2-deficient mice were used model, they showed decreased development...
Abstract Xp11.2 translocation renal cell carcinoma (Xp11 tRCC ) is a rare sporadic pediatric kidney cancer caused by constitutively active TFE 3 fusion proteins. Tumors in patients with Xp11 tend to recur and undergo frequent metastasis, part due lack of methods available detect early‐stage disease. Here we generated transgenic (Tg) mice overexpressing the human PRCC ‐ gene tubular epithelial cells, as an mouse model. At 20 weeks age, showed no histological abnormalities but 40 development...
Invariant natural killer T (iNKT) cells are a group of innate-like lymphocytes that recognize lipid antigens. They supposed to be tissue resident and important for systemic local immune regulation. To investigate the heterogeneity iNKT cells, we recharacterized in thymus peripheral tissues. were divided into three subpopulations by expression cell receptor CD244 chemokine CXCR6 designated as C0 (CD244-CXCR6-), C1 (CD244-CXCR6+), or C2 (CD244+CXCR6+) cells. The development maturation from...