A5049895325- Hormonal Regulation and Hypertension
- Nitric Oxide and Endothelin Effects
- Cardiac Imaging and Diagnostics
- Antiplatelet Therapy and Cardiovascular Diseases
- Heart Failure Treatment and Management
- Cardiovascular Function and Risk Factors
- Diabetes Treatment and Management
- Renin-Angiotensin System Studies
- Lipoproteins and Cardiovascular Health
- Blood Pressure and Hypertension Studies
- GaN-based semiconductor devices and materials
- Cardiac electrophysiology and arrhythmias
- Inflammatory mediators and NSAID effects
- Cardiovascular Disease and Adiposity
- Semiconductor Quantum Structures and Devices
- Atrial Fibrillation Management and Outcomes
- Coronary Interventions and Diagnostics
- Eicosanoids and Hypertension Pharmacology
- Advanced MRI Techniques and Applications
- Peptidase Inhibition and Analysis
- Liver Disease Diagnosis and Treatment
- Cardiovascular Health and Risk Factors
- Ion Transport and Channel Regulation
- Cancer, Lipids, and Metabolism
- Synthesis of Organic Compounds
Yokohama City University
2020-2024
Yokohama City University Hospital
2023-2024
Tower Semiconductor (Israel)
2024
Minamiaoyama Eye Clinic
2012-2023
Waseda University
2023
Tel Aviv University
2022
Gifu Heart Center
2022
Rabin Medical Center
2022
Tokyo Medical University
2012-2021
Hiroshima Prefectural Rehabilitation Center
2018-2019
Coronary spasm plays an important role in the pathogenesis of ischemic heart diseases general. However, precise mechanism(s) responsible for coronary remains to be elucidated, and we examined molecular genetics spasm.We searched possible mutations endothelial nitric oxide synthase (eNOS) gene patients with spasm. In this study, demonstrate existence 3 linked 5'-flanking region eNOS (T-786-->C, A-922-->G, T-1468-->A). The incidence was significantly greater than control group (P<0.0001)....
<h3>Context</h3>Previous trials have investigated the effects of low-dose aspirin on primary prevention cardiovascular events, but not in patients with type 2 diabetes.<h3>Objective</h3>To examine efficacy for atherosclerotic events diabetes.<h3>Design, Setting, and Participants</h3>Multicenter, prospective, randomized, open-label, blinded, end-point trial conducted from December 2002 through April 2008 at 163 institutions throughout Japan, which enrolled 2539 diabetes without a history...
Abstract —Essential hypertension has a genetic basis. Accumulating evidence, including findings of elevation arterial blood pressure in mice lacking the endothelial nitric oxide synthase (eNOS) gene, strongly suggests that alteration NO metabolism is implicated hypertension. There are, however, no reports indicating polymorphism eNOS gene associated with essential We have identified missense variant, Glu298Asp, exon 7 and demonstrated it both coronary spastic angina myocardial infarction. To...
Background —Recent reports have indicated that aldosterone is produced in extra-adrenal tissues animals. The present study was designed to examine whether human heart. Methods and Results —Plasma levels of aldosterone, BNP, angiotensin-converting enzyme were measured anterior interventricular vein (AIV), coronary sinus (CS), aortic root (Ao), respectively, 20 patients with left ventricular systolic dysfunction (LVSD), 25 LV diastolic (LVDD), 23 control subjects. Aldosterone significantly...
The cardiac renin-angiotensin-aldosterone system is activated in failing hearts proportion to the severity of disease. We hypothesized that a positive feedback mechanism might exist within this and contribute progression heart failure. Methods Results-- To test hypothesis, we examined whether angiotensin II or aldosterone induces expression angiotensin-converting-enzyme (ACE) mRNA cultured neonatal rat ventricular cardiocytes. Expression ACE was detected quantified using real-time reverse...
Cannabinoid 1 (CB1) receptor blockade with rimonabant represents a clinical therapeutic strategy for obesity. Recently, the role of endocannabinoid system has been described in peripheral organs. We sought to determine whether could be involved human atherosclerosis and CB1 modulate proinflammatory activity macrophages.mRNA expression levels coronary atherectomy samples were significantly higher patients unstable angina than those stable (3.62+/-2.96-fold; n=7; P<0.05). Immunoreactive area...
The long-term efficacy and safety of low-dose aspirin for primary prevention cardiovascular events in patients with type 2 diabetes mellitus are still inconclusive.The JPAD trial (Japanese Primary Prevention Atherosclerosis With Aspirin Diabetes) was a randomized, open-label, standard care-controlled examining whether affected 2539 Japanese without preexisting disease. Patients were randomly allocated to receive (81 or 100 mg daily; group) no (no-aspirin the trial. After that ended 2008, we...
Background— Circulating levels of B-type natriuretic peptide (BNP), a cardiac hormone, reflect the severity dysfunction. Because plasma BNP level changes dramatically during period after onset acute myocardial infarction (AMI), identification suitable sampling time is problematic. There have been several reports indicating that obtained in phase AMI can be used as prognostic marker. We examined whether measured 3 to 4 weeks represents reliable marker for patients with AMI. Methods and...
Background— Coronary spastic angina (CSA) is a common disease among East Asians, including Japanese. The prevalence of alcohol flushing syndrome associated with deficient activity the variant aldehyde dehydrogenase 2 ( ALDH2*2 ) genotype prevalent Asians. We examined whether CSA in Methods and Results— study subjects consisted 202 patients whom intracoronary injection acetylcholine was performed by angiography on suspicion (119 men 83 women; mean age, 66.2±11.4 years). They were divided into...
We have shown that aldosterone, previously thought to be synthesized solely in the adrenal cortex, is also produced failing human heart. One way induce aldosterone synthesis heart would increase expression of CYP11B2, enzyme catalyzing terminal step synthesis. However, CYP11B2 has never been examined cardiac tissue from patients with failure. assayed left ventricular obtained at autopsy seven patients. Total RNA was extracted frozen samples. gene then quantitatively analyzed using a modified...
Although previously thought to be synthesized solely in adrenal cortex, we have recently showed that aldosterone is also produced and the expression of CYP11B2 mRNA was induced failing or hypertensive human ventricle. Atrial natriuretic peptide (ANP) brain (BNP) are cardiac hormones with wide biological effects, including inhibition renin production. We hypothesized peptides reduce heart.To test this hypothesis, examined whether endogenous exogenous using real-time reverse...
This study was designed to examine whether aldosterone is produced from the hearts of patients with essential hypertension without left ventricular systolic dysfunction (LVSD). The population consisted 20 LVSD and 22 control subjects. Plasma levels aldosterone, serum ACE activity, B-type natriuretic peptide were measured in anterior interventricular vein (AIV), coronary sinus, aortic root during cardiac catheterization. plasma significantly higher AIV sinus than (99+/-11 versus 88+/-10...
Aldosterone is produced not only in the adrenal gland but also extra-adrenal tissues, including failing human heart. This study examined production of dehydroepiandrosterone (DHEA) heart and elucidated possible physiological significance. Method Results- Using left ventricular tissues obtained at autopsy, reverse transcription-polymerase chain reaction followed by Southern blot analysis revealed gene expressions CYP17. By measuring plasma aldosterone DHEA levels coronary sinuses aortic roots...
OBJECTIVE Type 2 diabetes accompanied by renal damage is a strong risk factor for atherosclerotic events. The purpose of this study was to investigate the efficacy low-dose aspirin therapy on primary prevention events in patients with type and coexisting dysfunction. RESEARCH DESIGN AND METHODS Japanese Primary Prevention Atherosclerosis With Aspirin Diabetes (JPAD) trial prospective, randomized, open-label conducted throughout Japan that enrolled 2,539 diabetic without history diseases....
Background:The efficacy of sodium-glucose cotransporter 2 (SGLT2) inhibitors in elderly patients with heart failure preserved ejection fraction (HFpEF) remains unclear.