A5001727346- Geological and Geochemical Analysis
- earthquake and tectonic studies
- Geology and Paleoclimatology Research
- High-pressure geophysics and materials
- Particle physics theoretical and experimental studies
- AI in cancer detection
- Total Knee Arthroplasty Outcomes
- MRI in cancer diagnosis
- Orthopaedic implants and arthroplasty
- Paleontology and Stratigraphy of Fossils
- Geological Studies and Exploration
- Methane Hydrates and Related Phenomena
- Knee injuries and reconstruction techniques
- Neutrino Physics Research
- Rheumatoid Arthritis Research and Therapies
- Digital Imaging for Blood Diseases
- Geochemistry and Geologic Mapping
- Geological and Geophysical Studies
- Infrared Thermography in Medicine
- Advanced MRI Techniques and Applications
- Radiomics and Machine Learning in Medical Imaging
- Cardiovascular Function and Risk Factors
- Orthopedic Infections and Treatments
- Dark Matter and Cosmic Phenomena
- Cardiac pacing and defibrillation studies
Saitama Medical University
2015-2024
National Institute for Environmental Studies
2015-2023
Kindai University
1991-2023
Yokohama National University
2010-2023
Saitama Prefecture
2023
Nagahama City Hospital
2023
Social Insurance Saitama Chuo Hospital
2023
Noguchi Hospital
2011-2022
Industrial Research Institute of Ishikawa
2022
Osaka University
1994-2021
We collected and completely sequenced 28,469 full-length complementary DNA clones from Oryza sativa L. ssp. japonica cv. Nipponbare. Through homology searches of publicly available sequence data, we assigned tentative protein functions to 21,596 (75.86%). Mapping the cDNA genomic revealed that there are 19,000 20,500 transcription units in rice genome. Protein informatics analysis against InterPro database existence proteins presented but not Arabidopsis. Sixty-four percent our cDNAs...
Abstract —Essential hypertension has a genetic basis. Accumulating evidence, including findings of elevation arterial blood pressure in mice lacking the endothelial nitric oxide synthase (eNOS) gene, strongly suggests that alteration NO metabolism is implicated hypertension. There are, however, no reports indicating polymorphism eNOS gene associated with essential We have identified missense variant, Glu298Asp, exon 7 and demonstrated it both coronary spastic angina myocardial infarction. To...
Abstract Introduction MicroRNAs (miRNAs), endogenous small noncoding RNAs regulating the activities of target mRNAs and cellular processes, are present in human plasma a stable form. In this study, we investigated whether miRNAs also stably synovial fluids fluid could be biomarkers rheumatoid arthritis (RA) osteoarthritis (OA). Methods We measured concentrations miR-16, miR-132, miR-146a, miR-155 miR-223 from patients with RA OA, those RA, OA healthy controls (HCs) by quantitative reverse...
A bstract The OPERA neutrino experiment is designed to perform the first observation of oscillations in direct appearance mode ν μ → τ channel, via detection -leptons created charged current interactions. detector, located underground Gran Sasso Laboratory, consists an emulsion/lead target with average mass about 1.2 kt, complemented by electronic detectors. It exposed CERN Neutrinos beam, a baseline 730 km and mean energy 17 GeV. candidate event analysis 2008-2009 sample have been reported...
Abstract Background Protection from lethal ventricular arrhythmias leading to sudden cardiac death (SCD) is a crucial challenge after acute myocardial infarction (AMI). Cardiac sympathetic and parasympathetic activity can be noninvasively assessed using heart rate variability (HRV) turbulence (HRT). The EMBODY trial was designed determine whether the Sodium–glucose cotransporter 2 (SGLT2) inhibitor improves nerve activity. Methods This prospective, multicenter, randomized, double-blind,...
Abstract Coesite relics were discovered as inclusions in clinopyroxene eclogite and zircon felsic pelitic gneisses from Higher Himalayan Crystalline rocks the upper Kaghan Valley, north‐west Himalaya. The metamorphic peak conditions of coesite‐bearing eclogites are estimated to be 27–32 kbar 700–770 °C, using garnet–pyroxene–phengite geobarometry garnet–pyroxene geothermometry, respectively. Cathodoluminescence (CL) backscattered electron (BSE) imaging distinguished three different domains...
MicroRNAs (miRNAs) are present in human plasma and known as a non-invasive biomarker for cancer detection. Our study was designed to identify miRNAs specific rheumatoid arthritis (RA) by comprehensive array approach. We performed systematic, array-based miRNA analysis on samples from three RA patients healthy controls (HCs). Plasma with more than four times change or significant (P<0.05) expression, detectable only plasma, were confirmed eight HCs using real-time quantitative PCR....
MicroRNAs (miRNAs) are endogenous small noncoding RNAs that regulate the activity of target messenger (mRNAs) and cellular processes. MicroRNA-451 (miR-451) is one miRNAs conserved perfectly among vertebrates, it regulates cell proliferation, invasion, apoptosis in tumors. However, role miR-451 autoimmune arthritis unknown. This study was undertaken to identify arthritis.We compared expression neutrophils from patients with rheumatoid (RA) healthy controls. We also evaluated neutrophil...
ABSTRACT MicroRNAs (miRNAs) are endogenous small noncoding RNAs regulating the activities of target mRNAs and cellular processes. Although no miRNA has been reported to play an important role in regulation fracture healing, several miRNAs control key elements tissue repair processes such as inflammation, hypoxia response, angiogenesis, stem cell differentiation, osteogenesis, chondrogenesis. We compared plasma concentrations 134 4 patients with trochanteric fractures healthy controls (HCs),...
Plants have developed several strategies for coping with phosphorus (P) deficiency. However, the details of regulation gene expression adaptations to low P are still unclear. Using a cDNA microarray, transcriptomic analyses were carried out rice genes regulated by deficiency and re-supply P-deficient plants. The OsPI1 gene, which was isolated as most significant up-regulated under –P conditions, also down-regulated following re-supply. Many starch metabolism-related genes, well Pi-liberating...
Oxidative stress may underlie age-dependent memory loss and cognitive decline. Toxic aldehydes, including 4-hydroxy-2-nonenal (HNE), an end product of lipid peroxides, are known to accumulate in the brain neurodegenerative disease. We have previously shown that mitochondrial aldehyde dehydrogenase 2 (ALDH2) detoxifies HNE by oxidizing its group. To investigate role such toxic we produced transgenic mice, which expressed a dominant-negative form ALDH2 brain. The mice had decreased ability...
The OPERA experiment is designed to search for ${\ensuremath{\nu}}_{\ensuremath{\mu}}\ensuremath{\rightarrow}{\ensuremath{\nu}}_{\ensuremath{\tau}}$ oscillations in appearance mode, i.e., through the direct observation of $\ensuremath{\tau}$ lepton ${\ensuremath{\nu}}_{\ensuremath{\tau}}$-charged current interactions. has taken data five years, since 2008, with CERN Neutrino Gran Sasso beam. Previously, two ${\ensuremath{\nu}}_{\ensuremath{\tau}}$ candidates a decaying into hadrons were...
A subset of CD4+ T cells in the synovium patients with rheumatoid arthritis (RA) produce CXCL13, a chemokine that is crucial for formation germinal centers. This study was undertaken to determine relevance this population known subsets helper and proinflammatory cytokines, how these are generated.The expression Th markers CXCL13 by RA involvement cytokines production were assessed. We also investigated whether CXCL13+CD4+ could be newly induced.CXCL13+CD4+ negative interferon-γ (IFNγ),...
Objective The purpose of this study was to investigate chemokine profiles and their functional roles in the early phase fracture healing mouse models. Methods expression chemokines were examined during wild-type (WT) mice using a polymerase chain reaction array histological staining. effect monocyte chemotactic protein-1 (MCP-1) on primary bone marrow stromal cells (mBMSCs) evaluated an vitro migration assay. MCP-1−/− C-C receptor 2 (CCR2)−/− fractured by staining micro-computed tomography...
Malrotation of the tibial component can lead to complications after total knee arthroplasty (TKA). Despite reports internal rotation being associated with more severe pain or stiffness than external rotation, biomechanical reasons remain largely unknown. We used a computer simulation model and evaluated traction forces in lateral collateral ligament (LCL) medial (MCL) malrotated during squatting. also examined tibiofemoral patellofemoral contact stresses under similar conditions. A dynamic...
Abstract We review the evolution of late Cenozoic magmatism in NE Japan arc, and examine relationship between crust–mantle structure. Recent studies reveal secular changes mode magmatic activity, magma plumbing system, erupted volumes composition associated with structures related to tectonic arc. The arc can be divided into three periods: continental margin (66–21 Ma), back-arc basin (21–13.5 Ma) island-arc period (13.5–0 Ma). Magmatic periods appears 2D 3D change convection pattern mantle...
While silicon nitride (Si3 N4 ) is an antimicrobial and osseointegrative orthopaedic biomaterial, the contribution of surface topography to these properties unknown. Using a methicillin-resistant strain Staphylococcus aureus (MRSA), this study evaluated Si3 implants in vitro utilizing scanning electron microscopy (SEM) with colony forming unit (CFU) assays, later established vivo murine tibia model implant-associated osteomyelitis. In vitro, "as-fired" displayed significant reductions...
The mechanism responsible for cardiac hypertrophy is currently conceptualized as having 2 components, mediated by myocytes and nonmyocytes, respectively. interaction between nonmyocytes via growth factors and/or cytokines plays an important role in the development of hypertrophy. We found that showed hypertrophic changes when cocultured with nonmyocytes. Cardiotrophin-1 (CT-1), a new member interleukin-6 family cytokines, was identified its ability to induce response myocytes. In this study,...
Abstract Ultrahigh‐pressure metamorphic (UHPM) rocks of the Kokchetav Massif Kazakhstan contain microdiamond and coesite inclusions inside rigid capsules such as garnet zircon. Precambrian protoliths UHPM were metamorphosed at around 530 Ma, pressures about 7 GPa, which suggests that crustal subducted to depths over 200 km. Primary minerals are poorly preserved due partial obliteration by subsequent Barrovian overprint during exhumation later collision events in Caledonian times. We report...