A5101903674- Mitochondrial Function and Pathology
- Metabolism and Genetic Disorders
- RNA modifications and cancer
- Alcohol Consumption and Health Effects
- Diet and metabolism studies
- Liver Disease Diagnosis and Treatment
- Cardiovascular Function and Risk Factors
- Cancer, Hypoxia, and Metabolism
- ATP Synthase and ATPases Research
- Diabetes Treatment and Management
- Neuropeptides and Animal Physiology
- Peroxisome Proliferator-Activated Receptors
- dental development and anomalies
- Adipose Tissue and Metabolism
- Lung Cancer Treatments and Mutations
- Pancreatic function and diabetes
- Adipokines, Inflammation, and Metabolic Diseases
- Biochemical effects in animals
- RNA and protein synthesis mechanisms
- Lung Cancer Research Studies
- Pain Mechanisms and Treatments
- Alcoholism and Thiamine Deficiency
- Cancer-related molecular mechanisms research
- Diabetes and associated disorders
- Metabolism, Diabetes, and Cancer
Teikyo University
1994-2016
Tokyo Medical Center
2013-2015
National Hospital Organization
2004-2015
Nippon Medical School
2003-2014
Japan Advanced Institute of Science and Technology
2012-2013
Azabu University
2001-2011
National Hospital Organization Takasaki Medical Center
1995-2010
University of Miyazaki
2003-2010
Nishijin Hospital
2009
Matsudo City Hospital
2003-2008
Several families have been described in which a mutation of mitochondrial DNA, the substitution guanine for adenine (A-->G) at position 3243 leucine transfer RNA, is associated with diabetes mellitus and deafness. The prevalence, clinical features, pathophysiology this are largely undefined.We studied 55 patients insulin-dependent (IDDM) family history (group 1), 85 IDDM no 2), 100 non-insulin-dependent (NIDDM) 3), 5 deafness 4) mutation. We also prevalence characteristics 39 syndrome...
Oxidative stress may underlie age-dependent memory loss and cognitive decline. Toxic aldehydes, including 4-hydroxy-2-nonenal (HNE), an end product of lipid peroxides, are known to accumulate in the brain neurodegenerative disease. We have previously shown that mitochondrial aldehyde dehydrogenase 2 (ALDH2) detoxifies HNE by oxidizing its group. To investigate role such toxic we produced transgenic mice, which expressed a dominant-negative form ALDH2 brain. The mice had decreased ability...
Objective Intestinal ischemia-reperfusion after severe shock states is often associated with bacterial translocation and intestinal barrier dysfunction. Our previous studies showed that inducible nitric oxide synthase (iNOS) gene knockout mice were resistant to endotoxin-induced ileal mucosal damage. The goal of this study was test whether iNOS mediates ischemia-reperfusion, using (iNOS−/−) their wild-type littermates (iNOS+/+). Design Prospective animal concurrent controls. Setting Small...
The major side-effect of treatment with alpha-glucosidase inhibitors, flatulence, occurs when undigested carbohydrates are fermented by colonic bacteria, resulting in gas formation. We propose that the cardiovascular benefits inhibitors partly attributable to their ability neutralise oxidative stress via increased production H(2) gastrointestinal tract. Acarbose, which is an inhibitor, markedly production, a weaker effect on methane production. Our hypothesis based our recent discovery acts...
pAkt/Glioblastoma/Radiation therapy.phosphorylated-Akt (pAkt) plays an important role in tumorigenesis through promotion of cell survival by inhibiting apoptosis and mediating proliferation.Higher expression pAkt has been reported to be associated with unfavorable prognosis several malignant tumors.In this study, the prognostic value was investigated glioblastomas using immunohistochemical methods.Tissue sections obtained from 64 patients glioblastoma were evaluated.The mean median follow-up...
OBJECTIVE To present a novel mitochondrial DNA mutation in diabetic family RESEARCH DESIGN AND METHODS The proband was 64-year-old man. In the family, diabetes maternally inherited. He had diabetes, cerebellar ataxia, cervical lipoma, hearing loss, olfactory dysfunction, ophthalmoplegia, and facial nerve bilateral palsy. On examination, early insulin secretion blunted, M value on glucose clamp test low. muscle, ragged red fibers were not found. T-to-C at position 3264 detected (0.5% mutant...
The apricot variety in Japan is "Prunus mume Sieb. et Zucc" (Ume). Japanese have been growing Ume tree for more than 2000 years because of its health enhancing effects, and through cultivation, they improved the to produce healthier fruits. purpose this study was investigate presence anti-cancer substances Ume. One kg squeezed separate soft fruit from seed capsules. fraction boiled at 90°C 100°C obtain 20 g semi-solid (misatol). condensed dissolved a water-diethylether. diethylether dried...
Oxidative stress is involved in age-related muscle atrophy, such as sarcopenia. Since Chlorella, a unicellular green alga, contains various antioxidant substances, we used mouse model of enhanced oxidative to investigate whether Chlorella could prevent atrophy. Aldehyde dehydrogenase 2 (ALDH2) an anti-oxidative enzyme that detoxifies reactive aldehydes derived from lipid peroxides 4-hydroxy-2-nonenal (4-HNE). We therefore transgenic mice expressing dominant-negative form ALDH2 (ALDH2*2 Tg...
To investigate the prevalence and clinical characteristics of diabetes mellitus caused by mitochondrial gene mutations in tRNALeu(UUR) region, a known 'hot spot' for pathogenic mutations, we screened 440 diabetic patients with mothers 11 reported neuromuscular disorders; nucleotide pairs (np) 3250, 3251, 3252, 3254, 3256, 3260, 3271, 3291, 3302 3303 addition to an A G transition at np 3243. The dot-blot hybridization method using 32P-labelled sequence-specific oligonucleotides as probes was...
Article: Presented At The 57Th Annual Meeting Of American Association For Surgery Trauma And Japanese Acute Medicine, September 24-27, 1997, Waikoloa, Hawaii
Optimal timing of the measurement serum squamous cell carcinoma (SCC) antigen during radiation therapy (RT) and its significance for predicting response cervical patients as early possible remain unknown.Sixty-three with SCC uterine cervix who received RT only were studied. Patients treated a combination external beam irradiation high-dose rate intracavitary irradiation. The level was measured before, every 2 or 3 weeks during, 1 months after RT. Clinical outcome divided into complete...