A5070071795- Endometrial and Cervical Cancer Treatments
- Glioma Diagnosis and Treatment
- Radiation Therapy and Dosimetry
- Advanced X-ray and CT Imaging
- Advanced Radiotherapy Techniques
- Radiation Detection and Scintillator Technologies
- Wound Healing and Treatments
- Effects of Radiation Exposure
- Cancer-related Molecular Pathways
- Neurogenesis and neuroplasticity mechanisms
- Neuroscience and Neuropharmacology Research
- Management of metastatic bone disease
- Cancer, Hypoxia, and Metabolism
- Radiation Dose and Imaging
- Colorectal and Anal Carcinomas
- Medical Imaging Techniques and Applications
- Radioactive contamination and transfer
- Lymphoma Diagnosis and Treatment
- Cervical Cancer and HPV Research
- Brain Metastases and Treatment
- Immunotherapy and Immune Responses
- Radioactivity and Radon Measurements
- Advanced Semiconductor Detectors and Materials
- Cancer Immunotherapy and Biomarkers
- Mesenchymal stem cell research
Kyoto University
1995-2025
Tokyo Dental College
2025
Gunma University
2011-2023
National Institutes for Quantum Science and Technology
1999-2023
Kyoto University of Education
2023
Nagoya University
2022
Creative Commons
2022
Gunma University Hospital
2010-2020
Japan Atomic Energy Agency
2016
Fukushima Medical University
2016
Purpose There is growing evidence that tumor-specific immune responses play an important role in anti-cancer therapy, including radiotherapy. Using mouse tumor models we demonstrate irradiation-induced anti-tumor immunity essential for the therapeutic efficacy of irradiation and can be augmented by modulation cytotoxic T lymphocyte (CTL) activity. Methods Materials C57BL/6 mice, syngeneic EL4 lymphoma cells, Lewis lung carcinoma (LL/C) cells were used. Cells injected into right femurs mice....
Retrospective analysis was performed on 1022 patients with squamous cell carcinoma of the uterine cervix who were treated high-dose-rate remote afterloading intracavitary irradiation at National Institute Radiological Sciences, Angawa, Chiba-shi, Japan, from 1968 to 1982 in comparison low-dose-rate radiation therapy. The patient population consisted 147 Stage I disease, 256 II 515 III and 104 IV disease. Absolute 5-year survival rates for Stages Ib, IIa, IIb, IIIb, IVa, IVb disease 88.1%,...
We have examined the immunoregulatory effect of local and continuous secretion interleukin 7 (IL-7) from murine glioma cells (203-glioma) engineered by IL-7 gene transfection. Secretion did not result in morphology or growth rate changes but reduce tumorigenicity vivo proportion to amount produced. This reduction could be reversed a dose-dependent fashion injection anti-IL-7 neutralizing monoclonal antibody at tumor site. Mice immunized with IL-7-producing showed specific immune response...
Abstract Herein, we investigate the long-term clinical outcomes for cervical cancer patients treated with in-room computed tomography–based brachytherapy. Eighty Stage IB1–IVA cancer, who had undergone treatment combined 3D high-dose rate brachytherapy and conformal radiotherapy between October 2008 May 2011, were retrospectively analyzed. External beam (50 Gy) central shielding after 20–40 Gy was performed each patient. Cisplatin-based chemotherapy administered concurrently to...
This study was conducted to investigate the feasibility and survival benefits of combined treatment with radiotherapy temozolomide (TMZ), which has been covered by national health insurance in Japanese patients glioblastoma since September 2006. Between 2006 December 2011, 47 newly diagnosed histologically confirmed received for 60 Gy 30 fractions. Among them, 45 (TMZ group) concomitant TMZ (75 mg/m2/day, every day) adjuvant (200 5 days during each 28-days). All 36 receiving between January...
Migraine-like features sometimes characterize the headache that follows epileptic seizure (postictal headache, PIH). We compared patients with different types of epilepsy to investigate association between migraine-like PIH and type. Subjects comprised 364 partial epilepsy. Epilepsy were temporal lobe (TLE, n = 177), frontal (FLE, 116), occipital (OLE, 71). Patients participated in a structured interview pertaining as well interictal family history migraine. Headaches classified according...
Versatile and conveniently operated microreactor devices, suitable for long term chemical synthesis both laboratory industrial use, are described. Direct fluorination of ethyl acetoacetate by fluorine gas is used as a model reaction to illustrate the successful application reactors having either 9, 18 or 30 microchannels, with all channels supplied from single reagent sources, provide significant quantities fluorinated products. Convenient reactor maintenance, simple design, versatility...
Journal Article Raman diagnosis of nucleic acid structure: sugar-puckering and glycosidic conformation in the guanosine moiety Get access Yoshifumi Nishimura, Nishimura Faculty Pharamaceutical Sciences *University TokyoHongo, Bunkyo-ku Search for other works by this author on: Oxford Academic PubMed Google Scholar Masamichi Tsuboi, Tsuboi Toru Nakano, Nakano +Mitsubishi-Kasei Institute Life Science11 Minamiooya, Machida, Tokyo, Japan Shigesada Higuchi, Higuchi Tomohiro Sato, Sato Toshio...
Breast milk is considered to be the best nutrient source for infants. However, nutritional compositions of breast in developing countries, especially among malnourished women, have not been fully investigated. This study aimed assess status and composition lactating mothers rural Vietnam. Sixty breastfeeding at 6 12 mo postpartum, free from any medical disorder and/or medication, pregnant were randomly selected Yen The, Bac Giang, Their status, concentration dietary intakes assessed. Among...
To develop more effective therapies for patients with advanced gastric cancer, we examined the potential of ex vivo expanded natural killer (NK) cells. We assessed expression ligands NK Group 2 Member D (NKG2D, an important activation molecule) in primary tumors from 102 cancer by immunohistochemistry and determined their prognostic value. then vitro cytotoxicity cells healthy donors cancer. The resting interleukin (IL)‐2‐activated was compared to that 7 days coculture K562‐mb15‐4.1BBL cell...
In order to discriminate between malignant and benign effusions, the values of carcinoembryonic antigen (CEA), ferritin, beta2-microglobulin (BMG), acid-soluble glycoprotein (ASP), tissue polypeptide (TPA), adenosine deaminase (ADA), immunosuppressive acidic protein (IAP) were measured in pleural fluid 54 patients with lung cancer, 20 malignancies other than 18 tuberculous pleurisy, 22 diseases tuberculosis. CEA levels effusions significantly higher those effusions. At a cutoff level 5...
pAkt/Glioblastoma/Radiation therapy.phosphorylated-Akt (pAkt) plays an important role in tumorigenesis through promotion of cell survival by inhibiting apoptosis and mediating proliferation.Higher expression pAkt has been reported to be associated with unfavorable prognosis several malignant tumors.In this study, the prognostic value was investigated glioblastomas using immunohistochemical methods.Tissue sections obtained from 64 patients glioblastoma were evaluated.The mean median follow-up...
We report a new technique of brachytherapy consisting intracavitary combined with computed tomography (CT)-guided interstitial for locally advanced cervical cancer. A Fletcher-Suit applicator and trocar point needles were used performing high-dose rate under in-room CT guidance. First, tandem ovoids implanted into the patient's vagina uterus by conventional method. Based on clinical examination MRI/CT imaging, operating radiation oncologists decided positions insertion in tumor depth from...
Adipose tissue engineering requires effective strategies for regenerating adipose tissue, with adipose-derived stem cells (ASCs) being favored due to their robust self-renewal capacity and multipotent differentiation potential. In this study, the efficacy of poly-L-lactic acid (PLLA) mesh containing collagen sponge (CS), seeded ASCs promote formation, was investigated. PLLA-CS implants GFP-positive were inserted at high concentration (1 × 10
The objective of this study is to investigate the effects n-butylboronic acid (n-BA) on proliferative activity, alkaline phosphatase expression hard tissue formation related genes, ALP and GJA1 , boron transporter gene, NaBC1 in human dental pulp cells. Human cells were spread culture medium with n-BA. activity was increased n-BA group. staining alizarin red S identified no obvious differences between n-BA(+) n-BA(−) groups. Alkaline significantly group compared Expressions higher than that...