A5100674449- Mesenchymal stem cell research
- Inflammatory Bowel Disease
- Food Quality and Safety Studies
- Microscopic Colitis
- Diverse Approaches in Healthcare and Education Studies
- Plant Physiology and Cultivation Studies
- HIV, Drug Use, Sexual Risk
- Health and Wellbeing Research
- Agriculture, Soil, Plant Science
- Sleep and related disorders
- Tissue Engineering and Regenerative Medicine
- Adipose Tissue and Metabolism
- Allergic Rhinitis and Sensitization
- Heat shock proteins research
- Obstructive Sleep Apnea Research
- Opioid Use Disorder Treatment
- Reconstructive Surgery and Microvascular Techniques
- Hematopoietic Stem Cell Transplantation
- Diet and metabolism studies
- Liver Disease Diagnosis and Treatment
- HIV/AIDS Research and Interventions
- Asthma and respiratory diseases
- Thallium and Germanium Studies
- Immune Cell Function and Interaction
- Immune Response and Inflammation
Kyoto University
2020-2025
University of Ulsan
2017-2024
Ulsan College
2017-2024
Asan Medical Center
2017-2024
Seoul National University Bundang Hospital
2023
Korea National Institute of Health
2018-2022
Seoul National University
2008-2022
Korea Disease Control and Prevention Agency
2018-2022
Seoul National University Hospital
2021
University of Michigan
2014-2020
Preeclampsia is one of the leading causes maternal and fetal morbidity mortality. Due to lack effective preventive measures, its prediction essential prompt management. This study aimed develop models using machine learning predict late-onset preeclampsia hospital electronic medical record data. The performance based conventional statistical methods were also compared. A total 11,006 pregnant women who received antenatal care at Yonsei University Hospital included. Maternal data retrieved...
Abstract Myeloid-derived suppressor cells (MDSCs) are heterogenous populations of immature myeloid progenitor with immunoregulatory function. MDSCs play critical roles in controlling the processes autoimmunity but their rheumatoid arthritis (RA) controversial. The present study was undertaken to investigate whether have therapeutic impact mice collagen-induced (CIA), an animal model RA. We also examined mechanisms underlying anti-arthritic effect MDSCs. In vitro treatment repressed IL-17...
This study was undertaken to assess the effect of myeloid-derived suppressor cells (MDSCs) on various B cell subsets, including regulatory cells, as well potential therapeutic effects MDSC infusion in an animal model systemic lupus erythematosus (SLE).Splenocytes were cultured with MDSCs, and populations effector T subsets analyzed by flow cytometry. Lupus mice (roquinsan/san mice) treated intravenously MDSCs obtained from C57BL/6 mice, levels serum autoantibodies, degree proteinuria,...
Mesenchymal stem cells (MSCs) are multipotent characterized by immunomodulatory properties and therefore considered a promising tool for the treatment of autoimmune diseases. One functional B-cell subset, regulatory B (Bregs), has recently been shown to restrain excessive inflammatory responses in In present study, we investigated impact human adipose-derived MSCs on Bregs their therapeutic effect an animal model systemic lupus erythematosus (SLE). Coculture with splenocytes from C57BL/6...
Both carotid-femoral (cf) pulse wave velocity (PWV) and brachial-ankle (ba) PWV employ arterial sites that are not consistent with the path of blood flow. Few previous studies have reported differential characteristics between cfPWV baPWV by simultaneously comparing these measures pure central (aorta) peripheral (leg) stiffness, i.e., heart-femoral (hf) femoral-ankle (fa) in healthy populations. We aimed to identify degree which commonly used correlate hfPWV faPWV, respectively, evaluate...
Abstract Introduction Mesenchymal stem cells (MSCs) can protect bone marrow transplantation (BMT) recipients from the lethal acute graft-versus-host disease (aGVHD) development. However, mechanisms underlying anti-inflammatory properties of MSCs in aGVHD remain to be elucidated. The immunoregulatory are mediated by their production molecules, including IL-10 and TGF-β. On other hand, also produce proinflammatory cytokines during normal growth, such as IL-1β IL-6. These opposite actions may...
Adipose tissue engineering requires effective strategies for regenerating adipose tissue, with adipose-derived stem cells (ASCs) being favored due to their robust self-renewal capacity and multipotent differentiation potential. In this study, the efficacy of poly-L-lactic acid (PLLA) mesh containing collagen sponge (CS), seeded ASCs promote formation, was investigated. PLLA-CS implants GFP-positive were inserted at high concentration (1 × 10
Background In this study we examined the in vivo and vitro effects mechanisms of action curcumin on development acute graft-versus-host disease (GVHD) using a murine model. Methodology/Principal Findings Mixed lymphocyte reactions were used to determine curcumin. Treatment with attenuated alloreactive T cell proliferation inhibited production interferon (IFN)-γ interleukin (IL)-17. GVHD model, transplantation curcumin-treated allogeneic splenocytes into irradiated recipient mice...
Prophylaxis for haemophilia improves outcomes, but at a substantial cost. Cost-utility analysis balances improvements seen in health-related quality of life (HRQoL) against costs, with the purpose aiding healthcare decision-making. This uses measure HRQoL known as utility. The objective this study was to (utility) values states health that result from on-demand therapy or prophylaxis. different (including target joint bleeding, intensities prophylaxis, and indwelling intravenous catheters...
Establishment of mixed chimerism is an ideal approach to induce donor-specific tolerance while expanding its potential in various clinical settings. Despite the developments partial conditioning regimens, improvements are still needed reducing toxicity and bone marrow transplantation-related complications. Recently, cell-based therapies, including mesenchymal stem cells (MSCs), have been incorporated establishing noncytoreductive protocols; however, efficacy only shows reversed...
A reverse dipping pattern, characterized by higher night-time blood pressure (BP) than daytime BP, is associated with the increased risk for cerebrovascular disease, cardiovascular events and all-cause mortality. However, little has known about association between white matter change (WMC) particularly in normotensive adults. We aimed to examine whether WMC BP patterns as measured a 24-h ambulatory monitoring obstructive sleep apnoea (OSA) involved this relationship: total of 703 adults were...
[Purpose]This study aimed to examine the effects of task-oriented exercise therapy and cognitive on recovery hand function quality life in chronic stroke patients. [Subjects Methods] A total 16 patients with were selected divided into two groups. Group I (n = 8) received II therapy. This was conducted for eight weeks. Upper limb assessed using Fugl-Meyer assessment (FMA) manual test (MFT); activities daily living motor activity log (MAL); impact scale (SIS). The pre- post-intervention...
Inflammatory bowel disease (IBD) is chronic inflammation of the gastrointestinal tract caused by high levels pro-inflammatory cytokines and epithelial barrier dysfunction. Alnus japonica Steud. (Betulaceae) has been used in traditional Asian medicine. However, potential A. for treatment intestinal not investigated. This study investigated effects ethanol extract from bark (AJE) on colonic mucosa injury mice with dextran sodium sulfate (DSS)-induced colitis. Treatment AJE ameliorated...
Objective: Although a significant positive association of vitamin D deficiency with coronary heart disease has been demonstrated in cross-sectional as well prospective studies, only few studies have examined the subclinical atherosclerosis. We whether is associated atherosclerosis, measured by artery calcification (CAC) asymptomatic adults.Methods: In population-based study, 195 men aged 40 to 49 years without cardiovascular were randomly selected (98 Caucasian and 97 Japanese American men)....
Breast reconstruction is crucial for patients who have undergone mastectomy breast cancer. Our bioabsorbable implants comprising an outer poly-l-lactic acid mesh and inner component filled with collagen sponge promote retain adipogenesis in vivo without the addition of exogenous cells or growth factors. In this study, we evaluated over time histologically at gene expression level using implant a rodent model. The were inserted inguinal dorsal regions animals. At 1, 3, 6, 12 months...
Research points to impaired cognitive performance in sleep clinic patients with obstructive apnea (OSA). However, inconsistent findings from various epidemiologic studies make this relationship less generalizable. The current study investigated the association between OSA and functional outcome measures, such as cognition, daytime sleepiness, quality of life, a Korean general population sample.A total 1492 participants Genome Epidemiology Study (KoGES) were included analyses. presence...
T helper (Th) 17 cells are a subset of that express interleukin (IL)-17 and initiate the inflammatory response in autoimmune diseases. Regulatory (Tregs) subpopulation produce forkhead box P3 (FOXP3) inhibit immune response. Graft versus host disease (GVHD) is complication allogeneic tissue transplantation, Th17 their proinflammatory activity play central role pathogenesis GVHD. Gene associated with retinoid-interferon-induced mortality (GRIM) 19, originally identified as nuclear protein,...
Pseudomonas syringae pv. tomato (Pst) causes a bacterial speck disease in and Arabidopsis. In Chinese cabbage, which host-pathogen interactions are not well understood, Pst does cause but rather elicits hypersensitive response. induces localized cell death <TEX>$H_2O_2$</TEX> accumulation, typical response, infiltrated cabbage leaves. Pre-inoculation with was found to induce resistance Erwinia carotovora subsp. carotovora, pathogen that soft rot cabbage. An examination of the expression...