A5101953434- Advanced Radiotherapy Techniques
- Lung Cancer Treatments and Mutations
- Lung Cancer Diagnosis and Treatment
- Management of metastatic bone disease
- Radiation Therapy and Dosimetry
- Effects of Radiation Exposure
- Esophageal Cancer Research and Treatment
- Lung Cancer Research Studies
- Ultrasound and Hyperthermia Applications
- Head and Neck Cancer Studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Anesthesia and Pain Management
- Endometrial and Cervical Cancer Treatments
- Brain Metastases and Treatment
- Gastric Cancer Management and Outcomes
- Growth Hormone and Insulin-like Growth Factors
- Cardiac, Anesthesia and Surgical Outcomes
- Medical Imaging Techniques and Applications
- Radiomics and Machine Learning in Medical Imaging
- Colorectal and Anal Carcinomas
- Animal Nutrition and Physiology
- Cancer survivorship and care
- Acute Myeloid Leukemia Research
- Radiopharmaceutical Chemistry and Applications
- Ovarian cancer diagnosis and treatment
Saitama Medical University
2015-2024
Social Insurance Saitama Chuo Hospital
2015-2024
University of Oxford
2023
Shizuoka Cancer Center
2006-2021
Tokyo Yamate Medical Center
2021
The University of Tokyo
2015
University of Miyazaki
2014
Gunma University
1998-2013
Hidaka Hospital
2013
Gifu University
1969-2010
Changes in blood pressure, heart rate and the time necessary for recovery from motor block after spinal anesthesia were compared 65 children, aged 8 months to 15 years, 17 adult patients. All patients had similar levels of sensory (T5-T3) following tetracaine, 0.3 mg/kg, plus pheny
Activation of 5-fluorouracil into its nucleotides requires phosphorylation by three pathways involving orotate phosphoribosyl-transferase (OPRT), uridine phosphorylase (UP), or thymidine (TP). In this study, we investigated the association between gene expressions these enzymes and antitumour effect. Gene in primary colorectal tumours were analysed a real-time reverse transcriptional–polymerase chain reaction method 37 patients receiving oral treatment tegafur-uracil leucovorin for...
Intravenous fluorouracil and leucovorin is the standard adjuvant treatment for stage III colon cancer. However, oral chemotherapy attractive because it has low toxicity greater convenience. We investigated benefits of protein-bound polysaccharide K (PSK) with tegafur/uracil (UFT) as an in II colorectal Patients were assigned to groups that received either 3 g PSK plus 300 mg UFT, or UFT alone orally each day a 2-year period following intravenous mitomycin C. Of 207 registered patients, 205...
A strictly controlled thiobarbiturate–succinylcholine–oxygen sequence, with thiobarbiturate dosage 4-7 mg/kg, seems safe for elective cesarean section. Two hundred and forty-eight patients were divided into four groups, which received 4, 5⅓ 6⅓ or 8 mg/kg of thiobarbiturate, respectively. Blood samples barbiturate analysis drawn at birth from the maternal antecubital vein umbilical artery vein. Apgar scores good (7-0) in 75-90 per cent, fair (4-6) 6-19 infants first three but only 60 cent...
We report a new technique of brachytherapy consisting intracavitary combined with computed tomography (CT)-guided interstitial for locally advanced cervical cancer. A Fletcher-Suit applicator and trocar point needles were used performing high-dose rate under in-room CT guidance. First, tandem ovoids implanted into the patient's vagina uterus by conventional method. Based on clinical examination MRI/CT imaging, operating radiation oncologists decided positions insertion in tumor depth from...
The effects of nicardipine hydrochloride, a calcium channel Mocker, upon cerebrospinal fluid pressure (CSFP) were investigated in 47 patients without intracranial pathology who assigned to one three groups: group 1 (n = 17), received 0.01 mg/kg nicardipine, 2 0.02 mg/kg, and 3 13), 0.03 mg/kg. A spinal needle was inserted into the subarachnoid space permit continuous measurement CSFP. Nicardipine produced statistically significant increases CSFP: from mean 7.6 11.6 mm Hg 1, 7.2 12.2 2, 7.4...
The present study investigated the ability of carboplatin and paclitaxel to sensitize human non-small-cell lung cancer (NSCLC) cells carbon-ion beam irradiation. NSCLC H460 treated with or were irradiated X-rays beams, radiosensitivity was evaluated by clonogenic survival assay. Cell proliferation determined counting number viable using Trypan blue. Apoptosis senescence terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling (TUNEL) staining senescence-associated...
To determine whether concurrent chemotherapy with radiotherapy should be performed in elderly patients esophageal cancer.A total of 185 aged 80 years or older who were treated definitive alone combined chemoradiotherapy for cancer at seven institutions enrolled. In order to compare survival rates those alone, propensity score matching was homogenize the two populations.For whole patient cohort, 3-year overall (OS) rate 52.6% and median 42.5 months. After matching, OS group not significantly...
The purpose of this study is to evaluate the prediction and classification performances gamma passing rate (GPR) for different machine learning models select best model achieving learning-based patient-specific quality assurance (PSQA).The measurement verification 356 head-and-neck volumetric modulated arc therapy plans was performed using a diode array phantom (Delta4 Phantom), GPR values at 2%/2 mm with global normalization 3%/2 local were calculated. Machine models, including ridge...
Abstract The safety of weekly regional hyperthermia performed with 8 MHz radiofrequency ( RF ) capacitive heating equipment has been established in rectal cancer. We aimed to standardize treatment for scientific evaluation and assessing local tumor response Forty‐nine patients diagnosed adenocarcinoma were included the study. All received chemoradiation intensity‐modulated radiation therapy 5 days/week (dose, 50 Gy/25 times) concomitant five times capecitabine (1700 mg/m 2 per day) once a...
Between 1976 and 1992, 32 patients aged 75 older with stage I-II non-small cell lung cancer (NSCLQ were given definitive radiation therapy. These did not undergo surgery because of old age, poor cardiac/pulmonary condition, or refusal to give consent. The mean age was 79 years, 11 over 80 years old. histologic type squamous carcinoma in 25 adenocarcinoma 7. clinical T N T1N0 4 patients, T2N0 9, T2N1 19. total dose therapy each patient exceeded 60 Gy using 10-MV X-rays. treatment completed...
We examined the tissue distribution of growth hormone-releasing hormone (GHRH) receptor mRNA in rat brain because several lines evidence have suggested that GHRH plays a functional role brain. was detected hypothalamus as well pituitary, but not olfactory bulb, caudate putamen, cerebral cortex, hippocampus, cerebellum, or brainstem by RNase protection assay. To clarify precise localization hypothalamus, reverse transcription-polymerase chain reaction (RT-PCR) used. A PCR product predicted...
The effects of nitroglycerin on cerebrospinal fluid pressure (CSFP) and arterial blood were studied in 56 patients with normal CSFP. Thirty-two while awake, 24 anesthetized thiamylal, nitrous oxide oxygen. Nitroglycerin administered as an iv bolus produced marked increases CSFP decreases all studied. Maximal changes seen at 1–2 min following nitroglycerin, 4 μg/kg 8 μg/kg, 190 ± 8.3 (mean SE) 286 53.6 per cent control, respectively. transient return to control values occurred within 2–3...
This study aimed to analyze whether Ulinastatin, a urinary trypsin inhibitor (UTI), inhibits the TGF-β signaling pathway and lung fibrosis induced by thoracic irradiation in injury mouse model. The thoraces of 9-week-old female fibrosis-sensitive C57BL/6 mice were irradiated with single X-ray dose 12 Gy or 24 Gy. UTI was administrated intraperitoneally at 200,000 units/kg concurrently radiation (concurrent UTI) daily during post-irradiation period for 8–14 days (post-RT UTI). Mice sacrificed...
Hypoxia-inducible factor 1α (HIF-1α) is an intrinsic marker of tumor hypoxia. It has been considered that hypoxic conditions reduce radiosensitivity, but the role HIF-1α in patients treated with preoperative therapy for rectal cancer still unclear. The aim this study was to evaluate predictive value response hyperthermo-chemoradiotherapy (HCRT) and prognostic significance expression locally advanced cancer. Between 2003 2006, 50 histologically proven adenocarcinoma who underwent HCRT...