A5101750702- Advanced Radiotherapy Techniques
- Radiation Therapy and Dosimetry
- Endometrial and Cervical Cancer Treatments
- Prostate Cancer Diagnosis and Treatment
- Medical Imaging Techniques and Applications
- Lung Cancer Diagnosis and Treatment
- Prostate Cancer Treatment and Research
- Head and Neck Cancer Studies
- Lung Cancer Treatments and Mutations
- Management of metastatic bone disease
- Effects of Radiation Exposure
- Glioma Diagnosis and Treatment
- Brain Metastases and Treatment
- Ovarian cancer diagnosis and treatment
- Colorectal and Anal Carcinomas
- Lung Cancer Research Studies
- Radiation Dose and Imaging
- Esophageal Cancer Research and Treatment
- Advanced X-ray and CT Imaging
- Pancreatic and Hepatic Oncology Research
- Cervical Cancer and HPV Research
- Radiomics and Machine Learning in Medical Imaging
- Advances in Oncology and Radiotherapy
- Cancer, Hypoxia, and Metabolism
- Gastric Cancer Management and Outcomes
Osaka University
2016-2025
Osaka University Hospital
2012-2018
Toranomon Hospital
2017
Takarazuka City Hospital
2015-2016
University Medical Center Groningen
2015
University of Groningen
2015
University of the Ryukyus
2005-2015
Juntendo University Urayasu Hospital
2015
NTT WEST Osaka Hospital
2015
Okinawa University
2010-2011
N6-methyladenosine (m6A) is the most abundant epitranscriptome modification in mammalian mRNA. Recent years have seen substantial progress m6A epitranscriptomics, indicating its crucial roles initiation and progression of cancer through regulation RNA stabilities, mRNA splicing, microRNA processing translation. However, by what means dynamically regulated or written enzymatic components represented methyltransferase-like 3 (METTL3) how significant for each numerous genes remain unclear. We...
Enhancer of zeste homologue 2 (EZH2), a member the polycomb group protein family, plays crucial role in regulation embryonic development and has been associated with cell cycle. Recently, several studies have shown that EZH2 is highly expressed aggressive tumours, including human breast cancer, prostate lymphomas. We thus analysed expression using real-time reverse transcription–polymerase chain reaction, correlated its status various clinicopathological parameters 66 patients hepatocellular...
Thymic carcinomas are rare neoplasms, and information regarding the results of treatment possible prognostic factors in patients with these tumors is limited.The records 40 histologically confirmed thymic carcinoma who were treated between 1984 1998 reviewed. Twenty-seven surgical resection followed by radiotherapy or without chemotherapy, remaining 13 chemotherapy. The median follow-up time for surviving was 87 months (range, 44-193 months).The 5-year 10-year actuarial overall survival...
Optimal management of postoperative radiotherapy for patients with completely resected thymoma remains controversial. This study was conducted to assess the efficacy mediastinal irradiation in thymoma.The records 103 who received during period between 1979 and 1998 were reviewed. The distribution according Masaoka stage Stage I 17 patients, II 61 III 25 patients. Fifty-two treated involved field (IF) irradiation, 51 whole or without boost (WM irradiation). total radiation dose primary tumor...
The objective of this study was to retrospectively analyse the treatment results clinically localised angiosarcoma scalp and face.The records 48 patients who were treated between 1987 2009 reviewed. single modality or a combination surgery, radiotherapy, chemotherapy immunotherapy administered. median follow-up all 13.7 months (range 2.5-105.9 months).At time analysis, 45 (93.8%) had disease recurrences, lung most frequent site for recurrence (37 patients). In multivariate performance status...
Abstract Background The purpose of this study was to determine prospectively both human papillomavirus (HPV) load and physical status in different types head neck squamous cell carcinoma (HNSCC). Methods HPV DNA, E6/E7 mRNA expression, viral load, 184 patients with HNSCC were examined simultaneously by polymerase chain reaction (PCR)‐based methods. Results genome detected 54 samples (29.3%), particularly tonsillar carcinomas (69.6%). Compared nonoropharyngeal HNSCC, oropharyngeal harbored a...
Carbon ion radiotherapy has been utilized even for X-ray resistant tumors. However, control of distant metastasis remains a major challenge in carbon irradiation. We investigated whether irradiation combined with dual immune checkpoint blockade therapy (anti-PD-L1 and anti-CTLA-4 antibodies [P1C4]) provides anti-tumor efficacy both local sites. A mouse osteosarcoma cell line (LM8) was inoculated into hind legs C3H mice assigned to four groups: no treatment (NoTX), P1C4, 5.3 Gy one leg...
Positron emission tomography and computed (PET-CT) is widely used to assess the response radiotherapy. However, ability of PET-CT predict treatment failure in human papillomavirus (HPV)-related squamous cell carcinoma head neck (HNSCC) unsatisfactory. We quantified circulating tumor HPV type16 DNA (ctHPV16DNA) using optimized droplet digital PCR 35 patients with HPV16-related HNSCC, who received radiotherapy or without chemotherapy, prospectively correlated ctHPV16DNA metabolic failure....
Single-cell RNA sequencing (scRNAseq) has been used to assess the intra-tumor heterogeneity and microenvironment of pancreatic ductal adenocarcinoma (PDAC). However, previous knowledge is not fully universalized. Here, we built a single cell atlas PDAC from six datasets containing over 70 samples >130,000 cells, demonstrated its application reanalysis bulk transcriptomic cohorts inferring cell-cell communications. The decomposition transcriptomics using scRNAseq data showed cellular PDAC;...
Abstract BACKGROUND Brain metastases from esophageal carcinoma are extremely rare, and information regarding the natural history, results of treatment, possible prognostic factors in these patients is limited. METHODS The records 36 with brain who were treated between 1986 2000 reviewed. For metastases, 12 (33%) surgical resection followed by radiation therapy (S+RT), remaining 24 alone. RESULTS At initial diagnosis carcinoma, median primary tumor length was 8 cm (range, 2–19 cm), 26 32...
Abstract Purpose: Human kallikrein gene 6 (KLK6) is a member of the human family, and recent studies have found that many kallikreins altered expression patterns in various malignancies. The purpose current study was to quantify KLK6 malignant benign colorectal tissues statistically analyze whether levels correlate with clinicopathologic variables prognosis patients cancer. Experimental Designs: Paired tissue samples from cancerous corresponding noncancerous were obtained 63 cancer who...
This study aimed to evaluate the effectiveness and feasibility of reirradiation using high-dose-rate interstitial brachytherapy (HDR-ISBT) in patients with recurrent cervical cancer.The records 52 consecutive women central pelvic recurrence who were salvaged HDR-ISBT-based retrospectively reviewed. Data regarding primary disease, follow-up findings, recurrence, treatment outcome, toxicities collected. Multivariate analysis was performed Cox proportional hazards regression model identify...
To identify groups of patients who derive clinical benefit from postoperative adjuvant concurrent chemoradiotherapy (CCRT), we retrospectively investigated the survival outcomes surgically treated early-stage cervical cancer patients.We reviewed medical records 316 with FIGO stage IB1-IIB had been radiotherapy (RT) (n = 124, RT group) or CCRT 192, after radical hysterectomy between January 1996 and December 2009. Of these, 187 displayed high-risk prognostic factors (high-risk group), 129...
Abstract While bone is a frequent target of breast cancer–associated metastasis, little known about the effects tumor–bone interactions on efficacy tumor-suppressing agents. Here we examined effect two FDA-approved dopamine modulators, fluphenazine and trifluoperazine, mammary tumor cells, osteoclasts, osteoblasts, osteocytes. These agents suppressed proliferation migration cells chiefly by antagonizing receptor D2 reduced resorption downregulating nuclear factor activated T cytoplasmic 1...
The aim of this work is to generate synthetic computed tomography (sCT) images from multi-sequence magnetic resonance (MR) using an adversarial network and assess the feasibility sCT-based treatment planning for brain radiotherapy. Datasets 15 patients with glioblastoma were selected 580 pairs CT MR used. T1-weighted, T2-weighted fluid-attenuated inversion recovery sequences combined create a three-channel image as input data. A conditional generative (cGAN) was trained patches. quality...
Locoregional recurrence after carbon-ion radiotherapy (CIRT) for primary head and neck malignancies, such as malignant mucosal melanoma, adenoid cystic carcinoma, sarcoma, occurs occasionally. However, the treatment options are limited. We report on toxicity efficacy of re-irradiation using carbon ions recurrent malignancies CIRT.Data 48 patients with treated CIRT at our institution (2007-2016) were retrospectively analyzed. Twenty-one (43.8%) had 17 (35.4%) six (12.5%) bone soft tissue...
In this study, we report our experience in commissioning a commercial treatment planning system (TPS) for fast-raster scanning of carbon-ion beams. This TPS uses an analytical dose calculation algorithm, pencil-beam model with triple Gaussian form the lateral-dose distribution, and beam splitting algorithm to consider lateral heterogeneity medium. We adopted mixed as relative biological effectiveness (RBE) calculating RBE values scanned beam. To validate modeled physical dose, compared...
Abstract RNA modifications, including the renowned m6A, have recently garnered significant attention. This chemical alteration, present in mRNA, exerts a profound influence on protein expression levels by affecting splicing, nuclear export, stability, translation, and other critical processes. Although role of methylation pathogenesis progression IBD colorectal cancer has been reported, many aspects remain unresolved. In this comprehensive review, we recent studies cancer, with particular...
Abstract BACKGROUND The relative roles of surgical resection, radiotherapy, and chemotherapy in the management patients with intracranial nongerminomatous malignant germ cell tumors have been controversial. authors retrospectively investigated results different treatment regimens these tumors. METHODS records 41 who were treated between 1981 2001 reviewed. They grouped into a good prognosis ( n = 3), an intermediate 24), poor 14) based on histology their Fifteen (37%) underwent resection...