A5025478768- Endometrial and Cervical Cancer Treatments
- Advanced Radiotherapy Techniques
- Cervical Cancer and HPV Research
- Radiation Therapy and Dosimetry
- Colorectal and Anal Carcinomas
- Management of metastatic bone disease
- Ovarian cancer diagnosis and treatment
- Cancer Immunotherapy and Biomarkers
- Prostate Cancer Diagnosis and Treatment
- Immunotherapy and Immune Responses
- Prostate Cancer Treatment and Research
- Radiomics and Machine Learning in Medical Imaging
- Head and Neck Cancer Studies
- Glioma Diagnosis and Treatment
- Ultrasound and Hyperthermia Applications
- Lung Cancer Diagnosis and Treatment
- Pelvic and Acetabular Injuries
- Uterine Myomas and Treatments
- Effects of Radiation Exposure
- Hepatocellular Carcinoma Treatment and Prognosis
- Immune Response and Inflammation
- Cancer Research and Treatments
- Advanced Glycation End Products research
- Advances in Oncology and Radiotherapy
- Medical Imaging Techniques and Applications
National Institutes for Quantum Science and Technology
2016-2025
Juntendo University
2024-2025
Taisei (Japan)
2024-2025
Gunma University
2011-2024
Tokyo Health Care University
2022-2024
Fukushima Medical University
2019
Institute of Genetics and Cancer
2019
University of Edinburgh
2019
Edinburgh Cancer Research
2019
Heriot-Watt University
2019
Purpose There is growing evidence that tumor-specific immune responses play an important role in anti-cancer therapy, including radiotherapy. Using mouse tumor models we demonstrate irradiation-induced anti-tumor immunity essential for the therapeutic efficacy of irradiation and can be augmented by modulation cytotoxic T lymphocyte (CTL) activity. Methods Materials C57BL/6 mice, syngeneic EL4 lymphoma cells, Lewis lung carcinoma (LL/C) cells were used. Cells injected into right femurs mice....
Abstract Herein, we investigate the long-term clinical outcomes for cervical cancer patients treated with in-room computed tomography–based brachytherapy. Eighty Stage IB1–IVA cancer, who had undergone treatment combined 3D high-dose rate brachytherapy and conformal radiotherapy between October 2008 May 2011, were retrospectively analyzed. External beam (50 Gy) central shielding after 20–40 Gy was performed each patient. Cisplatin-based chemotherapy administered concurrently to...
Abstract Carbon ion radiotherapy shows great potential as a cure for X-ray-resistant tumors. Basic research suggests that the strong cell-killing effect induced by carbon ions is based on their ability to cause complex DNA double-strand breaks (DSBs). However, evidence supporting formation of DSBs in actual patients lacking. Here, we used advanced high-resolution microscopy with deconvolution show are formed human tumor clinically treated radiotherapy, but not X-ray radiotherapy....
X-ray radiotherapy activates tumor antigen-specific T-cell responses, and increases in the serum levels of high mobility group box 1 (HMGB1) induced by irradiation play a pivotal role activating anti-tumor immunity. Here, we examined whether carbon-ion beams, as well X-rays, can induce HMGB1 release from human cancer cell lines. The study five lines: TE2, KYSE70, A549, NCI-H460 WiDr. proportion cells surviving X- or beam was assessed clonogenic assay. D 10 , dose at which 10% survive,...
PurposeWe report herein the 3-year results of a phase I/II prospective study 4-fraction course carbon-ion radiotherapy (CIRT) in patients with localized prostate cancer.Materials and MethodsThe present was single-institution, including low- or intermediate-risk cancer, as defined by National Comprehensive Cancer Network criteria. Eligible were randomly assigned (1:1) to one- two-week schedule. Dose-limiting toxicities (DLTs) any genitourinary (GU) gastrointestinal (GI) toxicity grade 3...
Anti-tumor immunity modulates the local effects of radiation therapy. High mobility group box 1 (HMGB1) plays a pivotal role in activating antigen-specific T-cell responses. Here, we examined relationship between linear energy transfer (LET) and HMGB1 release. We assessed proportions KYSE-70, HeLa SiHa cells surviving after carbon-ion (C-ion) beam irradiation with different LET values, using clonogenic assay. The D10, dose at which 10% survived, was calculated linear–quadratic model. levels...
The local control rate of chondrosarcomas treated with carbon-ion radiotherapy (CIRT) worsens as tumour size increases, possibly because the intra-tumoural linear energy transfer (LET) distribution. This study aimed to evaluate relationship between recurrence and LET distribution in CIRT.Thirty patients CIRT for grade 2 chondrosarcoma were included. Dose-averaged (LETd) was calculated by treatment planning system, LETd volume (PTV) evaluated.The mean value PTV similar cases without...
Metabotropic glutamate receptor 1 (mGluR1), a key mediator of glutamatergic signaling, is frequently overexpressed in tumor cells and an attractive drug target for most cancers. Here, we present targeted radiopharmaceutical therapy strategy that antagonistically recognizes mGluR1 eradicates mGluR1+ human tumors by harnessing small-molecule alpha (α)-emitting radiopharmaceutical, 211At-AITM. A single dose 211At-AITM (2.96 MBq) cancers exhibits long-lasting vivo antitumor efficacy across seven...
Abstract We conducted a phase 1/2 study to evaluate the efficacy and safety of carbon ion radiotherapy (C‐ion RT ) with concurrent chemotherapy for locally advanced uterine cervical adenocarcinoma. Thirty‐three patients were enrolled between April 2010 March 2014. Treatment consisted C‐ion weekly cisplatin at dose 40 mg/m 2 . In 1 component, total was escalated from 68.0 Gy (relative biological effectiveness [ RBE ]) 74.4 ( determine maximum tolerated evaluated using determined in component....
Objective: Programmed cell death-ligand 1 (PD-L1) is expressed in tumor cells and has been shown to predict clinical outcomes of several types malignancies.The aim this study was investigate the effects carbon-ion (C-ion) beam irradiation on PD-L1 expression human uterine cervical adeno/adenosquamous carcinoma (UCAA) samples identify prognostic factors for after C-ion radiotherapy (CIRT).Methods: The UCAA squamous were examined by flow cytometry.We biopsy specimens from 33 patients before...
The current study aimed to evaluate the outcomes of patients with adenocarcinoma (AC) uterine cervix after definitive radiotherapy (RT) and prognostic factors, including immunity-related molecules. A total 71 AC from multiple Japanese institutions were retrospectively analysed. Histological subtypes diagnosed according 2014 World Health Organization classification. All underwent RT comprising external beam intracavitary brachytherapy or without concurrent chemotherapy. Immunohistochemical...
Objective Enhancing immunologic responses, including human leukocyte antigen (HLA) class I expression on tumor cells and recognition elimination of by tumor-specific cytotoxic T lymphocyte (CTL), is considered a novel concept radiotherapy. The present study examined patients who underwent preoperative hyperthermo-chemoradiotherapy (HCRT) for locally advanced rectal cancer to assess the correlation between HLA clinical outcome. Materials Methods Seventy-eight with adenocarcinoma received HCRT...
Radiotherapy induces an immune response in the cancer microenvironment that may influence clinical outcome. The present study aimed to analyse alteration of CD8<sup>+</sup> T‑cell infiltration and programmed death‑ligand 1 (PD‑L1) expression following radiotherapy samples from patients with uterine cervical squamous cell carcinoma. Additionally, current sought association between these responses outcomes. A total 75 who received either definitive chemoradiotherapy or were retrospectively...
Background and purposeSeveral studies have focused on increasing the linear energy transfer (LET) within tumours to achieve higher biological effects in carbon-ion radiotherapy (C-ion RT). However, it remains unclear whether LET affects late complications. We assessed physical dose distribution can be specific factors for rectal complications C-ion RT.Materials methodsOverall, 134 patients with uterine carcinomas were registered retrospectively analysed. Of patients, 132 who followed up >6...
Abstract This study assessed the significance of hands-on-training (HoT) and questionnaire-based surveys on 3D image-guided brachytherapy (3D-IGBT) a combination intracavitary interstitial brachytherapy, so-called ‘hybrid’ BT (HBT), in uterine cervical cancer. In October 2023, 29 radiation oncologists, nurses, radiologic technologists medical physicists from 10 Japanese facilities participated an HoT 3D-IGBT HBT. Questionnaires were distributed to each participant before after HoT, feedback...
Abstract The safety of weekly regional hyperthermia performed with 8 MHz radiofrequency ( RF ) capacitive heating equipment has been established in rectal cancer. We aimed to standardize treatment for scientific evaluation and assessing local tumor response Forty‐nine patients diagnosed adenocarcinoma were included the study. All received chemoradiation intensity‐modulated radiation therapy 5 days/week (dose, 50 Gy/25 times) concomitant five times capecitabine (1700 mg/m 2 per day) once a...
Human papillomavirus (HPV) infection is well known as a major etiological risk factor associated with carcinogenesis in uterine cervical cancer. However, few reports have investigated the association between HPV genotype and outcome patients cancer following radiotherapy (RT). The aim of present study was to investigate clinical RT Japanese Between November 2001 August 2006, 157 women were treated or concurrent chemoradiotherapy curative intent. Pretreatment, formalin‑fixed,...
The majority of uterine cervical cancer is known to be related human papillomavirus (HPV), and HPV-related tumors are radio-sensitive. In the management oropharyngeal cancer, de-intensification treatment has been attempted; however, no such attempt performed in cancer. aim this study was identify a group patients who can safely treated by de-escalated intensity.From Asian international multi-institutional retrospective involving 13 Japanese, one Thailand, Korean institutions based on 469...