A5016754371- Prostate Cancer Treatment and Research
- Prostate Cancer Diagnosis and Treatment
- Asthma and respiratory diseases
- Blood Coagulation and Thrombosis Mechanisms
- Head and Neck Cancer Studies
- Advanced Radiotherapy Techniques
- Salivary Gland Tumors Diagnosis and Treatment
- Radiation Therapy and Dosimetry
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Amino Acid Enzymes and Metabolism
- Urologic and reproductive health conditions
- Lung Cancer Diagnosis and Treatment
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Head and Neck Surgical Oncology
- Inhalation and Respiratory Drug Delivery
- Advanced Glycation End Products research
- Medical Imaging and Pathology Studies
- Mitochondrial Function and Pathology
- Nonmelanoma Skin Cancer Studies
- Neurofibromatosis and Schwannoma Cases
- Respiratory Support and Mechanisms
- Colorectal and Anal Carcinomas
- Nanoplatforms for cancer theranostics
- RNA modifications and cancer
- Vascular Tumors and Angiosarcomas
Gunma University
2015-2025
Gunma University Hospital
2025
Hidaka Hospital
2018-2022
National Institutes for Quantum Science and Technology
2018
Mie University
2011-2016
Saitama Cancer Center
2016
Center Point
2012
Tokushima University
2000
Central Research Laboratories (United Kingdom)
1983
Anti-tumor immunity modulates the local effects of radiation therapy. High mobility group box 1 (HMGB1) plays a pivotal role in activating antigen-specific T-cell responses. Here, we examined relationship between linear energy transfer (LET) and HMGB1 release. We assessed proportions KYSE-70, HeLa SiHa cells surviving after carbon-ion (C-ion) beam irradiation with different LET values, using clonogenic assay. The D10, dose at which 10% survived, was calculated linear–quadratic model. levels...
378 Background: The potential of carbon ion radiation therapy (CIRT) as a curative treatment for localized prostate cancer (PCa) has garnered attention due to its characteristic dose distribution. There is no data on long-term urinary function or changes in volume patients after CIRT. We prospectively collected and analyzed over five years investigate the outcomes related PCa treated with Methods: This study included classified T1-T3N0M0 according TNM staging system. A total 309 who...
This study aimed to assess the long-term outcomes of radiotherapy in patients with localized gastric mucosa-associated lymphoid tissue (MALT) lymphoma. Twenty-seven Stage I MALT lymphoma were treated from 1999 2010. The median age was 65 years (range: 31-84). Fifteen Helicobacter pylori-negative. Thirteen definitive alone. other 14 who had refractory or residual disease following a prior treatment received salvage radiotherapy. dose 30 Gy 20 fractions 30-39.5 Gy). follow-up period 121 months...
We investigated the clinical outcomes of helical tomotherapy in 23 patients aged ≥80 years with localized and locally advanced prostate cancer compared results data from 171 under 80 years. All received our hospital between September 2009 October 2012. The median follow-up periods were 35 months group 34 younger group. prescribed dose was 78 Gy 39 fractions (range, 72–78 Gy). 3-year overall survival biochemical relapse-free rates 92% 96% 99.4% 97.3% group, respectively. There no significant...
Recently, the clinical outcome of prostate cancer treated by hypofractionated radiation therapy has been reported. However, there are few reports from Japan. In Hidaka Hospital, intensity-modulated radiotherapy (HIMRT) for was initiated in 2007. The purpose this study is to analyze long-term outcome.Ninety-two patients with localized HIMRT at Hospital between 2007 and 2009 were retrospectively analyzed. delivered using TomoTherapy. prescription dose 66 Gy 95% PTV 22 fractions performed 3...
The potential of carbon ion radiation therapy (CIRT) as a curative treatment for localized prostate cancer (PCa) has garnered attention due to its characteristic dose distribution. We prospectively collected and analyzed over five years investigate the outcomes PCa treated with CIRT at our institution. study included patients histologically confirmed adenocarcinoma. was administered total 57.6 Gy (RBE) in 16 fractions four weeks. Uroflowmetry (UFM) residual urine measurements were performed...
Abstract Introduction Benign metastasizing leiomyoma in the lung is a very rare disease characterized by growth of uterine tissue. In most cases there previous history hysterectomy for leiomyoma. Case presentation A 50-year-old Asian woman underwent total abdominal at age 37 years old. She was referred to our hospital because sudden anterior chest pain. computed tomography scan revealed ground-glass opacity her left S10 segment and solitary small nodule bronchial segment, S4. We performed...
To determine the most reliable predictor for pathologic complete response (pCR) in patients who underwent preoperative chemoradiotherapy and regional hyperthermia (HCRT) rectal cancer.Thirty-six were enrolled. The local control status of was assessed using 18F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT), magnetic resonance imaging (MRI), colonoscopy before after HCRT. relationships between various parameters these clinical examinations pCR analyzed.Ten...
This study aimed to evaluate clinical outcomes and the toxicity of intensity-modulated radiation therapy with simultaneous integrated boost (SIB-IMRT) combined androgen-deprivation for clinically node-positive (cN1) prostate cancer. We retrospectively analyzed 97 patients cN1 cancer who received SIB-IMRT between June 2008 October 2017 at our hospital. The prescribed dosages delivered seminal vesicle, elective node area, residual lymph nodes were 69, 54, 60 Gy in 30 fractions, respectively....
The promising results of the PACIFIC study led to approval consolidation durvalumab for coverage by National Health Insurance (NHI) in 2018 patients with locally-advanced unresectable non-small cell lung carcinoma (NSCLC) treated definitive concurrent chemoradiotherapy (CCRT). However, effect NHI on patterns care this population remains unclear. Here, we conducted a questionnaire-based survey determine stage II-III NSCLC radiotherapy 2017 (pre-durvalumab era) or 2019 (post-durvalumab era)....
Abstract Background The quality of life patients is an important consideration when selecting treatments for localized prostate cancer (PCa). We retrospectively compared sexual function after robot-assisted radical prostatectomy (RARP) and carbon-ion radiotherapy (CIRT) using propensity score matching. Methods In total, 127 Japanese PCa treated with RARP 190 CIRT monotherapy were evaluated. evaluated the Expanded Prostate Cancer Index Composite (EPIC) before treatment 12 24 months treatment....
In 2021, Japan's medical expenses will exceed 45 trillion yen, and the shortage of doctors, especially in remote mountainous areas, is becoming serious, making it difficult to maintain system. We have conducted a study 800 health consultation text data. developed an on-premise counseling LLM system by constructing dialogue flow based on Turing test this using 200 data verified its effectiveness with three professionals. The was comparison experiment between conventional infrastructure...
Journal Article Irreversible Extrusion of the First Loop Facing Matrix Bovine Heart Mitochondrial ADP/ATP Carrier by Labeling Cys56 Residue with SH-Reagent Methyl Methanethiosulfonate Get access Mitsuru Hashimoto, Hashimoto *Faculty Pharmaceutical Sciences, University ofTokushimaShomachi-1, Tokushima 770-8505 Search for other works this author on: Oxford Academic PubMed Google Scholar Eyi Majima, Majima 770-8505†APRO Life Science InstituteKurosaki, Naruto 772-0001 Takashi Hatanaka, Hatanaka...
<b>Background:</b> Bronchial asthma is a chronic inflammatory disease characterized by airway infiltration of cells (eg, eosinophils, lymphocytes), and obstructive changes hyperresponsiveness the airways. Chronic inflammation leads to remodeling. Matrix metalloproteinase-2 (MMP2) critical regulator extracellular matrix. The role MMP2 in bronchial unclear. <b>Aims Objects:</b> objective present study was assess asthma. <b>Methods:</b> We developed novel MMP-2 transgenic (TG) mouse that...
We conducted a nationwide survey of tomotherapy for malignant pleural mesothelioma (MPM) in Japan. Fifty-six facilities were surveyed and data on 31 patients treated curatively between 2008 2017 collected from 14 facilities. Twenty received hemithorax irradiation after extrapleural pneumonectomy (EPP) (first group). Five without EPP (second group), while six salvage radiotherapy local recurrence (salvage Among the seven not undergoing EPP, five (four second group one group) with lung sparing...