A5102802674- Head and Neck Cancer Studies
- Advanced Radiotherapy Techniques
- Radiation Therapy and Dosimetry
- Lung Cancer Diagnosis and Treatment
- Salivary Gland Tumors Diagnosis and Treatment
- Head and Neck Surgical Oncology
- Lung Cancer Research Studies
- Ultrasound and Hyperthermia Applications
- Cancer, Hypoxia, and Metabolism
- Lung Cancer Treatments and Mutations
- Oral health in cancer treatment
- Endometrial and Cervical Cancer Treatments
- Sarcoma Diagnosis and Treatment
- Effects of Radiation Exposure
- Cancer Diagnosis and Treatment
- Brain Metastases and Treatment
- Management of metastatic bone disease
- Ear and Head Tumors
- Cancer-related Molecular Pathways
- Radiomics and Machine Learning in Medical Imaging
- Medical Imaging Techniques and Applications
- Cell death mechanisms and regulation
- Lymphoma Diagnosis and Treatment
- Glioma Diagnosis and Treatment
- Ovarian cancer diagnosis and treatment
University of Toyama
2018-2025
Gunma University Hospital
2011-2023
Gunma University
2009-2021
Jichi Medical University
2021
Social Insurance Saitama Chuo Hospital
2013
Saitama Medical University
2013
Hidaka Hospital
2013
Saitama Cancer Center
2009-2011
Keio University
1998-1999
Institute of Metal Research
1990-1991
PurposeTo evaluate the efficacy and safety of carbon-ion radiation therapy (RT) for mucosal melanoma head neck (MMHN) in Japan Carbon-Ion Radiation Oncology Study Group study.Methods MaterialsPatients with MMHN N0-1M0 status who were treated RT at 4 institutions between November 2003 December 2014 analyzed retrospectively. Two hundred sixty patients (male, 111; female, 149; median age, 68 years) histologically proven enrolled.ResultsPrimary sites included nasal cavity 178 patients, paranasal...
Abstract Gold nanoparticles (Au-NPs) have attracted attention as a promising sensitizer owing to their high atomic number (Z), and because they are considered fully multifunctional, preferred over other metal nanoparticles. Cold atmospheric plasma (CAP) has also recently gained attention, especially for cancer treatment, by inducing apoptosis through the formation of reactive oxygen species (ROS). In this study, activity different sized Au-NPs with helium-based CAP (He-CAP) was analyzed,...
Abstract Herein, we investigate the long-term clinical outcomes for cervical cancer patients treated with in-room computed tomography–based brachytherapy. Eighty Stage IB1–IVA cancer, who had undergone treatment combined 3D high-dose rate brachytherapy and conformal radiotherapy between October 2008 May 2011, were retrospectively analyzed. External beam (50 Gy) central shielding after 20–40 Gy was performed each patient. Cisplatin-based chemotherapy administered concurrently to...
The efficacy and toxicity of three-fraction CyberKnife radiotherapy were evaluated in patients with brain metastases critical areas. One hundred fifty-nine 145 including tumors >10 cm(3) treated a median marginal dose 27 Gy at prescribed isodose 60%. Changes the neurological manifestations, local tumor control adverse effects investigated after treatment. surrounding volumes circumscribed 23.1 (single equivalence 14 Gy: V14) measured to evaluate risk effects. Neurological such as motor...
The purpose of this study was to compare carbon ion radiotherapy (C-ion RT) and stereotactic (SBRT) with photon beams for the treatment hepatocellular carcinoma (HCC), specifically regard dose volume parameters target coverage normal tissue sparing. Data 10 patients who were treated using C-ion RT a total 60 Gy(RBE) in four fractions used. virtual plan SBRT simulated on planning computed tomography images RT. Dose such as minimum covering 90 % (PTV D90), homogeneity index (HI), conformity...
To evaluate the safety and efficacy of carbon-ion radiation therapy (C-ion RT) for locally advanced sinonasal malignant tumors in a multicenter retrospective study (J-CROS 1402 HN).Clinical data were collected patients who had stage N0-1M0 received C-ion RT at 4 institutions Japan between November 2003 December 2014. Of 458 patients, 393 naïve 65 recurrent tumors. The located nasal cavity (n = 263), maxillary sinus 109), ethmoid 71), other locations 15). histologic types mucosal melanoma...
We report a new technique of brachytherapy consisting intracavitary combined with computed tomography (CT)-guided interstitial for locally advanced cervical cancer. A Fletcher-Suit applicator and trocar point needles were used performing high-dose rate under in-room CT guidance. First, tandem ovoids implanted into the patient's vagina uterus by conventional method. Based on clinical examination MRI/CT imaging, operating radiation oncologists decided positions insertion in tumor depth from...
To evaluate the efficacy and safety of carbon‐ion radiotherapy for non‐squamous cell carcinoma head neck, 35 patients were enrolled in this prospective study. The primary end‐point was 3‐year local control rate, secondary end‐points included overall survival rate adverse events. Acute late events evaluated according to Common Terminology Criteria Adverse Events, version 4.0. median follow‐up time all 39 months. Thirty‐two three received 64.0 Gy (relative biological effectiveness) 57.6 16...
Purpose To evaluate the dose-response relationship for development of acute radiation mucositis (ARM) using an oral mucosal dose surface model (OMDS-model) in carbon ion radiotherapy (C-ion RT) head and neck tumors. Methods Thirty-nine patients receiving C-ion RT cancer were evaluated ARM (once per week 6 weeks) according to Common Terminology Criteria Adverse Events (CTCAE), version 4.0, Radiation Therapy Oncology Group (RTOG) scoring systems. The irradiation schedule typically used was 64...
A retrospective multicenter study was carried out to assess the clinical outcomes of carbon‐ion radiotherapy for head and neck malignancies (Japan Carbon‐Ion Radiation Oncology Study Group [J‐ CROS ] study: 1402 HN ). We evaluated safety efficacy in patients with major salivary gland carcinoma. Sixty‐nine treated at four Japanese institutions were analyzed. Thirty‐three (48%) had adenoid cystic carcinomas, 10 (14%) mucoepidermoid 26 (38%) other disease types. Three (4%) T1 disease, 8 (12%)...
This study aimed to evaluate the clinical outcomes of patients with mucoepidermoid carcinomas in head and neck treated carbon-ion radiotherapy. Data from 26 who underwent radiotherapy four facilities were analyzed this multi-institutional retrospective study: Japan Carbon-ion Radiation Oncology Study Group. The median follow-up time was 34 months. One patient experienced local recurrence, 3-year control rate 95%. developed lymph node recurrence five distant metastases. progression-free...
Lung cancer is a leading cause of cancer-related deaths worldwide. Radiotherapy an essential treatment modality for inoperable non-small cell lung (NSCLC). Stereotactic body radiotherapy (SBRT) the standard early-stage NSCLC because its favorable local control (LC) compared to conventional radiotherapy. Carbon ion (CIRT) kind external beam characterized by steeper dose distribution and higher biological effectiveness. Several prospective studies have shown outcomes. However, there no direct...
A single-institutional prospective study of optimal hypofractionated conformal radiotherapy for large brain metastases with high risk factors was performed based on the prediction radiation-related complications.Eighty-eight patients ≥10 cm(3) in critical areas treated from January 2010 to February 2014 using CyberKnife were evaluated. The dose and number fractions determined surrounding volume circumscribed a single equivalent (SDE) 14 Gy (V14) be less than 7 individual lesions. Univariate...
Abstract The present study compared the dose–volume histograms of patients with Stage IIIA non–small cell lung cancer (NSCLC) treated carbon ion radiotherapy those X-ray radiotherapy. Patients NSCLC ( n = 10 for each approach) were enrolled. Both plans calculated same targets and organs at risk on CT. treatment plan prophylactic lymph node primary tumor (PTV1) delivered 40 Gy (relative biological effectiveness; RBE) total doses clinically positive nodes (PTV2) 60 (RBE) homogeneity indexes...
This study aimed to assess the long-term outcomes of radiotherapy in patients with localized gastric mucosa-associated lymphoid tissue (MALT) lymphoma. Twenty-seven Stage I MALT lymphoma were treated from 1999 2010. The median age was 65 years (range: 31-84). Fifteen Helicobacter pylori-negative. Thirteen definitive alone. other 14 who had refractory or residual disease following a prior treatment received salvage radiotherapy. dose 30 Gy 20 fractions 30-39.5 Gy). follow-up period 121 months...
Abstract This study aimed to evaluate the efficacy of carbon‐ion radiotherapy in combination with chemotherapy using dacarbazine, nimustine, and vincristine (DAV therapy) mucosal melanoma. Twenty‐one patients clinically localized melanoma head neck were enrolled. The primary endpoint was 3‐year overall survival (OS). Secondary endpoints included local control, progression‐free (PFS), adverse event occurrence. Carbon‐ion a dose 57.6‐64.0 Gy (relative biological effectiveness) 16 fractions...
This phase II study's aim was to confirm the efficacy and safety of hypofractionated carbon-ion radiotherapy in patients with stage I peripheral nonsmall cell lung cancer (NSCLC). The study encompassed 37 histologically proven NSCLC period June 2010-March 2015. All underwent planned full dose radiotherapy, administered relative biological effectiveness 52.8 Gy 60 (divided into four fractions over 1 week) for T1 T2a tumors, respectively. 2-year local control rate set as primary endpoint,...