A5043219078- Radiation Therapy and Dosimetry
- Advanced Radiotherapy Techniques
- Lung Cancer Diagnosis and Treatment
- Prostate Cancer Treatment and Research
- Prostate Cancer Diagnosis and Treatment
- Head and Neck Cancer Studies
- Medical Imaging Techniques and Applications
- Lung Cancer Treatments and Mutations
- Radiation Dose and Imaging
- Medical Imaging and Pathology Studies
- Radiation Detection and Scintillator Technologies
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Lung Cancer Research Studies
- Oral health in cancer treatment
- Cancer Diagnosis and Treatment
- Advances in Oncology and Radiotherapy
- Bladder and Urothelial Cancer Treatments
- Endometrial and Cervical Cancer Treatments
- Ovarian cancer diagnosis and treatment
- Salivary Gland Tumors Diagnosis and Treatment
- DNA Repair Mechanisms
- Head and Neck Surgical Oncology
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer Immunotherapy and Biomarkers
- Ear and Head Tumors
Gunma University Hospital
2016-2025
Gunma University
2016-2025
Beppu Medical Center
2025
National Hospital Organization
2025
University of Toyama
2020
Tokyo Metropolitan Komagome Hospital
2009-2010
Hokkaido University
2006
Jichi Medical University
1993
Carbon ion Radiotherapy for prostate cancer is widely used, however reports are limited from single institute or short follow up. We performed a prospective observational study (GUNMA0702) to evaluate the feasibility and efficacy of carbon radiotherapy localized locally advanced cancer.Between June 2010 August 2013, 304 patients with were treated, median follow-up duration 60 months. All received 57.6 Gy (RBE) in 16 fractions over 4 weeks. Hormonal therapy was given according risk group....
Radiotherapy is a standard treatment for inoperable stage I non-small cell lung cancer (NSCLC), and carbon-ion radiation therapy (CIRT) may be used such treatment. Although CIRT NSCLC has demonstrated favorable outcomes in previous reports, the reports covered only single-institution studies. We conducted prospective nationwide registry study including all institutions Japan.Ninety-five patients with were treated by between May 2016 June 2018. The dose fractionations selected from several...
Abstract Anti-cancer treatments for lung cancer patients with interstitial disease (ILD) are challenging. The treatment options ILD often limited because of concerns that can cause acute exacerbation (AE) ILD. This study aimed to analyze the outcomes carbon-ion radiotherapy (CIRT) stage I non-small cell (NSCLC) ILD, using a multi-institutional registry. Patients who received CIRT NSCLC in institutions Japan were enrolled. indication was determined by an institutional multidisciplinary tumor...
Abstract The present study compared the dose–volume histograms of patients with Stage IIIA non–small cell lung cancer (NSCLC) treated carbon ion radiotherapy those X-ray radiotherapy. Patients NSCLC ( n = 10 for each approach) were enrolled. Both plans calculated same targets and organs at risk on CT. treatment plan prophylactic lymph node primary tumor (PTV1) delivered 40 Gy (relative biological effectiveness; RBE) total doses clinically positive nodes (PTV2) 60 (RBE) homogeneity indexes...
Lung cancer is a leading cause of cancer-related deaths worldwide. Radiotherapy an essential treatment modality for inoperable non-small cell lung (NSCLC). Stereotactic body radiotherapy (SBRT) the standard early-stage NSCLC because its favorable local control (LC) compared to conventional radiotherapy. Carbon ion (CIRT) kind external beam characterized by steeper dose distribution and higher biological effectiveness. Several prospective studies have shown outcomes. However, there no direct...
Antimicrobial resistance is a global health concern, and methicillin-resistant Staphylococcus aureus (MRSA) one of the highest-priority organisms exhibiting this phenotype. Here, we performed national surveillance integrating patient clinical data S. isolated from bloodstream infections. We genome sequencing, standardized antimicrobial susceptibility testing, collected metadata 580 isolates during 2019–2020. focused on three predominant clonal complexes (CC1, CC5, CC8) assesses their...
The present study investigated the ability of carboplatin and paclitaxel to sensitize human non-small-cell lung cancer (NSCLC) cells carbon-ion beam irradiation. NSCLC H460 treated with or were irradiated X-rays beams, radiosensitivity was evaluated by clonogenic survival assay. Cell proliferation determined counting number viable using Trypan blue. Apoptosis senescence terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling (TUNEL) staining senescence-associated...
Abstract This study aimed to evaluate the efficacy of carbon‐ion radiotherapy in combination with chemotherapy using dacarbazine, nimustine, and vincristine (DAV therapy) mucosal melanoma. Twenty‐one patients clinically localized melanoma head neck were enrolled. The primary endpoint was 3‐year overall survival (OS). Secondary endpoints included local control, progression‐free (PFS), adverse event occurrence. Carbon‐ion a dose 57.6‐64.0 Gy (relative biological effectiveness) 16 fractions...
Introduction: The standard therapy for stage I non-small cell lung cancer (NSCLC) is surgery, but some operable patients refuse this option and instead undergo radiotherapy.Carbon-ion radiotherapy (CIRT) a type of radiotherapy.The Japanese prospective nationwide registry study on CIRT began in 2016.Here, we analyzed real-world clinical outcomes with NSCLC.Methods: All NSCLC treated Japan between 2016 2018 were enrolled.The dose fractionations selected from several options approved by the...
Background/Aim: The aim of this study was to assess the feasibility and safety hypofractionated carbon-ion radiotherapy (C-ion RT) in patients with stage III non-small cell lung cancer (NSCLC). Patients Methods: untreated, histologically proven, unresectable NSCLC not candidates for chemotherapy were included study. C-ion RT planned administered 4 Gy (relative biological effectiveness (RBE)) daily fractions a total dose 64 (RBE) without combined chemotherapy. Dose-limiting toxicity (DLT)...
Cardiac metastasis of uterine cervical cancer with antemortem diagnosis is extremely rare. Therefore, its landscape epidemiology has not been well elucidated to date. In the present study, a case solitary cardiac diagnosed reported, and review currently available literature (which includes 18 cases cancer) conducted. January 2013, 78-year-old woman squamous cell carcinoma (SCC) cervix (International Federation Gynecology Obstetrics stage IIIb) underwent definitive radiotherapy at Gunma...
Abstract Background Carbon‐ion radiotherapy (C‐ion RT) is effective for head and neck mucosal melanoma (HN‐MM), including radioresistant melanoma. Melanoma also responds effectively to immune checkpoint inhibitors (ICIs). Data on the efficacy safety of ICIs HN‐MM are insufficient. Aims To analyze ICI salvage therapy in patients with recurrence after C‐ion RT. Methods Results This retrospective study analyzed medical records 52 treated RT between 2012 2020. A dose 57.6 or 64.0 Gy (relative...
// Endang Nuryadi 1, 2, * , Yasushi Sasaki 3, Yoshihiko Hagiwara Tiara Bunga Mayang Permata 2 Hiro Sato 1 Shuichiro Komatsu Yuya Yoshimoto Kazutoshi Murata Ken Ando Nobuteru Kubo Noriyuki Okonogi Yosuke Takakusagi Akiko Adachi Mototaro Iwanaga Keisuke Tsuchida Tomoaki Tamaki Shin-ei Noda Yuka Hirota Atsushi Shibata 4 Tatsuya Ohno 5 Takashi Tokino 3 Takahiro Oike and Nakano Department of Radiation Oncology, Gunma University Graduate School Medicine, Gunma, Japan Radiotherapy, Dr. Cipto...
Osteoradionecrosis (ORN) affects the patient's quality of life by making eating and maintaining oral hygiene painful. This study aimed to analyze carbon ion radiotherapy (C-ion RT)-induced ORN mandible.A retrospective 199 patients with head neck tumors treated C-ion RT was performed from 2010 2019. Only 11 located in oropharynx floor mouth were analyzed. consisted 57.6 Gy or 64.0 (relative biological effectiveness) 16 fractions. The mandible analyzed for magnetic resonance imaging (MRI)...
Interstitial lung disease (ILD) is a risk factor both for the development and treatment failure of cancer. In this retrospective study, we analyzed outcome carbon-ion radiotherapy (CIRT) in 124 patients with clinical stage I non-small cell cancer (NSCLC), whom 26 (21%) had radiological signs pre-existing ILD. ILD was diagnosed retrospectively by pulmonologist based on critical review CT-scans. Ninety-eight were assigned to non-ILD group (21.0%) group. There significant differences...
Background/Aim: Bone and soft-tissue sarcomas of the head neck have very poor prognoses. This prospective study aimed to investigate efficacy safety carbon-ion radiotherapy (C-ion RT) for bone sarcoma neck. Patients Methods: The present was a clinical that included 10 consecutive patients diagnosed with who were treated C-ion RT between 2012 2018 at our institution. C-Ion consisted 70.4 Gy (relative biological effectiveness) in 16 fractions. Results: 3-year local control, overall survival,...
A Compton camera is a device for imaging radio-source distribution without using mechanical collimator. Ordered-subset expectation-maximization (OS-EM) widely used to reconstruct images. However, the OS-EM algorithm tends over-concentrate and amplify noise in reconstructed image. It is, thus, necessary optimize number of iterations develop high-quality images, but this has not yet been achieved. In paper, we apply median filter an introduce root prior (MRP-EM) overcome problem. MRP-EM,...