A5041937478- Radiomics and Machine Learning in Medical Imaging
- Chemical Synthesis and Analysis
- Medical Imaging and Pathology Studies
- Radiopharmaceutical Chemistry and Applications
- Peptidase Inhibition and Analysis
- MRI in cancer diagnosis
- Cancer, Hypoxia, and Metabolism
- Neuroscience and Neuropharmacology Research
- Nanoplatforms for cancer theranostics
- Ubiquitin and proteasome pathways
- Cancer Immunotherapy and Biomarkers
- Supramolecular Self-Assembly in Materials
- Renal cell carcinoma treatment
- Advanced Sensor and Energy Harvesting Materials
- Receptor Mechanisms and Signaling
- Conducting polymers and applications
- Pharmacological Receptor Mechanisms and Effects
- Advanced Battery Materials and Technologies
- Medical Imaging Techniques and Applications
- Antimicrobial Peptides and Activities
- Supercapacitor Materials and Fabrication
- Endoplasmic Reticulum Stress and Disease
- Advanced biosensing and bioanalysis techniques
- Cannabis and Cannabinoid Research
- Advancements in Battery Materials
National Institutes for Quantum Science and Technology
2018-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2022-2025
Xinjiang University
2024-2025
Brigham and Women's Hospital
2021-2024
Harvard University
2021-2024
Chinese Academy of Sciences
2012-2022
Guangdong Pharmaceutical University
2022
Beijing Institute of Nanoenergy and Nanosystems
2018-2022
Xi'an High Tech University
2022
Central South University
2021-2022
The use of photothermal agents (PTAs) in cancer therapy (PTT) has shown promising results clinical studies. rapid degradation PTAs may address safety concerns but usually limits the stability required for efficacious treatment. Conversely, with high degrade slowly. solutions that balance between and are rare. Here, we report inherent Cu2+-capturing ability black phosphorus (BP) can accelerate BP, while also enhancing stability. incorporation Cu2+ into BP@Cu nanostructures further enables...
Since the successful exfoliation of graphene from graphite in 2004, and oxide (GO) have been considered most promising two-dimensional (2D) nanomaterials with distinguished physical chemical characteristics attracted great attention many different fields. Graphene is well-known for its distinct physiochemical properties shows only minimal cytotoxicity compared to carbon nanotubes. Until now, limited efforts invested utilizing GO gene therapy pancreatic cancer treatments. In this study, we...
Abstract Conductive, stretchable, environmentally‐friendly, and strain‐sensitive elastomers are attracting immense research interest because of their potential applications in various areas, such as human–machine interfaces, healthcare monitoring, soft robots. Herein, a binary networked elastomer is reported based on composite hydrogel polyvinyl alcohol (PVA) polyethyleneimine (PEI), which demonstrated to be ultrastretchable, mechanically robust, biosafe, antibacterial. The mechanical...
As a novel semiconducting material, the inherent, direct, and appreciable band gap endows BP with preferable optical electronic properties other than graphene transition metal dichalcogenides. In addition, bio-related applications equal importance also attract great attention thanks to several inherited advantages of including large drug loading capacity, high PDT efficiency, biocompatibility degradability. However, date there is limited research about biomedical BP. this study, we reported...
Abstract The addition of a precisely positioned chiral center in the tether constrained peptide is reported, yielding two separable diastereomers with significantly different helicity, as supported by circular dichroism (CD) and NMR spectroscopy. Single crystal X‐ray diffraction analysis suggests that absolute configuration in‐tether helical form R , which agreement theoretical simulations. relationship between secondary structure short peptides their biochemical/biophysical properties...
Abstract Atherosclerosis, a chronic disease associated with metabolism, poses significant risk to human well‐being. Currently, existing treatments for atherosclerosis lack sufficient efficiency, while the utilization of surface‐modified nanoparticles holds potential deliver highly effective therapeutic outcomes. These can target and bind specific receptors that are abnormally over‐expressed in atherosclerotic conditions. This paper reviews recent research (2018–present) advances various...
Peptide nanomaterials were assembled by using helical peptides and served as active materials in supercapacitors.
Abstract Various types of energy exist everywhere around us, and these energies can be harvested from multiple sources to power micro-/nanoelectronic system even personal electronic products. In this work, we proposed a hybrid energy-harvesting (HEHS) for potential in vivo applications. The HEHS consisted triboelectric nanogenerator glucose fuel cell simultaneously harvesting biomechanical biochemical simulated body fluid. These two units work individually as single source or an integrated...
Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKI), such as Erlotinib, have demonstrated remarkable efficacy in the treatment of non-small cell lung cancer (NSCLC) patients with mutated EGFR. However, EGFR-TKIs wild-type (wt) EGFR tumours has been shown to be marginal. Methods that can sensitize Erlotinib NSCLC remain rare. Herein, we developed a multifunctional superparamagnetic nanotheranostic agent novel strategy potentiate EGFR-wt NSCLCs. Our results demonstrate...
Programmed cell death receptor 1 (PD-1) and its ligand PD-L1 are particularly interesting immune checkpoint proteins for human cancer treatment. Positron emission tomography (PET) imaging allows the dynamic monitoring of status during tumor progression, thus informing patients' response index. Herein, we report synthesis two linear peptide-based radiotracers, [64Cu]/[68Ga]HKP2201 [64Cu]/[68Ga]HKP2202, validate their utility visualization in preclinical models. The precursor peptide HKP2201...
An easily accessible fluorescent dye, FEB, which has a high fluorescence quantum yield and is suitable for<italic>in vivo</italic>tumour imaging reported.
With the advantages of being lightweight, flexible, and wearable, wire-shaped supercapacitors have received tremendous attention in wearable portable power sources recent years. Considering demands for large-scale applications, it is necessary to explore a facile convenient preparation approach supercapacitors. Herein, we reported simple fabricate electrodes by dipping method, which possessed nitric acid-activated graphite fiber core an activated carbon-coating layer structure. Parallel...
In the original publication, authors' contribution is missing in acknowledgment section. The correct acknowledgement provided this correction. Also, Fig. 4, second (c) after figure (d) should be read as (e). 5 (i), Y-axis label “Current (μA)” “Voltage”.
Abstract Organoids are three‐dimensional cell aggregates with near‐physiologic behaviors and can undergo long‐term expansion in vitro. They amenable to high‐throughput drug screening processes, which renders them a viable preclinical model for development. The procedure of organoid‐based has been extensively employed discover small‐molecule drugs, encompassing the steps generating organoids, examining efficient drugs organoid cultures, data assessment. Compared small molecules, peptides more...