A5059868524- Hippo pathway signaling and YAP/TAZ
- Forensic and Genetic Research
- Molecular Biology Techniques and Applications
- Microtubule and mitosis dynamics
- Nanoplatforms for cancer theranostics
- Ubiquitin and proteasome pathways
- Sperm and Testicular Function
- Immunotherapy and Immune Responses
- Pancreatic and Hepatic Oncology Research
- Cancer-related Molecular Pathways
- Cancer, Hypoxia, and Metabolism
- RNA Interference and Gene Delivery
- Biological Activity of Diterpenoids and Biflavonoids
- Reproductive Biology and Fertility
- Cancer survivorship and care
- Genetic diversity and population structure
- Liver Disease and Transplantation
- Lipid metabolism and biosynthesis
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer-related gene regulation
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Gut microbiota and health
- Muscle Physiology and Disorders
- Extracellular vesicles in disease
- Melanoma and MAPK Pathways
Huaqiao University
2023-2025
Guizhou Normal University
2024
Sichuan University
2009-2024
Research Center for Eco-Environmental Sciences
2023-2024
Chinese Academy of Sciences
2019-2024
University of Chinese Academy of Sciences
2023-2024
State Key Laboratory of Biotherapy
2017-2024
Shenzhen Luohu People's Hospital
2023-2024
West China Hospital of Sichuan University
2024
Xuzhou Medical College
2023
Yes-associated protein (YAP) is an effector of the Hippo tumor suppressor pathway. The functional significance YAP in prostate cancer has remained elusive. In this study, we first show that enhanced expression able to transform immortalized epithelial cells and promote migration invasion both cancerous cells. We found mRNA was upregulated androgen-insensitive (LNCaP-C81 LNCaP-C4-2 cells) compared level androgen-sensitive LNCaP Importantly, ectopic activated androgen receptor signaling...
Abstract The Yes-associated protein, YAP, is a downstream effector of the Hippo pathway cell-cycle control that plays important roles in tumorigenesis. Hippo-mediated phosphorylation mainly at S127, inactivates YAP function. In this study, we define mechanism for positive regulation activity critical its oncogenic Specifically, found phosphorylated vitro and vivo by kinase CDK1 T119, S289, S367 during G2–M phase cell cycle. We also ectopic expression phosphomimetic mutant (YAP3D, harboring...
// Shuping Yang 1,3,* , Lin Zhang 2,3,* Vinee Purohit 3 Surendra K. Shukla Xingcheng Chen Fang Yu 4 Kai Fu 5 Yuanhong Joyce Solheim Pankaj Singh Wei Song 1 and Jixin Dong Department of Oncology, Shandong Provincial Hospital affiliated with University, Jinan, Shandong, P. R. China 2 Radiation Qilu Eppley Institute for Research in Cancer, Fred Pamela Buffett Cancer Center, Omaha, NE, USA Biostatistics, School Public Health, Pathology Microbiology, University Nebraska Medical * These authors...
Understanding the pathways of human exposure to micro(nano)plastics (MNPs) is crucial for assessing their health impacts. Intravenous infusion can induce MNPs direct entry into blood, posing serious risks on health, but remains unclear. Herein, we developed comprehensive analytical methods detect polyvinyl chloride (PVC) down 20 nm, and found about 0.52 μg equal 105-1011 particles PVC-MNPs released from intravenous products (IVIPs) during each 250 mL injection. The amounts IVIPs were...
Breast cancer is the most common female with considerable metastatic potential, explaining need for new candidates that inhibit tumor metastasis. In our study, betulinic acid (BA), a kind of pentacyclic triterpenoid compound derived from birch trees, was evaluated its anti-metastasis activity in vitro and vivo. BA decreased viability three breast cell lines markedly impaired migration invasion. addition, could activation stat3 FAK which resulted reduction matrix metalloproteinases (MMPs),...
Liposomes (LPs) as commonly used mRNA delivery systems remain to be rationally designed and optimized ameliorate the antigen expression of vaccine in dendritic cells (DCs). In this study, we synthesized mannose-cholesterol conjugates (MPn-CHs) by click reaction using different PEG units (PEG100, PEG1000 PEG2000) linker molecules. MPn-CHs were fully characterized subsequently prepare DC-targeting liposomes (MPn-LPs) a thin-film dispersion method. MPn-LPs loaded with (MPn-LPX) finally prepared...
Purpose: P-glycoprotein (P-gp), which is highly expressed in liver cancer cells, one of the obstacles for treatment cancer. In this study, we have prepared and characterized a kind novel ICG& [email protected] 2 (ICG Cur represent indocyanine green curcumin, respectively) nanoplatform, can achieve photothermal-photodynamic therapy inhibit P-gp effectively safely. Methods: work, plenty studies including drug release, acute toxicity, Western blot, real-time PCR, cell viability, therapeutic...
Background Many meta-analyses have reported the associations between red and processed meat consumption cancer outcomes, but few assessed credibility of evidence. In addition, results dose-effect analyses association outcomes were inconsistently in different articles. Here we propose a protocol for an umbrella review (UR) that be designed to assess these explore potential dose-response relationships. Methods We will independently search five electronic databases two registers from inception...
Emerging evidence has linked metabolic dysfunction-associated steatotic liver disease (MASLD) with accelerated cognitive decline and dementia. We aimed to investigate the associations of MASLD volumes total brain tissue subcortical grey matter, white matter microstructures in UK Biobank. This cross-sectional study included 29,195 individuals (aged 45-82 years) from Biobank who undertook a magnetic resonance imaging (MRI) sub-study between 2014 2022. The MRI covers three modalities (T1, T2...
Abstract Background and Aim: To study the low‐molecular‐weight metabolites in blood plasma of patients with progressive disease, gastric cancer, to characterize different stages from chronic superficial gastritis (CSG) atrophic (CAG), intestinal metaplasia (IM), dysplasia (DYS) finally cancer (GC). Methods: We applied gas chromatography time‐of‐flight mass spectrometry (GC/TOF‐MS) determine levels obtained 80 including 19 CSG, 13 CAG, 10 IM, 15 DYS 22 GC (nine preoperation postoperation)....
Abstract Messenger RNA (mRNA) has come into the spotlight due to its potential for addressing a staggering number of diseases, while lack effective and safe carriers in vivo delivery significantly limits clinical application. Herein, lipid‐like nanoparticles (LLNs) containing three new cholesterol derivatives achieve liver targeting mRNA is investigated. The central composite design (CCD) used tailor formulation LLNs through optimization molar ratios these required targeting. optimized...
// Shuping Yang 1 , Xin Li Xinfeng Liu Xiangbin Ding Xiangbo Congfei Jin Sheng Zhang 3 Guangpeng 2 and Hong Guo College of Animal Science Veterinary Medicine, Tianjin Agricultural University, 300384, China The Key Laboratory Mammalian Reproductive Biology Biotechnology the Ministry Education, Inner Mongolia Hohhot 010070, Institute Biotechnology, Cornell Ithaca, NY 14853, U.S.A Correspondence to: Guo, email: guohong64@163.com Li, gpeng@imu.edu.cn Zhang, sz14@cornell.edu Keywords: myostatin,...
A novel hypoxia-specific and mitochondria-targeted theranostic agent,<bold>HMX-1</bold>, was reported with certified anti-cancer efficiency<italic>in vitro</italic>and<italic>in vivo</italic>.