A5067292361- Cancer, Hypoxia, and Metabolism
- Pancreatic and Hepatic Oncology Research
- Epigenetics and DNA Methylation
- Cancer Research and Treatments
- Biochemical and Molecular Research
- Glycosylation and Glycoproteins Research
- RNA modifications and cancer
- Cancer-related Molecular Pathways
- Autophagy in Disease and Therapy
- Metabolism, Diabetes, and Cancer
- Cancer, Lipids, and Metabolism
- Amino Acid Enzymes and Metabolism
- Mitochondrial Function and Pathology
- Immune cells in cancer
- Nanoplatforms for cancer theranostics
- Nutrition and Health in Aging
- Cancer Genomics and Diagnostics
- Diet and metabolism studies
- Metabolomics and Mass Spectrometry Studies
- Pancreatic function and diabetes
- Cancer Cells and Metastasis
- Muscle Physiology and Disorders
- Hedgehog Signaling Pathway Studies
- Histone Deacetylase Inhibitors Research
- Microtubule and mitosis dynamics
University of Oklahoma Health Sciences Center
2022-2025
University of Florida
2024-2025
University of Oklahoma
2023-2025
Mayo Clinic in Florida
2020-2024
WinnMed
2022-2024
University of Nebraska Medical Center
2015-2024
University of Massachusetts Chan Medical School
2024
Oklahoma City University
2024
Nepal Medical College Teaching Hospital
2024
National Institute of Pharmaceutical Education and Research
2023
We investigated the contribution of Sonic hedgehog (SHH) to pancreatic cancer progression.We expressed SHH in a transformed primary ductal-derived epithelial cell line from human pancreas, hTert-HPNE (T-HPNE), and evaluated effects on tumor growth. also directly inhibited activity vivo by administering blocking antibody mice challenged orthotopically with Capan-2 line, which is known express form moderately differentiated tumors nude mice.Our data provide evidence that expression influences...
Aberrant energy metabolism is a hallmark of cancer. To fulfill the increased requirements, tumor cells secrete cytokines/factors inducing muscle and fat degradation in cancer patients, condition known as cachexia. It accounts for nearly 20% all cancer-related deaths. However, mechanistic basis cachexia therapies targeting thus far remain elusive. A ketogenic diet, high-fat low-carbohydrate diet that elevates circulating levels ketone bodies (i.e., acetoacetate, β-hydroxybutyrate, acetone),...
Aberrant glucose metabolism is one of the hallmarks cancer that facilitates cell survival and proliferation. Here, we demonstrate MUC1, a large, type I transmembrane protein overexpressed in several carcinomas including pancreatic adenocarcinoma, modulates to facilitate growth properties cells. MUC1 occupies promoter elements multiple genes directly involved regulates their expression. Furthermore, expression enhances glycolytic activity We also vivo uptake orthotopic implantation models...
Abstract Pancreatic adenocarcinoma is moderately responsive to gemcitabine-based chemotherapy, the most widely used single-agent therapy for pancreatic cancer. Although prognosis in cancer remains grim part due poor response therapy, previous attempts at identifying and targeting resistance mechanisms have not been very successful. By leveraging The Cancer Genome Atlas dataset, we identified lipid metabolism as metabolic pathway that significantly correlated with gemcitabine patients....
Pancreatic ductal adenocarcinoma (PDAC) is a highly metastatic disease with few effective treatments. Here we show that the mitochondrial calcium uniporter (MCU) promotes PDAC cell migration, invasion, metastasis, and metabolic stress resistance by activating Keap1-Nrf2 antioxidant program. The cystine transporter SLC7A11 was identified as druggable target downstream of MCU-Nrf2 axis. Paradoxically, despite increased ability to uptake cystine, MCU-overexpressing demonstrated characteristics...
Abstract The ability of tumour cells to thrive in harsh microenvironments depends on the utilization nutrients available milieu. Here we show that pancreatic cancer-associated fibroblasts (CAFs) regulate cell metabolism through secretion acetate, which can be blocked by silencing ATP citrate lyase (ACLY) CAFs. We further acetyl-CoA synthetase short-chain family member 2 (ACSS2) channels exogenous acetate dynamic cancer epigenome and transcriptome, thereby facilitating survival an acidic...
Abstract MUC4, a high–molecular weight transmembrane glycoprotein, is overexpressed in pancreatic cancer and implicated its pathogenesis. It heterodimeric protein containing large extracellular, heavily glycosylated subunit, MUC4α, growth factor–like MUC4β. In the present study, we have shown interaction of human MUC4 with receptor tyrosine kinase HER2 adenocarcinoma cells by reciprocal coimmunoprecipitation cocapping studies. colocalized at cell surface cytoplasm. Silencing transient or...
Abstract Adenocarcinoma (ADC) and squamous cell carcinoma (SqCC) are the two predominant subtypes of non-small lung cancer (NSCLC) distinct in their histological, molecular clinical presentation. However, metabolic signatures specific to individual NSCLC remain unknown. Here, we perform an integrative analysis human tumour samples, patient-derived xenografts, murine model NSCLC, lines The Cancer Genome Atlas (TCGA) reveal a markedly elevated expression GLUT1 glucose transporter SqCC, which...
Hypoxia has long been implicated in the pathogenesis of fibrotic diseases. Aberrantly activated myofibroblasts are primary pathological driver progression, yet how various microenvironmental influences, such as hypoxia, contribute to their sustained activation and differentiation is poorly understood. As a defining feature hypoxia its impact on cellular metabolism, we sought investigate hypoxia-induced metabolic reprogramming affects myofibroblast test preclinical efficacy targeting...
Pancreatic cancer is a solid tumour that often fatal. Hence, there an urgent need to identify new drug targets for this disease. Highly proliferating cells have increased demand nutrients and, therefore, up-regulate selective amino acid transporters. Here, we investigated which transporters are up-regulated in pancreatic and whether any of these has potential as target fatal disease.The expression was analysed using publicly available microarray datasets, the findings with transporter...
// Shuping Yang 1,3,* , Lin Zhang 2,3,* Vinee Purohit 3 Surendra K. Shukla Xingcheng Chen Fang Yu 4 Kai Fu 5 Yuanhong Joyce Solheim Pankaj Singh Wei Song 1 and Jixin Dong Department of Oncology, Shandong Provincial Hospital affiliated with University, Jinan, Shandong, P. R. China 2 Radiation Qilu Eppley Institute for Research in Cancer, Fred Pamela Buffett Cancer Center, Omaha, NE, USA Biostatistics, School Public Health, Pathology Microbiology, University Nebraska Medical * These authors...