Rescuing cells from stress damage emerges a potential therapeutic strategy to combat myocardial infarction. Protocatechuic aldehyde (PCA) is major phenolic acid in Chinese herb Danshen (Salvia miltiorrhiza root). This study investigated whether PCA regulated nuclear pyruvate kinase isoform M2 (PKM2) function protect cardiomyocytes. In rats subjected isoprenaline, attenuated heart injury and protected cardiomyocytes apoptosis. Through DARTS CETSA assays, we identified that bound promoted PKM2...

Background Many meta-analyses have reported the associations between red and processed meat consumption cancer outcomes, but few assessed credibility of evidence. In addition, results dose-effect analyses association outcomes were inconsistently in different articles. Here we propose a protocol for an umbrella review (UR) that be designed to assess these explore potential dose-response relationships. Methods We will independently search five electronic databases two registers from inception...

Indigo naturalis (IN) is a traditional Chinese medicine concocted from medicinal plants such as Baphicacanthus cusia (Nees) Bremek. IN has multifaceted pharmacological activities. Recent research highlights the remarkable efficacy of in treating ulcerative colitis (UC). We developed new processing technology without use lime. Correspondingly, content active ingredients relatively increased Naturalis prepared using novel method (NIN). In this study, protective effects NIN on UC was verified...

Psoriasis is an immune disease caused by rapid and incomplete differentiation of skin basal cells. Natural products such as indirubin have historically served excellent sources for the treatments psoriasis. However, poor solubility bioavailability due to its plane rigid crystal structure, which limits efficacy. Herein, improve efficacy indirubin, a hydrogel-based microemulsion drug delivery system was developed transdermal delivery. The mean droplet size optimized 84.37 nm, with...

Pathological cardiac hypertrophy is an important risk factor for cardiovascular disease. However, drug therapies that can reverse the maladaptive process and restore heart function are limited. Ganoderma lucidum polysaccharides (GLPs) one of main active components G. ( ), they have various pharmacological effects. GLPs been used as Chinese medicine prescriptions clinical treatment. In this study, was induced by transverse aortic constriction (TAC) in mice. We found ameliorate Ang II-induced...

Ischemic preconditioning (IPC) is a potential intervention known to protect the heart against ischemia/reperfusion injury, but its role in no-reflow phenomenon that follows reperfusion unclear. Dihydrotanshinone I (DT) natural compound and this study illustrates cardiac ischemic injury from aspect of IPC. Pretreatment with DT induced modest ROS production protected cardiomyocytes oxygen glucose deprivation (OGD), protection was prevented by scavenger. In addition, administration isoprenaline...

Introduction: C-phycocyanin (C-PC), a photosynthetic protein obtained from Spirulina , is regarded highly promising commercially available biochemical. Numerous in vitro and vivo studies have provided evidence of C-PC’s ability to mitigate the inflammatory response, alleviate oxidative stress, facilitate wound healing. However, despite existing knowledge regarding protective mechanism against cellular apoptosis induced by ultraviolet B (UVB) radiation, further experiments are needed explore...

Abstract Traditional Chinese Medicine (TCM) has been developed for thousands of years and formed an integrated theoretical system based on a large amount clinical practice. However, essential ingredients in TCM herbs have not fully identified, their precise mechanisms targets are elucidated. In this study, new strategy combining comprehensive two-dimensional K562/cell membrane chromatographic silico target identification was established to characterize active components from Indigo naturalis...

We proposed a novel method to separate static and dynamic speckles based on spatial frequency domain filtering. First, the raw speckle image sequence is processed frame by through 2D Fourier transform, low-pass high-pass filtering in domain, inverse transform. Then, we can obtain low- high-frequency sequences domain. Second, averaged both time After above processing, mean intensities of components Finally, calculated time-averaged modulation depth map 2-D blood flow distribution. Both...

The rapid development of modern medicine has put forward new requirements for wound infection healing methods in clinical treatment. Despite the great achievements made research and various types dressings recent years, yet there is still a challenge multifunctional effective Herein, nanofibrous membrane was prepared by encapsulating NIR-adsorbed CuS (FSC/CuS) nanoparticles, polyvinylpyrrolidone (PVP) polyvinyl butyral (PVB) with electrospun fish scale collagen. During evaluation healing,...

Myocardial fibrosis is a pivotal pathophysiological step of various cardiovascular diseases, which eventually leads to heart failure and death. Cardiac fibroblasts activation subsequently differentiate into myofibroblasts are in myocardial fibrosis. Phosphoglycerate mutase 1 (PGAM1) directly interacts with α-smooth muscle actin (ACTA2) participate regulation. Allosteric inhibitor PGAM1 could attenuates through break the interaction ACTA2. In this study, we aimed screen identify novel ligand...

Carrier-free self-assembly has gradually shifted the focus of research on natural products, which effectively improve bioavailability and drug-loading rate. However, in spite existing studies, development self-assembled phytochemicals that possess pharmacological effects still scope for further exploration enhancement. Herein, a nano-delivery system was fabricated through direct Rhein Matrine identified as Rhein-Matrine nanoparticles (RM NPs). The morphology RM NPs characterized by TEM....

Gentiana Genus, a herb mainly distributed in Asia and Europe, has been used to treat the damp heat disease of liver for over 2000 years China. Previous studies have shown significant differences compositional contents wild Genus samples from different geographical origins. Therefore, traceable geographic locations are essential ensure practical medicinal value. Over last few years, developments chemometrics facilitated analysis composition herbs via spectroscopy. Notably, FT-IR spectroscopy...

Gentian is a traditional Chinese herb with heat-clearing, damp-drying, inflammation-alleviating and digestion-promoting effects, which widely used in clinical practice. However, there are many species of gentian. According to the pharmacopoeia, Gentiana manshurica Kitag, scabra Bge, triflora Pall Gentianarigescens Franch included. Therefore, accurately identifying gentian important use. In recent years, advantages low cost, convenience, fast analysis high sensitivity, infrared spectroscopy...

Target identification is a crucial process for advancing natural products and drug leads development, which often the most challenging time-consuming step. However, putative biological targets of obtained from traditional prediction studies are also informatively redundant. Thus, how to precisely identify target still one major challenges. Given shortcomings current methodologies, herein, novel in silico docking DARTS strategy was proposed. Concretely, possible molecular weight detected by...

We propose a laser speckle contrast imaging method based on uniting spatiotemporal Fourier transform. First, the raw images are entirely transformed to frequency domain with three-dimensional (3D) fast Second, dynamic and static components extracted by applying 3D low-pass high-pass filtering in inverse Third, we calculate time-averaged modulation depth average of both map two-dimensional blood flow distribution. The experiments demonstrate that proposed could effectively improve...

<title>Abstract</title> <bold>Background: </bold>Pancreatic cancer (PC) patients’ overall survival rate (OS) is associated with multiple factors. The prognosis generally poor, and the extremely low. Although there have been numerous prognostic studies on clinical or genomic characteristics of pancreatic patients, currently no research combining features patients obtained from SEER database tumor TCGA GTEx to explore factors PC patients. <bold>Method: </bold>We 2697 Surveillance,...