A5100342092- Ferroptosis and cancer prognosis
- Autophagy in Disease and Therapy
- Cancer-related molecular mechanisms research
- Cardiac Ischemia and Reperfusion
- Prostate Cancer Treatment and Research
- Autoimmune Bullous Skin Diseases
- Epigenetics and DNA Methylation
- RNA modifications and cancer
- Liver Disease Diagnosis and Treatment
- Vitamin D Research Studies
- Endoplasmic Reticulum Stress and Disease
- Metabolomics and Mass Spectrometry Studies
- Mitochondrial Function and Pathology
- Chemotherapy-induced organ toxicity mitigation
- Urticaria and Related Conditions
- Atherosclerosis and Cardiovascular Diseases
- Cancer, Stress, Anesthesia, and Immune Response
- Peptidase Inhibition and Analysis
- MicroRNA in disease regulation
- Flavonoids in Medical Research
- Sepsis Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- Acute Kidney Injury Research
- Tannin, Tannase and Anticancer Activities
- Traditional Chinese Medicine Analysis
Huaqiao University
2025
Second Affiliated Hospital of Xi'an Jiaotong University
2014-2024
Shandong University of Traditional Chinese Medicine
2019-2024
Harbin Medical University
2021-2024
First Affiliated Hospital of Harbin Medical University
2021-2024
Fujian Medical University
2023-2024
Zhengzhou Central Hospital
2024
University of California, Los Angeles
2024
Capital University
2024
Capital Medical University
2024
Abstract Cancer metabolism is rewired to support cell survival in response intrinsic and environmental stressors. Identification of strategies target these adaptions an area active research. We previously described a cytosolic aspartate aminotransaminase (GOT1)-driven pathway pancreatic cancer used maintain redox balance. Here, we sought identify metabolic dependencies following GOT1 inhibition exploit this feature provide additional insight into regulation metabolism. Using pharmacological...
Vascular damage of hypertension has been the focus treatment, and endothelial progenitor cells (EPCs) play an important role in repair vascular damage. Functional decreased number EPCs are observed peripheral circulation hypertensive patients, but its mechanism is not yet elucidated. Here, we show that patients significantly lower than normal population, cell function decreases with a higher proportion at later stages. A decrease autophagy responsible for senescence induced by AngII....
This study focused on circulating plasma protein profiles to identify mediators of hypertension-driven myocardial remodeling and heart failure.
Recent insights suggest that remnant cholesterol (RC) plays a role in cellular senescence, yet its specific contribution to frailty remains indeterminate. Through the integration of observational and mendelian randomization (MR) studies, this research explores impact elevated serum RC levels on susceptibility.A dual-method approach, combining an study with MR study, was employed investigate connection between frailty. The included 11,838 participants from National Health Nutrition...
Curcumin has numerous anti-carcinogenic properties, but low bioavailability prevents its use in chemotherapeutic applications. One strategy for circumventing this problem been the creation of synthetic analogues. We tested efficacy an analogue known as GO-Y030 human breast and pancreatic cancer cells. compared impact curcumin on cell line MDA-MB-231 lines, PANC-1, HPAC BXPC-3. Both compounds reduced viability induced apoptosis, was substantially more potent. also demonstrated that capable...
Abstract Background Prostate cancer (PCa) is the second leading cause of cancer-related mortality among men worldwide, and its incidence has risen substantially in recent years. Therefore, there an urgent need to identify novel biomarkers precise therapeutic targets for managing PCa progression recurrence. Methods We investigated clinical significance NCAPG2 by exploring public datasets our tissue microarray. Receiver operating characteristic (ROC) curve survival analyses were performed...
The 180-kDa transmembrane hemidesmosomal protein (BPAG2) has been identified as an important autoantigen in bullous pemphigoid (BP). Using the NC16A domain antigenic target, a highly sensitive and specific enzyme-linked immunosorbent assay (ELISA) for detection of autoantibodies to BP180 was developed.To investigate correlation clinical severity ELISA indices BP.Antibody titers sera from 20 patients were measured using BP180NC16a-ELISA, analysis with disease activity performed. Serum...
Macroautophagy and cell death both contribute to innate immunity, but little is known about how these processes integrate. Drosophila larval salivary glands require autophagy for developmentally programmed death, immune signaling factors increase in dying cells. Here, we show that the nuclear factor κB (NF-κB) Relish, a component of deficiency (Imd) pathway, required gland degradation. Surprisingly, classic Imd pathway components, only Relish PGRP receptors were involved Significantly,...
To analyze diabetes mellitus (DM) mortality and years of life lost (YLL) in different subgroups at the national regional levels China from 2005 to 2020.We estimated YLL DM its subcategories for 31 provinces during 2005-2020 using multisource data National Mortality Surveillance System (NMSS).The age standardized rate (ASMR) increased 12.18 per 100,000 13.62 2020, which was an increase 11.86%. The ASMR type 2 (T2DM) much higher than that 1 (T1DM). T1DM remained stable, but T2DM increased,...
Immunomodulation by mesenchymal stem cells (MSCs) is potentially important for maintaining peripheral tolerance. Preeclampsia may be due to maternal immune rejection of the genetically foreign fetus. This study aimed investigate biological function human umbilical cord-derived (HU-MSCs) treatment angiotensin receptor agonistic autoantibody (AT1-AA)-induced hypertension during pregnancy. HU-MSCs were isolated, cultured, and labeled in vitro. AT1-AA administered pregnant rats. Green...
Indigo naturalis (IN) is a traditional Chinese medicine concocted from medicinal plants such as Baphicacanthus cusia (Nees) Bremek. IN has multifaceted pharmacological activities. Recent research highlights the remarkable efficacy of in treating ulcerative colitis (UC). We developed new processing technology without use lime. Correspondingly, content active ingredients relatively increased Naturalis prepared using novel method (NIN). In this study, protective effects NIN on UC was verified...
Background/Objectives: Indigo naturalis (IN) is a traditional Chinese medicine concocted from medicinal plants such as Baphicacanthus cusia (Nees) Bremek. IN has multifaceted pharmacological activities. Recent research highlights the remarkable efficacy of in treating ulcerative colitis (UC). This study investigates Naturalis prepared using novel method (NIN) ameliorating UC. Methods: We have developed new processing technology without use lime. Correspondingly, content active ingredients...