A5034698517- Advancements in Battery Materials
- Supercapacitor Materials and Fabrication
- Drug Solubulity and Delivery Systems
- RNA Interference and Gene Delivery
- Advanced Battery Materials and Technologies
- Nanoparticle-Based Drug Delivery
- Mesoporous Materials and Catalysis
- Advanced Battery Technologies Research
- SARS-CoV-2 and COVID-19 Research
- Lung Cancer Diagnosis and Treatment
- Immunotherapy and Immune Responses
- Crystallization and Solubility Studies
- Advanced biosensing and bioanalysis techniques
- Extraction and Separation Processes
- Diamond and Carbon-based Materials Research
- Advanced battery technologies research
- Drug Transport and Resistance Mechanisms
- Advanced Drug Delivery Systems
- RNA and protein synthesis mechanisms
- Advancements in Transdermal Drug Delivery
- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- Advanced Photocatalysis Techniques
- Supramolecular Self-Assembly in Materials
- Hydrogels: synthesis, properties, applications
Inner Mongolia University
2017-2025
Baotou Research Institute of Rare Earths
2023-2024
State Key Laboratory of Biotherapy
2021-2023
Sichuan University
2021-2023
West China Hospital of Sichuan University
2022-2023
Second Affiliated Hospital of Xi'an Jiaotong University
2016-2023
Shenyang Pharmaceutical University
2017-2021
Yangtze Optical Electronic (China)
2020-2021
Northeastern University
2018-2020
Yangtze River Pharmaceutical Group (China)
2020
Binary transition metal oxides have been attracting extensive attention as promising anode materials for lithium-ion batteries, due to their high theoretical specific capacity, superior rate performance and good cycling stability. Here, loaf-like ZnMn2O4 nanorods with diameters of 80–150 nm lengths several micrometers are successfully synthesized by annealing MnOOH Zn(OH)2 powders at 700 °C 2 h. The electrochemical properties the an material investigated in terms reversible lithium ion...
Because of the low cost and operating potential, Mn3O4 is highly noticeable among transition metal oxides as an anode material for Li-ion batteries. Here, mesoporous nanotubes with a high surface area 42.18 m2 g−1 average pore size 3.72 nm were synthesized first time through hydrogen reduction β-MnO2 under H2/Ar atmosphere at 280 °C 3 h. Electrochemical results demonstrate that reversible capacity 641 mA h (much higher than theoretical graphite, ∼372 g−1) after 100 cycles current density 500...
Abstract Branched MnOOH nanorods with diameters in the range of 50–150 nm and lengths up to tens micrometers were prepared by using potassium permanganate (KMnO 4 ) PEG 400 (PEG=polyethylene glycol) as starting materials through a simple hydrothermal process at 160 °C. After annealing 300 °C under N 2 atmosphere for 5 h, became gradually dehydrated transformed into mesoporous Mn 3 O slight size‐shrinking. The as‐obtained had an average surface area 32.88 m g −1 mean pore size 3.7 nm. Through...
Abstract SARS‐CoV‐2 variants are now still challenging all the approved vaccines, including mRNA vaccines. There is an urgent need to develop new generation vaccines with more powerful efficacy and better safety against variants. In this study, a set of ionizable lipids named 4N4T constructed applied form novel lipid nanoparticles called 4N4T‐LNPs. Leading 4N4T‐LNPs exhibit much higher translation efficiency than SM‐102‐LNPs. To test effectiveness delivery system, DS encoding full‐length S...
It is urgent to develop more effective mRNA vaccines against the emerging severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants owing immune escape. Here, we constructed a novel delivery system [IC8/Mn lipid nanoparticles (IC8/Mn LNPs)]with high immunogenicity, via introducing stimulator of interferon genes (STING) agonist [manganese (Mn)] based on newly synthesized ionizable (IC8). was found that Mn can not only promote maturation antigen-presenting cells activating STING...
Linear control of moisture permeability and anti-adhesion bacteria in a broad temperature region are realized by cross-linking thermoresponsive microgels onto cotton fabrics. The copolymerized monomers di(ethylene glycol) methyl ether methacrylate (MEO2MA), (ethylene (OEGMA300), ethylene glycol (EGMA) with molar ratio 10:10:1. Transition temperatures PMEO2MA POEGMA300 25 60 °C, respectively. Due to the compression already collapsed still swollen POEGMA300, present linear shrinkage (20-70...
To investigate the chest CT imaging characteristics and clinical manifestations of patients with COVID-19 pneumonia. This study included 150 pneumonia diagnosed from January 10 to February 12, 2020 analyze their characteristics. The period between symptom onset initial examination ranged 1 8 days. There were 83 cases (55.33%) involving both lungs, 67 (44.67%) a single lung (left 25 right 42 cases). 49 (32.67%) intrapulmonary lesion, 33 (22.00%) multiple lesions, 68 (44.00%) diffused...
The extraordinary advantages associated with mRNA vaccines, including their high efficiency, relatively low severity of side effects, and ease manufacture, have enabled them to be a promising immunotherapy approach against various infectious diseases cancers. Nevertheless, most delivery carriers many disadvantages, such as toxicity, poor biocompatibility, efficiency in vivo, which hindered the widespread use vaccines. To further characterize solve these problems develop new type safe...
Sheep are an important livestock species whose gastrointestinal tract is essential for overall health. Feed contaminants such as bacterial toxins and mycotoxins severely damage the sheep intestine, yet mechanisms remain mostly elusive partially due to lack of physiologically relevant in vitro models. Here, we investigated molecular underlying deoxynivalenol (DON)-induced toxicity by developing intestinal organoids from isolated crypts Hu sheep. The had a central lumen monolayer epithelium,...
5-Fluorouracil (5-FU) is a widely used chemotherapeutic agent whose incorporation into nucleic acid plays an essential role in its therapeutic efficacy. 5-FU induces severe reproductive toxicity, which has been shown to be reversible. However, the underlying mechanisms have not fully elucidated. Since single-strand-selective monofunctional uracil-DNA glycosylase 1 (Smug1) key enzyme excision of 5-FU, we investigated potential reversible toxicity by integrating knockdown, overexpression and...
The aim of this study was to investigate the effect amorphous solid dispersions (ASDs) on dissolution rate and oral bioavailability Quercetin (Que). First, we prepared Que ASDs with various excipients using hot-melt extrusion find best option. X-ray diffraction (XRD), infrared spectroscopy (IR), Raman were used examine formation Que. Wetting process studied by contact angle solution process. abilities HPMC inhibit crystallization improve membrane permeability demonstrated fluorescence...
Abstract Messenger RNA (mRNA) has come into the spotlight due to its potential for addressing a staggering number of diseases, while lack effective and safe carriers in vivo delivery significantly limits clinical application. Herein, lipid‐like nanoparticles (LLNs) containing three new cholesterol derivatives achieve liver targeting mRNA is investigated. The central composite design (CCD) used tailor formulation LLNs through optimization molar ratios these required targeting. optimized...